Visceral fat reference values derived from healthy European men and women aged 20-30 years using GE Healthcare dual-energy x-ray absorptiometry

Miazgowski, Tomasz; Kucharski, Robert; Sołtysiak, Marta; Taszarek, Aleksandra; Miazgowski, Bartosz; Widecka, Krystyna

doi:10.1371/journal.pone.0180614

Cited by 44 publications

(71 citation statements)

References 24 publications

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“…27,28 More recently, different cutoff scores of VAF were established for men (≥599 cm 3 ) and women (≥399 cm 3 ) as a predictor for systolic blood pressure ≥130 mmHg in healthy young European population using DEXA method. 29 In our study, VAF volume values differ from those reported in Japanese and European populations. In the available literature, we did not find previously standardized values of VAF in the world or Mexican population apart from those reported in the European and Japanese population.…”

Section: Discussioncontrasting

confidence: 91%

<p>The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Proinflammatory Cytokines in Subjects with Normal Weight, Overweight and Obesity</p>

García-Sánchez

Gámez-Nava

Cruz

et al. 2020

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Purpose: The increase of visceral abdominal fat (VAF) and oxidative stress (OS) are independent predictors for cardiovascular risk. This study aimed to determine the association of VAF with proinflammatory cytokines, oxidants, antioxidants, and oxidative damage to DNA in subjects with normal weight, overweight, and obesity. Patients and Methods: A cross-sectional study that included 21 men and 71 women who attended for a medical check-up was conducted. Dual-energy X-ray absorptiometry (DXA) was used to measure the VAF volume. ELISA and colorimetric techniques were used for chemical analysis.Results: Low activity of superoxide dismutase (SOD) was found in overweight and obese subjects compared to the normal weight group (p=0.005). In contrast, the activity of glutathione peroxidase (GPx) was higher in the overweight and obesity groups compared to the normal weight subjects (p=0.017). The total antioxidant capacity (TAC) was also increased in the overweight group compared to the normal weight group (p=0.04). According to the volume of VAF, the levels of tumor necrosis factor alfa and interleukin 6 showed no differences between subjects with normal and high VAF. Subjects with high VAF show higher levels of 8-isoprostans compared to normal VAF group (p=0.039). Less concentration of 8-oxoguanine-DNA-N-glycosylase-1 (hOGG1) was found in the high VAF group (p=0.032) compared to the normal VAF subjects. VAF was positively correlated with lipoperoxides (LPO) (r=0.27, p<0.05) and 8-isoprostanes (r=0.25, p<0.05). We also found correlations between oxidative stress markers and anthropometric ratios for intra-abdominal fat. The waist-hip ratio was positively correlated with LPO (r=0.30, p<0.05) and TAC (r=0.24, p<0.05). Conclusion: These findings suggest that the predominantly oxidative damage associated with VAF in overweight or obesity is lipoperoxidation and oxidative DNA damage. Alterations in endogenous antioxidant defenses may not be linked to the amount of VAF.

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Section: Discussioncontrasting

confidence: 91%

<p>The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Proinflammatory Cytokines in Subjects with Normal Weight, Overweight and Obesity</p>

García-Sánchez

Gámez-Nava

Cruz

et al. 2020

DMSO

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“…Similar or even higher rates were found among young white participants in the CARDIA Study (32%), Jackson Heart Study (73%), and African‐PREDICT Study (34%) . A novel finding of our study is that VF, known to be strongly associated with a range of metabolic abnormalities even in healthy individuals, is also suggested here to have had an impact on the magnitude of fall in nocturnal blood pressure. VF (expressed as mass percentage), after adjusting for confounders, was found associated with an absence of physiological nocturnal fall in SBP.…”

Section: Discussionsupporting

confidence: 80%

“…Here, we used this method for the first time in a population of young adults with hypertension. Using our pre‐defined age‐ and gender‐specific VF reference values derived from the healthy population, we found excess VF mass in 52% of males and 47% of females. DXA‐VF was a relatively small fat depot, which constituted only 1.5% of patient weight and 3.1% of TBF.…”

Section: Discussionmentioning

confidence: 99%

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Visceral fat, cardiometabolic risk factors, and nocturnal blood pressure fall in young adults with primary hypertension

Miazgowski

Taszarek

Miazgowski

2019

J of Clinical Hypertension

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The aims of this study were to assess associations of body fat levels and distribution with metabolic profiles and 24-hour blood pressure in young adults with primary hypertension. Visceral fat (VF) was estimated using dual-energy X-ray absorptiometry.VF was highly significantly associated with a high frequency of overweight/obesity, impaired fasting glucose, increased levels of triglycerides and LDL-cholesterol, and lowered level of HDL-cholesterol. The value of systolic blood pressure (SBP) nocturnal fall was similar between patients receiving RAAS inhibitors, beta-blockers, and calcium channel blockers. In multiple regression, the VF/weight ratio after adjusting for age, gender, total fat, and chronotherapeutic drug delivery was associated with the percentage SBP nocturnal fall (β = −.3108; 95% CI: −0.5923; −0.0980; P = .013).In males, excess VF increased the odds by 2.3 times for non-dipping blood pressure.Our results suggest that in young adult hypertensives, the VF/weight ratio might be associated with non-dipping blood pressure. How to cite this article: Miazgowski T, Taszarek A, Miazgowski B. Visceral fat, cardiometabolic risk factors, and nocturnal blood pressure fall in young adults with primary hypertension.

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“…Visceral adipose tissue assessed with different techniques has emerged as a potential marker to evaluate cardio metabolic risk 4,14,[17][18][19][20] . It has been shown that DXA is an adequate tool to assess this parameter 5,14,17,21 . The study by Kaul et al 5 reported that VAT evaluated by DXA had a moderate correlation with AC and weak correlation with BMI and WHR.…”

Section: Discussionmentioning

confidence: 99%

Correlation of body composition parameters using different methods among Brazilian obese adults

Máximo¹,

Melo²,

Porto³

et al. 2019

Rev. bras. cineantropom. desempenho hum.

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Data comparing anthropometric measurements, bioelectrical impedance analysis (BIA) and dual-energy X-ray absortiometry (DXA) parameters are somehow limited and conflicting. The objective of this study was to correlate anthropometric, BIA and DXA parameters among obese Brazilian adults with focus on the comparison with visceral adipose tissue (VAT) obtained from DXA and in the value of antropometric measurements. Fifty voluntary participants were enrolled. The Spearman correlation test was used to assess the correlation of VAT with anthropometric measurements, BIA and other DXA parameters. The intra-class correlation coefficient (ICC) was used to evaluate concordance between lean mass (LM), fat mass (FM), %body fat (%BF) and %upper body fat (%UBF) obtained from BIA and DXA. Most were female (80%) and had an average body index mass (BMI) of 39.0 (± 6.4) kg/m2. The only anthropometric measurements showing a strong correlation with VAT were abdominal circumference (AC) and waist-to-height ratio (WHtR), but just in females. There was a very good correlation for LM [ICC = 0.951 (CI = 0.913 - 0.972)], FM [ICC = 0.987 (CI = 0.977 – 0.993)], %BF [ICC = 0.961 (CI = 0.931-0.978)], and %UBF [ICC = 0.873 (CI = 0.776 – 0.928)], between data collected through BIA and DXA. Among the anthropometric measurements assessed, only AC and WHtR seems to estimate patients with abdominal fat distribution and higher VAT in females. DXA and BIA proved similar for the evaluation of LM, FM, %BF and %UBF, although DXA has the advantage of estimating VAT.

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Visceral fat reference values derived from healthy European men and women aged 20-30 years using GE Healthcare dual-energy x-ray absorptiometry

Cited by 44 publications

References 24 publications

<p>The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Proinflammatory Cytokines in Subjects with Normal Weight, Overweight and Obesity</p>

<p>The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Proinflammatory Cytokines in Subjects with Normal Weight, Overweight and Obesity</p>

Visceral fat, cardiometabolic risk factors, and nocturnal blood pressure fall in young adults with primary hypertension

Correlation of body composition parameters using different methods among Brazilian obese adults

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