Visceral adipose tissue is significantly associated with hearing thresholds in adult women

Kim, Tae Su; Park, Sung Won; Kim, Do Yeon; Kim, Eon Bin; Chung, Jong Woo; So, Hong-Seob

doi:10.1111/cen.12184

Cited by 32 publications

(26 citation statements)

References 31 publications

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“…In an animal study, obesity could exacerbate the hearing impairment with elevated hearing thresholds31. In humans, central obesity (i.e., either a higher amount of visceral adipose tissue or a greater WC), was found to be related to an elevated hearing threshold3233. There is also evidence indicating that oxidative stress is a critical factor that links obesity with its associated complications16.…”

Section: Discussionmentioning

confidence: 99%

Secondhand Smoke is Associated with Hearing Threshold Shifts in Obese Adults

Lin

Kao

et al. 2016

Sci Rep

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Hearing loss resulted from multiple intrinsic and extrinsic factors. Secondhand smoke (SHS) and obesity had been reported to be related to hearing loss. This study explored the possible associations of SHS and obesity with the hearing threshold. The relations between SHS and the hearing threshold in subjects from three different body mass index classes were analyzed. Our study included data from 1,961 subjects aged 20–69 years that were obtained from the National Health and Nutrition Examination Survey for the years 1999–2004. After adjusting for potential confounding factors, the subjects with the higher tertiles of serum cotinine levels tended to have higher hearing thresholds than those with the lowest tertile of serum cotinine levels (for both trends, p < 0.05). Notably, the obese subjects with the higher tertiles of serum cotinine levels had significantly higher hearing thresholds for high frequencies and low frequencies than those with the lowest tertile of serum cotinine levels (for both trends, p < 0.05). Our study showed a significant positive association between SHS exposure and hearing thresholds in the adult population, especially in obese individuals. Based on our findings, avoiding exposure to SHS, especially in obese adults, may decrease the risk of hearing loss.

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Section: Discussionmentioning

confidence: 99%

Secondhand Smoke is Associated with Hearing Threshold Shifts in Obese Adults

Lin

Kao

et al. 2016

Sci Rep

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“…Obesity was found to be associated with hearing loss in both humans and animals [ 34 , 35 ]. Moreover, it was proposed that central obesity, as well as an increased waist circumference or content of visceral adipose tissue, was significantly associated with an increased hearing threshold after adjusting for body mass index [ 36 , 37 ]. In the present study, we also observed that an increased waist circumference was significantly associated with an increase high-PTA threshold.…”

Section: Discussionmentioning

confidence: 99%

Components of Metabolic Syndrome as Risk Factors for Hearing Threshold Shifts

et al. 2015

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BackgroundHearing loss was a common, chronically disabling condition in the general population and had been associated with several inflammatory diseases. Metabolic syndrome, which was associated with insulin resistance and visceral obesity, was considered a chronic inflammatory disease. To date, few attempts had been made to establish a direct relationship between hearing loss and metabolic syndrome. The aim of the present study was to investigate the relationship between metabolic syndrome and hearing loss by analyzing the data in the reports of the National Health and Nutrition Examination Survey 1999–2004.MethodsThis study included 2100 participants aged ≤ 65 years who enrolled in the National Health and Nutrition Examination Survey (1999–2004). We examined the relationship between the presence of different features of metabolic syndrome in the participants and their pure-tone air-conduction hearing thresholds, including low-frequency and high-frequency thresholds.ResultsAfter adjusting for potential confounders, such as age, medical conditions, and smoking status, the participants with more components of metabolic syndrome were found to have higher hearing thresholds than those with fewer components of metabolic syndrome (p < 0.05 for a trend). The low-frequency hearing threshold was associated with individual components of metabolic syndrome, such as abdominal obesity, high blood pressure, elevated triglycerides, and a low level of high-density lipoprotein cholesterol (HDL-C) (p < 0.05 for all parameters).ConclusionsThe results indicated that the presence of a greater number of components of metabolic syndrome was significantly associated with the hearing threshold in the US adult population. Among the components of metabolic syndrome, the most apparent association was observed between low HDL and hearing loss.

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“…The β-CG-fed mice exhibited less body weight gain than control mice, despite comparable food intake. Recent epidemiological studies have associated obesity with the severity of hearing loss [ 4 , 5 ]. Diet-induced obesity exacerbates auditory degeneration in mice [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Age-related hearing impairment (ARHI) is common in older populations, with an estimated prevalence of 30–60%; it has a strong influence on quality of life [ 1 – 3 ]. Recently, higher body mass index (BMI) and waist circumference have been associated with the severity of hearing loss [ 4 , 5 ]. Obesity-related disorders including dyslipidemia and type 2 diabetes are also associated with ARHI [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Soybean β-Conglycinin Prevents Age-Related Hearing Impairment

et al. 2015

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Obesity-related complications are associated with the development of age-related hearing impairment. β-Conglycinin (β-CG), one of the main storage proteins in soy, offers multiple health benefits, including anti-obesity and anti-atherosclerotic effects. Here, to elucidate the potential therapeutic application of β-CG, we investigated the effect of β-CG on age-related hearing impairment. Male wild-type mice (age 6 months) were randomly divided into β-CG-fed and control groups. Six months later, the body weight was significantly lower in β-CG-fed mice than in the controls. Consumption of β-CG rescued the hearing impairment observed in control mice. Cochlear blood flow also increased in β-CG-fed mice, as did the expression of eNOS in the stria vascularis (SV), which protects vasculature. β-CG consumption also ameliorated oxidative status as assessed by 4-HNE staining. In the SV, lipofuscin granules of marginal cells and vacuolar degeneration of microvascular pericytes were decreased in β-CG-fed mice, as shown by transmission electron microscopy. β-CG consumption prevented loss of spiral ganglion cells and reduced the frequencies of lipofuscin granules, nuclear invaginations, and myelin vacuolation. Our observations indicate that β-CG ameliorates age-related hearing impairment by preserving cochlear blood flow and suppressing oxidative stress.

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Visceral adipose tissue is significantly associated with hearing thresholds in adult women

Abstract: Our findings show an association between VAT and hearing impairment in women. A reduction in visceral adiposity may help to prevent hearing loss in women.

Cited by 32 publications

References 31 publications

Secondhand Smoke is Associated with Hearing Threshold Shifts in Obese Adults

Secondhand Smoke is Associated with Hearing Threshold Shifts in Obese Adults

Components of Metabolic Syndrome as Risk Factors for Hearing Threshold Shifts

Soybean β-Conglycinin Prevents Age-Related Hearing Impairment

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