Viruses vs. Superbugs

Häusler, Thomas

doi:10.1007/978-0-230-55228-9

Cited by 50 publications

(26 citation statements)

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“…(ii) This substance has become of special significance in recent times, notably through the work of Walsh,(iii) in that biosynthetic investigations(iv) have enabled the production of analogues displaying useful biological properties through the genetic manipulation of producing organisms. Such efforts could lead to novel anti-infective agents with improved therapeutic properties, thereby alleviating the ongoing “antibiotic crisis.”(v)…”

Section: Introductionmentioning

confidence: 99%

Total Synthesis and Complete Structural Assignment of Thiocillin I

Aulakh

Ciufolini

2011

J. Am. Chem. Soc.

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Section: Introductionmentioning

confidence: 99%

Total Synthesis and Complete Structural Assignment of Thiocillin I

Aulakh

Ciufolini

2011

J. Am. Chem. Soc.

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“…Replication at the site of infection is another advantage of phages. They are safe with no or less side effects [10,11]. If bacteria become resistant to phages then phages do evolve naturally to infect the aforementioned resistant bacteria, hence minimizing the chances of bacterial escape, which scores another advantage of phage over antibiotics [10].…”

Section: Phage Therapymentioning

confidence: 99%

Bacteriophages and their implications on future biotechnology: a review

Haq

Chaudhry

Akhtar

et al. 2012

Virol J

238

189

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Recently it has been recognized that bacteriophages, the natural predators of bacteria can be used efficiently in modern biotechnology. They have been proposed as alternatives to antibiotics for many antibiotic resistant bacterial strains. Phages can be used as biocontrol agents in agriculture and petroleum industry. Moreover phages are used as vehicles for vaccines both DNA and protein, for the detection of pathogenic bacterial strain, as display system for many proteins and antibodies. Bacteriophages are diverse group of viruses which are easily manipulated and therefore they have potential uses in biotechnology, research, and therapeutics. The aim of this review article is to enable the wide range of researchers, scientists, and biotechnologist who are putting phages into practice, to accelerate the progress and development in the field of biotechnology.

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“…Phages are then extensively used and developed mainly in former Soviet Union countries. Several commercial laboratories and companies in the USA, France and Germany developed phase products (Hausler, 2006). The golden age in use of phage was in the 1930s, but with antibiotics discovery, the progress of phage research and use was reduced.…”

Section: Phage Therapymentioning

confidence: 99%

Challenges and future prospects of antibiotic therapy: from peptides to phages utilization

et al. 2014

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Bacterial infections are raising serious concern across the globe. The effectiveness of conventional antibiotics is decreasing due to global emergence of multi-drug-resistant (MDR) bacterial pathogens. This process seems to be primarily caused by an indiscriminate and inappropriate use of antibiotics in non-infected patients and in the food industry. New classes of antibiotics with different actions against MDR pathogens need to be developed urgently. In this context, this review focuses on several ways and future directions to search for the next generation of safe and effective antibiotics compounds including antimicrobial peptides, phage therapy, phytochemicals, metalloantibiotics, lipopolysaccharide, and efflux pump inhibitors to control the infections caused by MDR pathogens.

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Viruses vs. Superbugs

Cited by 50 publications

References 0 publications

Total Synthesis and Complete Structural Assignment of Thiocillin I

Total Synthesis and Complete Structural Assignment of Thiocillin I

Bacteriophages and their implications on future biotechnology: a review

Challenges and future prospects of antibiotic therapy: from peptides to phages utilization

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