Visceral Fat Is Increased in Individuals With Crohn’s Disease: A Comparative Analysis With Healthy Controls

Magro, Daniéla Oliveira; Barreto, Maria Rita Lazzarini; Cazzo, Everton; Camargo, Michel Gardere; Kotze, Paulo Gustavo; Coy, Cláudio Saddy Rodrigues

doi:10.1590/s0004-2803.201800000-25

Cited by 27 publications

(26 citation statements)

References 17 publications

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“…More recently, these investigations have utilized improving imaging and body composition measurement technologies to concentrate specifically on the role of lean tissue and adipose tissue, especially visceral fat, in CD. These have included magnetic resonance imaging (MRI) computed tomography (CT) and, as used in our study, bioimpedance 31 or DEXA 32 . As with our results, most studies determine levels of sarcopenia or relatively low lean tissue indices, combined with elevated adiposity in patients with CD, sometimes correlating with low skeletal mass 33 .…”

Section: Discussionmentioning

confidence: 99%

Adults with Crohn’s disease exhibit elevated gynoid fat and reduced android fat irrespective of disease relapse or remission

Dowling

Jakeman

Norton

et al. 2021

Sci Rep

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Crohn’s disease (CD) is a debilitating inflammatory bowel condition of unknown aetiology that is growing in prevalence globally. Large-scale studies have determined associations between female obesity or low body mass index (BMI) with risk of CD at all ages or 8– < 40 years, respectively. For males, low BMI entering adult life is associated with increased incidence of CD or ulcerative colitis up to 40 years later. Body composition analysis has shown that combinations of lean tissue loss and high visceral fat predict poor CD outcomes. Here, we assessed dietary intake, physical activity and whole or regional body composition of patients with CD relapse or remission. This anthropometric approach found people with CD, irrespective of relapse or remission, differed from a large representative healthy population sample in exhibiting elevated gynoid fat and reduced android fat. CD is associated with mesenteric adipose tissue, or “creeping fat”, that envelops affected intestine exclusive of other tissue; that fat is localised to the android region of the body. In this context, CD mesenteric adiposity represents a stark juxtaposition of organ-specific and regional adiposity. Although our study population was relatively small, we suggest tentatively that there is a rationale to refer to Crohn’s disease as a fatty intestine condition, akin to fatty liver conditions. We suggest that our data provide early insight into a subject that potentially warrants further investigation across a larger patient cohort.

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Section: Discussionmentioning

confidence: 99%

Adults with Crohn’s disease exhibit elevated gynoid fat and reduced android fat irrespective of disease relapse or remission

Dowling

Jakeman

Norton

et al. 2021

Sci Rep

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“…Independently of the general fat mass accumulation, VAT depot has been highlighted as a major risk factor for developing several metabolic, cardiovascular, autoimmune, neurodegenerative, and oncological diseases, as well as an increased risk for early mortality (Van Gaal et al, 2006 ; Cereda et al, 2007 ; Fontes-Carvalho et al, 2014 ; Yu et al, 2015 ; Brown et al, 2017 , 2018 ; Dan Lantsman et al, 2018 ; Kuritzkes et al, 2018 ; Magro et al, 2018 ). The Authors reported a significant relationship between the identified anthropometric tools assessing total and regional adiposity and several health issues, including glucose dysregulation, insulin resistance, metabolic syndrome, cardiometabolic dysregulation, type 2 diabetes, hypertension, cardiovascular diseases, cancer, as well as a higher risk of early cardiovascular and all-cause mortality (Piqueras et al, 2021 ).…”

Section: Health Issues Associated With Obesity Relationship To the Anthropometric Assessment Toolsmentioning

confidence: 99%

“…Yet, in order to manage a disease, we need first to diagnose it. Obesity diagnosis requires to have available easy to use and accurate tools to measure total and regional body fat storage, in particular visceral adiposity, major risk factor of developing obesity related comorbidities (Nicklas et al, 2006 ; Van Gaal et al, 2006 ; Cereda et al, 2007 ; Anan et al, 2010 ; Fontes-Carvalho et al, 2014 ; Yu et al, 2015 ; Brown et al, 2017 , 2018 ; Han et al, 2017 ; Dan Lantsman et al, 2018 ; Kuritzkes et al, 2018 ; Magro et al, 2018 ; Tian et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Commentary: Anthropometric Indicators as a Tool for Diagnosis of Obesity and Other Health Risk Factors: A Literature Review

Samouda

2021

Front. Psychol.

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“…Other conditions linking obesity and CD include: changes in food-intake behavior, increased consumption of industrialized food and animal fat/protein, decreased dietary fiber intake as well as reduction in physical activity [38]. Treatments used for IBD, in particular corticosteroids and anti-TNF-α therapies, have been implicated in weight-gain [39].…”

Section: And Obesitymentioning

confidence: 99%

Bariatric Surgery and Crohn’s Disease

Raziel¹,

Aminov²,

Sakran³

et al. 2019

J Surg Res

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Obesity is a chronic condition significantly associated with health disorders, including type-II diabetes, cardiovascular diseases and inflammation. Its prevalence has been on the rise for the last few decades, contributing to the World Health Organization's statement touting obesity as the pandemic of the millennium. In parallel, its incidence in patients with inflammatory bowel disease (IBD) is rising, with the prevalence of obesity among patients with IBD is similar to that of the general population ~20%-30%. The main common pathophysiological pathways which might link obesity to IBD include: disproportional accumulation of visceral fat, impaired release of adipokines, chronic inflammation, and disturbances in the gut microbiome. Large retrospective studies have shown that obesity is associated with an increased risk of Crohn's Disease (CD), a chronic, progressive, destructive condition whose incidence has been increasing as well (3-20 cases per 100,000). Bariatric surgery is a wellaccepted, effective and safe option for significant and durable weight loss in individuals with morbidly obesity.Even though obesity is associated with higher rates of surgical complexities and postoperative complications (possibly further exacerbated in patients with IBD), data from case studies and multiple data analyses have demonstrated that bariatric surgery in patients with both morbid obesity and CD is safe and effective. Bariatric surgery infers marked improvement in weight-associated comorbidities, massive weight loss, as well as better quality of life, in this special patient population.

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Visceral Fat Is Increased in Individuals With Crohn’s Disease: A Comparative Analysis With Healthy Controls

Abstract: -Background -It is known that obesity is associated with a chronic inflammatory state, but few studies have evaluated visceral fat (VF) content and its role in individuals with Crohn's disease (CD

Cited by 27 publications

References 17 publications

Adults with Crohn’s disease exhibit elevated gynoid fat and reduced android fat irrespective of disease relapse or remission

Adults with Crohn’s disease exhibit elevated gynoid fat and reduced android fat irrespective of disease relapse or remission

Commentary: Anthropometric Indicators as a Tool for Diagnosis of Obesity and Other Health Risk Factors: A Literature Review

Bariatric Surgery and Crohn’s Disease

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