Visceral and body adiposity are negatively associated with vitamin A nutritional status independently of Body Mass Index and recommended intake of vitamin A in Brazilian Women

Ribamar, Amanda; Cruz, Sabrina; Bento, Cleonice Alves de Melo; Ramalho, Andréa

doi:10.1016/j.jnutbio.2022.109120

Cited by 4 publications

(3 citation statements)

References 52 publications

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“…A large proportion of the women (72.8%) however were either overweight or obese. Previous research has found associations between VAD and greater body adiposity 33,34 .…”

Section: Discussionmentioning

confidence: 93%

Assessment of vitamin A levels in breast milk and serum of lactating mothers in Southeast Nigeria

Ezeama,

Okunna,

Afonne

2023

Nor. Afr. J. Food Nutr. Res.

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Background: Vitamin A (VA) is an essential micronutrient critical to human health, infants rely on their mother’s breast milk for sufficient supply. This makes the maternal diet a crucial source of VA for infant growth and development. Aims: This study aimed to assess maternal VA status by assessing serum and breast milk retinol concentrations as well as dietary intake in nursing mothers. Subjects and Methods: A clinic-based cross-sectional study, conducted in Awka, south-east Nigeria, was used to assess 127 lactating women at one to 24 months post-partum. Blood and breast milk samples were obtained from each participant in a fasted state while dietary intake was assessed via an interviewer-administered semi-structured food frequency questionnaire. Retinol concentration was analyzed by spectrophotometry. Descriptive statistics were used to summarize the data while Spearman rank correlation analysis was used to determine associations between breast milk and serum retinol concentrations and study variables. Results: The mean retinol concentration in the serum of the women was a borderline value of 0.75 ± 0.64 µmol/L while the mean retinol concentration in breast milk was 0.99 ± 0.71 µmol/L. Further, the mean milk fat content was 56.18 ± 32.32 g/L while the mean milk retinol to fat ratio was 0.027 ± 0.044 µmol/g. Maternal diet consisted of a preference for provitamin A foods with low bioavailability. The mean retinol concentration in breast milk increased with time post-partum. There was no statistically significant relationship found between the frequency of consumption of most foods and the concentration of retinol in breast milk. Conclusion: The evidence of VA deficiency highlights the need for screening and nutrition education of breastfeeding mothers during ante- and post-natal visits. Keywords: Human milk, serum, vitamin A, maternal diet.

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“…A large proportion of the women (72.8%) however were either overweight or obese. Previous research has found associations between VAD and greater body adiposity 33,34 .…”

Section: Discussionmentioning

confidence: 93%

Assessment of vitamin A levels in breast milk and serum of lactating mothers in Southeast Nigeria

Ezeama,

Okunna,

Afonne

2023

Nor. Afr. J. Food Nutr. Res.

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“…Additionally, a deficiency of this vitamin can activate additional metabolic pathways associated with increased body adiposity. The way body fat was distributed, especially high visceral adiposity, showed an association with compromised nutritional status regardless of the recommended dietary intake [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin A Deficiency and Its Association with Visceral Adiposity in Women

et al. 2023

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Body adiposity is associated with increased metabolic risk, and evidence indicates that vitamin A is important in regulating body fat. The aim of this study was to evaluate serum concentrations of vitamin A and its association with body adiposity in women with the recommended intake of vitamin A. A cross-sectional study was designed with 200 women divided into four groups according to Body Mass Index (BMI): normal weight (NW), overweight (OW), class I obesity (OI), and class 2 obesity (OII). The cut-off points to assess inadequate participants were retinol < 1.05 µmol/L and β-carotene < 40 µg/dL. Body adiposity was assessed through different parameters and indexes, including waist circumference (WC), waist-to-height ratio (WHtR), hypertriglyceridemic waist (HW), lipid accumulation product (LAP), Visceral Adiposity Index (VAI), and Body Adiposity Index (BAI). It was observed that 55.5% of women had low serum concentrations of β-carotene (34.9 ± 13.8 µmol/L, p < 0.001) and 43.5% had low concentrations of retinol (0.71 ± 0.3 µmol/L, p < 0.001). Women classified as OI and OII had lower mean values of β-carotene (OI—35.9 ± 4.3 µg/dL: OII—32.0 ± 0.9 µg/dL [p < 0.001]). IAV showed significant negative correlation with retinol (r = −0.73, p < 0.001). Vitamin A deficiency is associated with excess body adiposity in women with the recommended intake of vitamin. Greater body adiposity, especially visceral, was correlated with reduced serum concentrations of vitamin A.

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“…Adverse relationship between high visceral and body adiposity and vitamin A nutritional status was observed in adult women [ 108 ]. Furthermore, greater expression of RBP4 mRNA in the visceral and subcutaneous adipose tissue was found in obese compared with non-obese adults [ 30 ].…”

Section: Clinical Perspectivesmentioning

confidence: 99%

Vitamin A: A Key Inhibitor of Adipocyte Differentiation

Malibary

2023

PPAR Research

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Inhibiting adipocyte differentiation, the conversion of preadipocytes to mature functional adipocytes, might represent a new approach to treating obesity and related metabolic disorders. Peroxisome proliferator-activated receptor γ and CCAAT-enhancer-binding protein α are two master coregulators controlling adipogenesis both in culture and in vivo. Many recent studies have confirmed the relationship between retinoic acid (RA) and the conversion of embryonic stem cells into adipocytes; however, these studies have shown that RA potently blocks the differentiation of preadipocytes into mature adipocytes. Nevertheless, the functional role of RA in early tissue development and stem cell differentiation, including in adipose tissue, remains unclear. This study highlights transcription factors that block adipocyte differentiation and maintain preadipocyte status, focusing on those controlled by RA. However, some of these novel adipogenesis inhibitors have not been validated in vivo, and their mechanisms of action require further clarification.

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Visceral and body adiposity are negatively associated with vitamin A nutritional status independently of Body Mass Index and recommended intake of vitamin A in Brazilian Women

Cited by 4 publications

References 52 publications

Assessment of vitamin A levels in breast milk and serum of lactating mothers in Southeast Nigeria

Assessment of vitamin A levels in breast milk and serum of lactating mothers in Southeast Nigeria

Vitamin A Deficiency and Its Association with Visceral Adiposity in Women

Vitamin A: A Key Inhibitor of Adipocyte Differentiation

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