Visceral adipose tissue glucose uptake is linked to prognosis in multiple myeloma patients: An exploratory study

Júnior, Ademar Dantas da Cunha; Silveira, Marina Nogueira; Takahashi, Maria Emília Seren; Souza, Elemir Macedo de; Mosci, Camila; Ramos, Celso Darío; Brambilla, Sandra Regina; Pericole, Fernando V; Prado, Carla M.; Mendes, Maria Carolina Santos; Carvalheira, José Barreto Campello

doi:10.1016/j.clnu.2021.02.010

Cited by 11 publications

(6 citation statements)

References 55 publications

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“…IL-2 and TNF- α are cytokines that play a protective role in multiple myeloma [ 18 ]. TNF- α is an important molecule in the autoimmune stage of the body, which has a certain role in tumor killing and inhibiting tumor growth [ 19 ]. IL-2 can induce the production of NK cells and increase the ability to dissolve tumor cells [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Efficacy Evaluation of Inflammatory Mediators in the Treatment of Multiple Myeloma with Daratumumab

Meng

Zhao

Jiang

et al. 2022

Journal of Oncology

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Objective. This study aimed to investigate the regulatory ability and clinical therapeutic effect of daratumumab on inflammatory mediators in patients with multiple myeloma. Method. The Multiple Myeloma Public Genetic Data Array download GSE125361 dataset was collected. The GO analysis and KEGG analysis were performed on the differential genes to elucidate the multiple myeloma cytokine-related gene pathways. Daratumumab is a CD38 monoclonal antibody used to treat multiple myeloma. Patients with newly diagnosed multiple myeloma were treated with monoclonal antibodies containing CD38, and the control group was treated with a regimen without daratumumab. The serum levels of IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ were measured in the two groups before and after treatment and the therapeutic effects of the two groups were compared. Result. The KEGG analysis showed that the Th17 cell differentiation, apoptosis, and cytokine-cytokine receptor interaction pathways were differentially expressed in multiple myeloma. The expression levels of serum IL-2, IL-6, IL-10, and TNF-α in patients in the daratumumab group were lower than those in the control group after chemotherapy. The overall effective rate of patients treated with daratumumab after chemotherapy was higher than that of the control group. Conclusion. Daratumumab can effectively improve the levels of IL-2, IL-6, IL-10, and TNF-α in patients with multiple myeloma and improve the therapeutic effect.

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Section: Discussionmentioning

confidence: 99%

Efficacy Evaluation of Inflammatory Mediators in the Treatment of Multiple Myeloma with Daratumumab

Meng

Zhao

Jiang

et al. 2022

Journal of Oncology

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“…Cachexia is a complex process, and anthropomorphic measures such as body mass index (BMI) and skeletal muscle depletion may not be suitable as prognostic biomarkers for cancer survival [50][51][52]. Although "gold standard" techniques are still not available for precisely measuring cancer cachexia progression in patients with MM, emergent evidence indicates that abnormalities in adipose tissue depots are associated with survival outcomes in MM patients [53][54][55][56]. Specifically, increased visceral adipose tissue (VAT) was identified as a predictive factor of poor treatment response [53], while lower subcutaneous adipose tissue (SAT) was associated with reduced survival [54].…”

Section: Fdg Uptake Of Adipose Tissue and Radiodensitymentioning

confidence: 99%

“…Specifically, increased visceral adipose tissue (VAT) was identified as a predictive factor of poor treatment response [53], while lower subcutaneous adipose tissue (SAT) was associated with reduced survival [54]. SAT radiodensity and increased VAT glucose uptake are associated with unfavorable prognosis in MM patients [55,56]. FDG uptake in VAT is usually measured in a slice at the third lumbar vertebra (L3) level.…”

Section: Fdg Uptake Of Adipose Tissue and Radiodensitymentioning

confidence: 99%

Metabolic Volume Measurements in Multiple Myeloma

et al. 2021

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Multiple myeloma (MM) accounts for 10–15% of all hematologic malignancies, as well as 20% of deaths related to hematologic malignant tumors, predominantly affecting bone and bone marrow. Positron emission tomography/computed tomography with 18F-fluorodeoxyglucose (FDG-PET/CT) is an important method to assess the tumor burden of these patients. It is often challenging to classify the extent of disease involvement in the PET scans for many of these patients because both focal and diffuse bone lesions may coexist, with varying degrees of FDG uptake. Different metrics involving volumetric parameters and texture features have been proposed to objectively assess these images. Here, we review some metabolic parameters that can be extracted from FDG-PET/CT images of MM patients, including technical aspects and predicting MM outcome impact. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) are volumetric parameters known to be independent predictors of MM outcome. However, they have not been adopted in clinical practice due to the lack of measuring standards. CT-based segmentation allows automated, and therefore reproducible, calculation of bone metabolic metrics in patients with MM, such as maximum, mean and standard deviation of the standardized uptake values (SUV) for the entire skeleton. Intensity of bone involvement (IBI) is a new parameter that also takes advantage of this approach with promising results. Other indirect parameters obtained from FDG-PET/CT images, such as visceral adipose tissue glucose uptake and subcutaneous adipose tissue radiodensity, may also be useful to evaluate the prognosis of MM patients. Furthermore, the use and quantification of new radiotracers can address different metabolic aspects of MM and may have important prognostic implications.

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“…Fat distribution more than overall body weight has been a key determinant of the risk for cardiovascular diseases (5) . Previous studies have shown visceral adipose tissue (VAT) was an important obesity-related predictor of cardiovascular risk in 70-year-old men, and by implication, that decreasing VAT may potentially reduce their risk of cardiovascular disease (6) and a higher VAT might be an early biomarker of cancer cachexia in multiple myeloma patients (7) . Body roundness index (BRI) was a new anthropometric index developed to predict both body fat and the percentage of visceral adipose tissue (8) .…”

Section: Introductionmentioning

confidence: 99%

A nonlinear association between body roundness index and all-cause mortality and cardiovascular mortality in general population

Zhou

Liu

Huang

et al. 2022

Public Health Nutr.

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Objective The aim of the study was to investigate the association between BRI and all-cause mortality and cardiovascular mortality in general population. Design A retrospective cohort study. Participants A sample of 47,356 participants from the National Health and Nutrition Examination Surveys (NHANES) 1999–2014 with aged ≥18 years old. Setting The status of cardiovascular mortality and all-cause mortality of participants were followed through 31 December 2015. Multivariate adjusted Cox restricted cubic spline regression models and Kaplan-Meier survival curves were used to evaluate the relationship between BRI and cardiovascular mortality and all-cause mortality. Results Mean age was 47 years and female were 49.9%. During a median follow-up of 92 months, 4715 participants died from any cause, with 985 died of cardiovascular disease. In multivariate adjusted Cox regression, compared with the lowest quartile of BRI, the HRs for all-cause mortality from other quartiles were 0.83 (0.75, 0.92), 0.73 (0.65, 0.81), and 0.80 (0.72, 0.89), respectively (P for trend < 0.05) and the HRs for cardiovascular mortality from other quartiles were 0.79 (0.62, 1.00), 0.78 (0.62, 0.99), and 0.79 (0.62, 1.01), respectively (P for trend > 0.05). In the restricted cubic spline regression models, the relationship was showed U-shaped between BRI and all-cause mortality and cardiovascular mortality. In Kaplan-Meier survival curves, the lowest cumulative survival rate of cardiovascular mortality and all-cause mortality was recorded in the highest BRI quartile. Conclusions The U-shaped association between BRI and all-cause mortality and cardiovascular mortality in a large population-based cohort was observed.

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Visceral adipose tissue glucose uptake is linked to prognosis in multiple myeloma patients: An exploratory study

Cited by 11 publications

References 55 publications

Efficacy Evaluation of Inflammatory Mediators in the Treatment of Multiple Myeloma with Daratumumab

Efficacy Evaluation of Inflammatory Mediators in the Treatment of Multiple Myeloma with Daratumumab

Metabolic Volume Measurements in Multiple Myeloma

A nonlinear association between body roundness index and all-cause mortality and cardiovascular mortality in general population

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