Visceral afferent pathways to the thalamus and olfactory tubercle: behavioral implications

Ruggiero, David A.; Anwar, Sabeen; Kim, Jinah; Glickstein, Sara B.

doi:10.1016/s0006-8993(98)00442-9

Cited by 65 publications

(39 citation statements)

References 65 publications

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“…This result, together with the topographic gradient in the projection to the striatum, suggests a complicated organization within Pf. Although the presence of visceral input to Pf had been suggested by anatomical observations of afferent input from the solitary nucleus in rats (Ruggiero et al, 1998) and from the parabrachial nucleus in rats (Saper and Loewy, 1980;Cornwall and Phillipson, 1988;Krout and Loewy, 2000) and monkeys (Prichard et al, 2000), none of these studies suggested segregation of this input within Pf.…”

Section: Organization Of Sensory Input To Pfmentioning

confidence: 96%

Striatal projections of the vagal‐responsive region of the thalamic parafascicular nucleus in macaque monkeys

Ito

Craig

2007

J of Comparative Neurology

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We recently reported that the thalamic parafascicular nucleus (Pf) in monkeys is strongly activated by vagus nerve afferents. The main forebrain target of Pf is the striatum, but the specific striatal regions receiving visceral input via this pathway are unknown. We examined the projections of this region by injecting anterograde tracers into the vagus evoked potential (VEP) focus in Pf of macaque monkeys. The VEP was strongest lateral and anterior to the habenulointerpeduncular tract, but it was distributed across the entire horizontal extent of the ventral half of Pf. All injections produced labeled terminals in the caudate (Cd), especially the Cd tail and the adjacent ventral posterior Pu. Terminations occurred throughout the Cd head and body but spared the most anterior and dorsolateral parts. Injections in more anterior and lateral portions of Pf produced progressively more terminations in Pu, mainly in the precommissural region and the medial aspect of posterior Pu. Dual injections of different tracers revealed overlapping projections with interdigitated strands of striatal terminations from separate regions of Pf as well as the posteromedial to anterolateral topographic gradient of increasing Pf projections to Pu. An injection in the most anteromedial portion of Pf produced strong labeling in the ventral striatum. Thus, Pf transmits viscerosensory information to the "associative" and "limbic" territories of the striatum. These findings suggest the broad involvement of homeostatic afferent activity in striatal function and perhaps a role for the striatum in autonomic function.

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Section: Organization Of Sensory Input To Pfmentioning

confidence: 96%

Striatal projections of the vagal‐responsive region of the thalamic parafascicular nucleus in macaque monkeys

Ito

Craig

2007

J of Comparative Neurology

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“…Ruggiero et al (1998) described "heretofore unrecognized" direct NTS projections to RE and indicated that visceral activity may be routed through RE to the hippocampus and anterior cingulate and infralimbic cortices. Finally, previous reports have also demonstrated significant projections from the dorsal raphe nucleus (Vertes, 1991;Morin and Meyer-Bernstein, 1999;Goto et al, 2001;Krout et al, 2002), median raphe nucleus (Vertes and Martin, 1988;Vertes et al, 1999;Morin and Meyer-Bernstein, 1999), LDT (Cornwall et al, 1990;Krout et al, 2002), PPN (Erro et al, 1999;Krout et al, 2002), and nucleus incertus (Goto et al, 2001;OluchaBordonau et al, 2003) to RE.…”

Section: Afferent Projections To Re: Comparisons With Previous Studiesmentioning

confidence: 99%

Afferent projections to nucleus reuniens of the thalamus

Mckenna

Vertes

2004

J of Comparative Neurology

224

225

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The nucleus reuniens (RE) is the largest of the midline nuclei of the thalamus and the major source of thalamic afferents to the hippocampus and parahippocampal structures. Nucleus reuniens has recently been shown to exert powerful excitatory actions on CA1 of the hippocampus. Few reports on any species have examined afferent projections to nucleus reuniens. By using the retrograde anatomical tracer Fluorogold, we examined patterns of afferent projections to RE in the rat. We showed that RE receives a diverse and widely distributed set of afferents projections. The main sources of input to nucleus reuniens were from the orbitomedial, insular, ectorhinal, perirhinal, and retrosplenial cortices; CA1/subiculum of hippocampus; claustrum, tania tecta, lateral septum, substantia innominata, and medial and lateral preoptic nuclei of the basal forebrain; medial nucleus of amygdala; paraventricular and lateral geniculate nuclei of the thalamus; zona incerta; anterior, ventromedial, lateral, posterior, supramammillary, and dorsal premammillary nuclei of the hypothalamus; and ventral tegmental area, periaqueductal gray, medial and posterior pretectal nuclei, superior colliculus, precommissural/commissural nuclei, nucleus of the posterior commissure, parabrachial nucleus, laterodorsal and pedunculopontine tegmental nuclei, nucleus incertus, and dorsal and median raphe nuclei of the brainstem. The present findings of widespread projections to RE, mainly from limbic/limbic-associated structures, suggest that nucleus reuniens represents a critical relay in the transfer of limbic information (emotional/cognitive) from RE to its major targets, namely, to the hippocampus and orbitomedial prefrontal cortex. RE appears to be a major link in the two-way exchange of information between the hippocampus and the medial prefrontal cortex.

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“…Among the afferents to the midline nuclei are those arising from the hypothalamus and nucleus tractus solitarius (Krout et al, 2002;Ruggiero et al, 1998), which relay interoceptive information to the PVT and thus allow the PVT to integrate exteroceptive (via the reticular formation) and interoceptive cues. The ability to coordinate afferent activity conveying both exteroceptive and interoceptive information may be of critical importance in drug abuse, and lesions of the PVT block the conditioned locomotor response associated with cocaine administration .…”

Section: Functional Implicationsmentioning

confidence: 99%

Distribution of Dopamine D2-Like Receptors in the Human Thalamus: Autoradiographic and PET Studies

Rieck

Ansari

Whetsell

et al. 2003

Neuropsychopharmacol

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The distribution of dopamine (DA) D 2 -like receptors in the human thalamus was studied using in vitro autoradiographic techniques and in vivo positron emission tomography in normal control subjects. [ 125 I]Epidepride, which binds with high affinity to DA D 2 and D 3 receptors, was used in autoradiographic studies to determine the distribution and density of D 2 -like receptors, and the epidepride analogue [ 18 F]fallypride positron was used for positron emission tomography studies to delineate D 2 -like receptors in vivo. Both approaches revealed a heterogeneous distribution of thalamic D 2/3 receptors, with relatively high densities in the intralaminar and midline thalamic nuclei, including the paraventricular, parataenial, paracentral, centrolateral, and centromedian/parafascicular nuclei. Moderate densities of D 2/3 sites were seen in the mediodorsal and anterior nuclei, while other thalamic nuclei expressed lower levels of D 2 -like receptors. Most thalamic nuclei that express high densities of D 2 -like receptors project to forebrain DA terminal fields, suggesting that both the thalamic neurons expressing D 2 -like receptors and the projection targets of these neurons are regulated by DA. Because the midline/intralaminar nuclei receive prominent projections from both the ascending reticular activating core and the hypothalamus, these thalamic nuclei may integrate activity conveying both interoceptive and exteroceptive information to telencephalic DA systems involved in reward and cognition.

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Visceral afferent pathways to the thalamus and olfactory tubercle: behavioral implications

Cited by 65 publications

References 65 publications

Striatal projections of the vagal‐responsive region of the thalamic parafascicular nucleus in macaque monkeys

Striatal projections of the vagal‐responsive region of the thalamic parafascicular nucleus in macaque monkeys

Afferent projections to nucleus reuniens of the thalamus

Distribution of Dopamine D2-Like Receptors in the Human Thalamus: Autoradiographic and PET Studies

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