Visceral inputs to neurons in the anterior hypothalamus including those that project to the periaqueductal gray: a functional anatomical and electrophysiological study

Snowball, R.K; Semenenko, F. M.; Lumb, Bridget M.

doi:10.1016/s0306-4522(00)00203-7

Cited by 36 publications

(23 citation statements)

References 49 publications

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“…A striking feature of these recent data is that, when compared with results of our earlier study (19), neurons driven by pinch, or by slow rates of heating, of the same peripheral locus (in this case the hindpaw) had very similar distributions throughout the rostral hypothalamus. However, they differed markedly with respect to their projection targets in the PAG; neurons activated by slow rates of skin heating projected predominantly to the ventrolateral sector, and those driven by pinch stimuli projected to the dorsolateral/lateral sector.…”

Section: Hypothalamic-to-midbrain Pathways That Distinguish Between Esupporting

confidence: 58%

“…With respect to the peripheral inputs to the proposed sympathoinhibitory hypothalamic-midbrain axis, initial studies (19) indicated that visceroresponsive neurons in the hypothalamus project to the ventrolateral PAG rather than to its lateral or dorsolateral sector. In contrast, fewer anterior hypothalamic neurons that are activated by noxious somatic stimuli project to the PAG, and those that do project almost exclusively to its dorsolateral/lateral sector (16).…”

Section: Hypothalamic-to-midbrain Pathways That Distinguish Between Ementioning

confidence: 99%

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Hypothalamic and Midbrain Circuitry That Distinguishes Between Escapable and Inescapable Pain

Lumb

2004

Physiology

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Section: Hypothalamic-to-midbrain Pathways That Distinguish Between Esupporting

confidence: 58%

Section: Hypothalamic-to-midbrain Pathways That Distinguish Between Ementioning

confidence: 99%

Hypothalamic and Midbrain Circuitry That Distinguishes Between Escapable and Inescapable Pain

Lumb

2004

Physiology

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“…Following noxious visceral stimulation and retrograde tracer injections in the periaqueductal gray's ventrolateral division, labeled neurons also exhibiting Fos immunoreactivity were identified in the LHAsfa region (Snowball et al, 2000). Projections from the LHAsfa to the dorsal and superior central nuclei of the raphé were reported with retrograde tracer methods (Behzadi et al, 1990;Peyron et al, 1998) and electrical stimulation of the cuneiform nucleus increases c-fos mRNA levels in the region of the LHAsfa (Lam et al, 1997).…”

Section: Projections From Lhasfa and Adjacent Regionsmentioning

confidence: 98%

Projections from the subfornical region of the lateral hypothalamic area

et al. 2005

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The L-shaped anterior zone of the lateral hypothalamic area's subfornical region (LHAsfa) is delineated by a pontine nucleus incertus input. Functional evidence suggests that the subfornical region and nucleus incertus modulate foraging and defensive behaviors, although subfornical region connections are poorly understood. A high-resolution Phaseolus vulgaris-leucoagglutinin (PHAL) structural analysis is presented here of the LHAsfa neuron population's overall axonal projection pattern. The strongest LHAsfa targets are in the interbrain and cerebral hemisphere. The former include inputs to anterior hypothalamic nucleus, dorsomedial part of the ventromedial nucleus, and ventral region of the dorsal premammillary nucleus (defensive behavior control system components), and to lateral habenula and dorsal region of the dorsal premammillary nucleus (foraging behavior control system components). The latter include massive inputs to lateral and medial septal nuclei (septo-hippocampal system components), and inputs to bed nuclei of the stria terminalis posterior division related to the defensive behavior system, intercalated amygdalar nucleus (projecting to central amygdalar nucleus), and posterior part of the basomedial amygdalar nucleus. LHAsfa vertical and horizontal limb basic projection patterns are similar, although each preferentially innervates certain terminal fields. Lateral hypothalamic area regions immediately medial, lateral, and caudal to the LHAsfa each generate quite distinct projection patterns. Combined with previous evidence that major sources of LHAsfa neural inputs include the parabrachial nucleus (nociceptive information), defensive and foraging behavior system components, and the septo-hippocampal system, the present results suggest that the LHAsfa helps match adaptive behavioral responses (either defensive or foraging) to current internal motivational status and external environmental conditions.

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“…The hypothalamus is a central area where many peripheral signals and neural pathways that relate to autonomic functions and motivated behaviors converge [1,2] . The lateral hypothalamic area (LHA) is closely associated with the initiation and regulation of feeding [3][4][5][6][7][8] , and it is well known that neurons in the LHA can sense the blood glucose concentration [9,10] .…”

Section: Introductionmentioning

confidence: 99%

Neurons in the Rat Lateral Hypothalamic Area Integrate Information from the Gastric Vagal Nerves and the Cerebellar Interpositus Nucleus

et al. 2005

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Previous investigations have demonstrated that the neuronal activity in the lateral hypothalamic area (LHA) is respectively modulated by afferent inputs from the gastric vagal nerves innervating the upper gastrointestinal tract, as well as the cerebellar interpositus nucleus (IN). The aim of this study was to examine whether the gastric vagal and cerebellar IN inputs converge onto single LHA neurons in rats, especially those sensitive to glycemia. Of the 114 LHA neurons recorded, 60 (52.6%) and 51 (44.7%) responded to gastric vagal and cerebellar IN stimulation, respectively. Of the 60 LHA neurons responsive to gastric vagal stimulation, 30 also responded to the cerebellar IN stimulus, indicating a convergence of gastric vagal and cerebellar inputs onto single hypothalamic cells. When the gastric vagal nerves and cerebellar IN were stimulated simultaneously, a summation of the responses was observed in all 6 neurons tested. Moreover, of 24 neurons that responded to both the gastric vagal and cerebellar IN stimuli, 15 (62.5%) were identified as glycemia-sensitive. These results demonstrate that the visceral information transmitted by the gastric vagal nerves and the somatic information forwarded by the cerebellar IN converge onto single LHA neurons, especially those sensitive to glycemia. The findings also suggest that integration of somatic-visceral responses related to short-term feeding regulation may take place in the LHA.

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Visceral inputs to neurons in the anterior hypothalamus including those that project to the periaqueductal gray: a functional anatomical and electrophysiological study

Cited by 36 publications

References 49 publications

Hypothalamic and Midbrain Circuitry That Distinguishes Between Escapable and Inescapable Pain

Hypothalamic and Midbrain Circuitry That Distinguishes Between Escapable and Inescapable Pain

Projections from the subfornical region of the lateral hypothalamic area

Neurons in the Rat Lateral Hypothalamic Area Integrate Information from the Gastric Vagal Nerves and the Cerebellar Interpositus Nucleus

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