Visceral adiposity and arterial stiffness: echocardiographic epicardial fat thickness reflects, better than waist circumference, carotid arterial stiffness in a large population of hypertensives

Natale, Francesco; Tedesco, Michele Adolfo; Mocerino, Rosa; Simone, Vincenzo De; Marco, Giovanni Maria Di; Aronne, Luigi; Credendino, Maria; Siniscalchi, Carmine; Calabrò, Paolo; Cotrufo, Maurizio; Calabrò, Raffaele

doi:10.1093/ejechocard/jep002

Cited by 170 publications

(144 citation statements)

References 44 publications

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“…13 Many studies have concluded that EAT is higher in the patients with diabetics, HT and obesity. [6][7][8][21][22][23] DM and HT are closely related with the metabolic syndrome and the two most frequently observed reasons of the increased cardiovascular risk in the general population and the ESRF patients. No study has been recorded yet which addresses uremic factors and its relationship with EAT in the dialysis patients without DM and HT.…”

Section: Discussionmentioning

confidence: 99%

Echocardiographic evaluation of epicardial adipose tissue in non-diabetic, non-hypertensive hemodialysis patients

2013

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Turkey AbstractPurpose: It has been found out that the epicardial adipose tissue (EAT) measured by echocardiography is related with various metabolic parameters. Being accepted as the new cardiovascular risk indicator, there have been few studies on EAT in relation to the patients with end-stage renal failure. In our study, we aim to evaluate EAT and carotid intima media thickness (CIMT) in non-diabetic, non-hypertensive hemodialysis (HD) patients. Methods: Our study recruited 47 non-diabetic, non-hypertensive HD patients (22 males, 25 females, median age 54 (44.3-60.8) years) and an age-gender matched control group consisting 41 healthy subjects (17 males, 24 females, median age 52 (48-56) years). In all patients, EAT was measured by echocardiography and CIMT by ultrasonography; and routine laboratory parameters were studied. Results: In our study, we obtained laboratory findings matching with the profiles of uremic patients among HD patients and CIMT values of HD patients are significantly higher than that of the control group

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Section: Discussionmentioning

confidence: 99%

Echocardiographic evaluation of epicardial adipose tissue in non-diabetic, non-hypertensive hemodialysis patients

2013

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“…In a recent study it was reported that epicardial fat volume (EFV) was the best predictor for angiographic disease severity compared to waist circumference or visceral abdominal fat volume (4). Furthermore, it has been demonstrated that vascular aging and subclinical atherosclerosis, as revealed by carotid stiffness and intimamedia thickness, are related to epicardial fat thickness better than waist circumference in hypertensive patients (5). Even in non-obese patients epicardial fat may be more related to the development of coronary atherosclerosis than the traditional cardiovascular risk factors and abdominal visceral adipose tissue (6).…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of epicardial fat volume: effects of scanning protocol and reproducibility of measurements in non-contrast cardiac CT vs. coronary CT angiography

D’Errico

Salituri

Ciardetti

et al. 2017

Quant. Imaging Med. Surg.

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Background: Several studies have focused on the role of epicardial fat in the pathogenesis of cardiovascular disease (CVD). The main purpose of the study was to evaluate a computerized method for the quantitative analysis of epicardial fat volume (EFV) by non-contrast cardiac CT (NCT) for coronary calcium scan and coronary CT angiography (coronary CTA). Conclusions: Both NCT and coronary CTA can be used with low intra-and inter-observer variability for computer-assisted measurements of EFV. Cardiac CT may allow a fast and reliable computation of EFV in clinical setting.

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“…Adipocytes expand during normal aging, promoting visceral obesity and dysfunctional elevations of circulating AngII (Pacholczyk et al 2013). Chronic increases in AngII production mechanically damage the vascular wall (Zieman et al 2005), resulting in arterial stiffness and blood pressure variability (Thalmann and Meier 2007;Natale et al 2009). Arterial stiffness and elevated body mass are both significant predictors of white matter abnormalities and risk for ischemic stroke in older individuals (Safar et al 2000;Kuo et al 2010;Strazzullo et al 2010;Verstynen et al 2012), suggesting that abnormal activation of the peripheral RAS may influence cerebrovascular mechanisms of age-related white matter degeneration.…”

Section: Introductionmentioning

confidence: 99%

Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults

Salminen

Schofield

Pierce

et al. 2014

AGE

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Vascular aging consists of complex and multifaceted processes that may be influenced by genetic polymorphisms of the renin-angiotensin system. A polymorphism in the angiotensin II type 1 receptor gene (AGTR1/rs5186) has been associated with an increased risk for arterial stiffness, hypertension, and ischemic stroke. Despite these identified relationships, the impact of AGTR1 A1166C on white matter integrity and cognition is less clear in a healthy aging population. The present study utilized indices of neuroimaging and neuropsychological assessment to examine the impact of the A1166C polymorphism on subcortical hyperintensities (SH) and cognition in 49 healthy adults between ages 51-85. Using a dominant statistical model (CC + CA (risk) vs. AA), results revealed significantly larger SH volume for individuals with the C1166 variant (p<0.05, partial eta 2 = 0.117) compared with those with the AA genotype. Post hoc analyses indicated that increased SH volume in C allele carriers could not be explained by vascular factors such as pulse pressure or body mass index. In addition, cognitive performance did not differ significantly between groups and was not significantly associated with SH in this cohort. Results suggest that presence of the C1166 variant may serve as a biomarker of risk for suboptimal brain integrity in otherwise healthy older adults prior to changes in cognition.

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Visceral adiposity and arterial stiffness: echocardiographic epicardial fat thickness reflects, better than waist circumference, carotid arterial stiffness in a large population of hypertensives

Abstract: Our findings indicate that epicardial fat reflects carotid artery stiffness in hypertension-induced organ damage.

Cited by 170 publications

References 44 publications

Echocardiographic evaluation of epicardial adipose tissue in non-diabetic, non-hypertensive hemodialysis patients

Echocardiographic evaluation of epicardial adipose tissue in non-diabetic, non-hypertensive hemodialysis patients

Quantitative analysis of epicardial fat volume: effects of scanning protocol and reproducibility of measurements in non-contrast cardiac CT vs. coronary CT angiography

Impact of the AGTR1 A1166C polymorphism on subcortical hyperintensities and cognition in healthy older adults

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