Visceral Adiposity and High Intramuscular Fat Deposition Independently Predict Critical Illness in Patients with SARS‐CoV‐2

Yang, Yang; Ding, Lin; Zou, Xianlun; Shen, Yaqi; Hu, Daoyu; Hu, Xuemei; Li, Zhen; Kamel, Ihab R.

doi:10.1002/oby.22971

Cited by 92 publications

(145 citation statements)

References 39 publications

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“…Excessive visceral adiposity may provide additional important information about COVID-19 risk, which is not captured in BMI. Evidence of value from two recent studies, which were not included in our analysis due to our study design and eligibility criteria, suggests that visceral adiposity increases the likelihood of severe COVID-19 [15,65]. Central obesity is defined as a state of excessive VAT accumulation [66].…”

Section: Discussionmentioning

confidence: 99%

Obesity in patients with COVID-19: a systematic review and meta-analysis

et al. 2020

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Background: Obesity is common in patients with coronavirus disease 2019 (COVID-19). The effects of obesity on clinical outcomes of COVID-19 warrant systematical investigation. Objective: This study explores the effects of obesity with the risk of severe disease among patients with COVID-19. Methods: Body mass index (BMI) and degree of visceral adipose tissue (VAT) accumulation were used as indicators for obesity status. Publication databases including preprints were searched up to August 10, 2020. Clinical outcomes of severe COVID-19 included hospitalization, a requirement for treatment in an intensive care unit (ICU), invasive mechanical ventilation (IMV), and mortality. Risks for severe COVID-19 outcomes are presented as odds ratios (OR) and 95% confidence interval (95%CI) for cohort studies with BMI-defined obesity, and standardized mean difference (SMD) and 95%CI for controlled studies with VAT-defined excessive adiposity. Results: A total of 45, 650 participants from 30 studies with BMI-defined obesity and 3 controlled studies with VAT-defined adiposity were included for assessing the risk of severe COVID-19. Univariate analyses showed significantly higher ORs of severe COVID

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Section: Discussionmentioning

confidence: 99%

Obesity in patients with COVID-19: a systematic review and meta-analysis

et al. 2020

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“…379 studies were identified after screening titles and abstracts, and 12 studies with 10,304 cases were included conclusively after full-text review. 6 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 Of those, 8 studies reported OR and 4 reported HR, and 8 studies reported the association between cerebrovascular disease and the fatal outcomes. Seven studies came from China, two from America, two from Korea, and one from UK.…”

Section: Resultsmentioning

confidence: 99%

The Association of Cerebrovascular Disease with Adverse Outcomes in COVID-19 Patients: A Meta-Analysis Based on Adjusted Effect Estimates

Xiao

Liang

et al. 2020

Journal of Stroke and Cerebrovascular Diseases

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Objective The aim of this study was to address the association between cerebrovascular disease and adverse outcomes in coronavirus disease 2019 (COVID-19) patients by using a quantitative meta-analysis based on adjusted effect estimates. Method A systematic search was performed in PubMed, Web of Science, and EMBASE up to August 10th, 2020. The adjusted effect estimates were extracted and pooled to evaluate the risk of the unfavorable outcomes in COVID-19 patients with cerebrovascular disease. Subgroup analysis and meta-regression were also carried out. Results There were 12 studies with 10,304 patients included in our meta-analysis. A significant trend was observed when evaluating the association between cerebrovascular disease and adverse outcomes (pooled effect = 2.05, 95% confidence interval (CI): 1.34–3.16). In addition, the pooled effects showed that patients with a history of cerebrovascular disease had more likelihood to progress fatal outcomes than patients without a history of cerebrovascular disease (pooled effect = 1.78, 95% CI: 1.04–3.07). Conclusion This study for the first time indicated that cerebrovascular disease was an independent risk factor for predicting the adverse outcomes, particularly fatal outcomes, in COVID-19 patients on the basis of adjusted effect estimates. Well-designed studies with larger sample size are needed for further verification.

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“…The use of imaging diagnostics for body composition makes maximal use of existing information and could help to recognize and treat patients at increased risk of wasting with targeted pathways. In fact, some studies have already used CT images to describe the body composition of patients with COVID-19 (49)(50)(51) ,…”

Section: Interrelations Between Prolonged Hospitalization Weight Losmentioning

confidence: 99%

Can COVID-19 be a risk for cachexia for patients during intensive care? Narrative review and nutritional recommendations

et al. 2020

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Although increased weight, and particularly obesity, has been associated with a more severe clinical course of COVID-19 and risk of fatality, the course of the illness can lead to prolonged length of stay. Changes in nutritional status and weight loss during hospitalization are largely reported in some populations, but still not explored in COVID-19 patients. Considering that patients with COVID-19 show an increased inflammatory response, other signs and symptoms, which can lead to weight and muscle loss should be monitored. The aim of this article was to establish possible connections between COVID-19, prolonged hospitalization and muscle wasting, as well as to propose nutritional recommendations for the prevention and treatment of cachexia, through a narrative review. Identification of risk and presence of malnutrition should be an early step in general assessment of all patients, with regard to more at-risk categories including older adults and individuals suffering from chronic and acute disease conditions, as COVID-19. The deterioration of nutritional status, and consequently cachexia, increase the risk of mortality, and need to be treated with attention as other complications. There is, however, little hard evidence of nutritional approaches in assisting COVID-19 treatment or its management including cachexia.

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Visceral Adiposity and High Intramuscular Fat Deposition Independently Predict Critical Illness in Patients with SARS‐CoV‐2

Cited by 92 publications

References 39 publications

Obesity in patients with COVID-19: a systematic review and meta-analysis

Obesity in patients with COVID-19: a systematic review and meta-analysis

The Association of Cerebrovascular Disease with Adverse Outcomes in COVID-19 Patients: A Meta-Analysis Based on Adjusted Effect Estimates

Can COVID-19 be a risk for cachexia for patients during intensive care? Narrative review and nutritional recommendations

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