Visceral Adiposity and the Risk of Impaired Glucose Tolerance

Hayashi, Tomoshige; Leonetti, Donna L.; McNeely, Marguerite J.; Newell‐Morris, Laura; Kahn, Steven E.

doi:10.2337/diacare.26.3.650

Cited by 198 publications

(151 citation statements)

References 28 publications

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“…Studies carried out in different ethnicities showed that VAT, but not SAT, was strongly associated with the development of diabetes 16,17 and coronary heart disease. 18 Increased VAT was associated with impaired glucose tolerance 19 or insulin resistance. 20 The threshold values of VAT for the metabolic disorders differed among different ethnicities.…”

Section: Discussionmentioning

confidence: 99%

Identification of waist circumference cutoffs for abdominal obesity in the Chinese population: a 7.8-year follow-up study in the Shanghai urban area

Bao

Hou

et al. 2009

Int J Obes

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Aim: To identify the appropriate visceral adipose tissue (VAT) cutoff values for the diagnosis of abdominal obesity in predicting diabetes and the corresponding waist circumference in the Chinese population. Methods: At baseline, 381 volunteers aged 35-75 years were enrolled without diabetes from the Shanghai urban area. Anthropometry and VAT area determined by magnetic resonance imaging were measured. During the average 7.8 years of follow-up, glucose tolerance was monitored. Receiver operating characteristic (ROC) curve analysis was used to define the optimal cutoff points for abdominal obesity. Results: At the end of the study, 290 participants were followed up, in which 63 participants developed diabetes. Using ROC curve analyses in participants with normal glucose regulation, the appropriate VAT cutoff was 90 cm 2 for both genders to predict diabetes development. In logistic regression models, the relative risks (95% confidence intervals) of VAT value over 90 cm 2 were 3.35 (1.10-10.18, P ¼ 0.033) in men and 4.57 (1.73-12.07, P ¼ 0.002) in women after adjusted for age, impaired glucose regulation, hypertension and dyslipidemia. The optimal waist circumference cutoffs were 88 cm for men and 82 cm for women to indicate VAT value over 90 cm 2 in ROC analyses. Conclusion: VAT cutoff of 90 cm 2 is useful for defining visceral obesity in Chinese individuals. The appropriate waist circumference cutoffs for abdominal obesity are 88 cm for men and 82 cm for women in the Chinese population.

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Section: Discussionmentioning

confidence: 99%

Identification of waist circumference cutoffs for abdominal obesity in the Chinese population: a 7.8-year follow-up study in the Shanghai urban area

Bao

Hou

et al. 2009

Int J Obes

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“…Abdominal adiposity per se is a specific and independent risk factor as regards insulin resistance, cardiovascular disease (3)(4)(5), glucose intolerance and type 2 diabetes mellitus (6,7). Moreover, adipose tissue is a source of free fatty acids (FFAs) and adipokines, such as adiponectin and resistin (5).…”

Section: Introductionmentioning

confidence: 99%

Rosiglitazone treatment increases plasma levels of adiponectin and decreases levels of resistin in overweight women with PCOS: a randomized placebo-controlled study

Majuri¹,

Santaniemi²,

Rautio³

et al. 2007

eur j endocrinol

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Objective: Abdominal obesity, insulin resistance and compensatory hyperinsulinaemia play a central role in the pathogenesis of the polycystic ovary syndrome (PCOS). Abdominal adipose tissue is a source of adipokines, such as adiponectin and resistin, both of which may be involved in the development of insulin resistance and chronic inflammation in PCOS. Ghrelin, an important regulatory peptide of food intake, may also play a role in metabolic disturbances related to PCOS.The aim of this study was to examine the effects of 4 months of treatment with the insulin sensitizer rosiglitazone on plasma adiponectin, resistin and ghrelin levels in overweight women with PCOS. Design: A randomised placebo-controlled study. Methods: Thirty overweight/obese women with PCOS (body mass indexO25 kg/m 2 , mean age 29.1G 1.2 (S.E.M.) years) were randomly allocated to either rosiglitazone (Avandia, 4 mg twice a day) or placebo treatment. Plasma levels of adiponectin, resistin and ghrelin and their correlation to serum levels of insulin, C-peptide and steroid hormones, and insulin sensitivity (euglycaemic hyperinsulinaemic clamp) were assessed. Results: Adiponectin and ghrelin levels correlated significantly with most metabolic markers of insulin resistance and with serum levels of DHEA and 17-hydroxyprogesterone. Plasma levels of adiponectin increased from 9.26G0.90 (S.E.M.) to 22.22G3.66 mg/ml (P!0.001) and those of resistin decreased from 12.57G1.63 to 9.21G0.53 ng/ml (PZ0.009) at 4 months of treatment, but plasma ghrelin levels did not change. Conclusions: Rosiglitazone had beneficial effects on serum levels of adiponectin and resistin, suggesting that these adipocytokines may contribute to the improvement in insulin sensitivity observed during the treatment.

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“…Adjustment for BMI, waist circumference, or HOMA-IR (a surrogate for insulin resistance) markedly attenuated these associations. Since adipose tissue is a major source of pro-inflammatory cytokines and greater visceral adiposity in Japanese descendants increases the risk of IGT at low BMI values [25], it is to be expected that abdominal adiposity weakens the association between CRP, IGT, and type 2 diabetes. This could explain why this attenuation effect was stronger on the association between CRP and type 2 diabetes, since newly diagnosed diabetic patients had higher proportion of abdominal obesity in this study.…”

Section: Discussionmentioning

confidence: 99%

Elevated C-Reactive Protein, Abdominal Obesity, and Glucose Tolerance Status in Japanese-Brazilians

Cardoso¹,

Hu²,

Gimeno³

et al. 2007

TOEJ

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Abstract:Although evidences indicate that C-reactive protein (CRP) levels are independent predictors of type 2 diabetes (DM), some studies either did not support this association or examine it extensively throughout the stages of glucose tolerance. In a cross-sectional population-based survey, we investigated the relation between CRP and the risk of newly diagnosed impaired glucose tolerance (IGT), and DM among Japanese-Brazilians (374 men and 464 women). In agegender-adjusted analyses, the risks of IGT and type 2 diabetes were significantly higher in the highest CRP tertile as compared with participants with a normal glucose tolerance status (P for trend = 0.0001 in both conditions). After further adjustments for confounding factors, including waist circumference, only the odds of having IGT in the highest CRP tertile was still significant (odds ratio 1.87 [95% CI 1.04-3.37). Our results suggest that low-grade inflammation increases the risk of IGT in Japanese-Brazilians but that some of the risk is confounded by abdominal adiposity.

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Visceral Adiposity and the Risk of Impaired Glucose Tolerance

Cited by 198 publications

References 28 publications

Identification of waist circumference cutoffs for abdominal obesity in the Chinese population: a 7.8-year follow-up study in the Shanghai urban area

Identification of waist circumference cutoffs for abdominal obesity in the Chinese population: a 7.8-year follow-up study in the Shanghai urban area

Rosiglitazone treatment increases plasma levels of adiponectin and decreases levels of resistin in overweight women with PCOS: a randomized placebo-controlled study

Elevated C-Reactive Protein, Abdominal Obesity, and Glucose Tolerance Status in Japanese-Brazilians

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