Viruses Isolated from Natural Common Colds in the U.S.A

Hamre, Dorothy; Procknow, John J.

doi:10.1136/bmj.2.5264.1382

Cited by 56 publications

(19 citation statements)

References 11 publications

(4 reference statements)

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“…RSV infection in an adult was noted 40 years ago by Beem et al [31]. One year later, in 1961, Hamre and Procknow [32] reported the recovery of RSV isolates from 15 medical students; these isolates accounted for 4% of all isolates collected during a 4-year period [33]. Berglund [37] and, by virus isolation, in 5 adult members in families in Tecumseh, Michigan, who were studied by Monto and Cavallaro [38].…”

Section: Discussionmentioning

confidence: 98%

Respiratory Syncytial Virus Infections in Previously Healthy Working Adults

Hall¹,

Long²,

Schnabel³

2001

CLIN INFECT DIS

225

180

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During 1975-1995, a total of 2960 healthy adults, 18-60 years of age, were prospectively evaluated for respiratory virus infections. Of these subjects, 211 (7%) acquired respiratory syncytial virus (RSV) infection. The infections were symptomatic in 84% of subjects, involved only the upper respiratory tract in 74%, and included lower respiratory tract symptoms in 26%. Overall, 40% of the subjects were febrile. Lower respiratory tract signs developed in 26%. RSV illnesses were more prolonged than non-RSV respiratory illnesses. Compared with influenza, RSV infections were less frequently associated with fever and headache, but were associated significantly more often with nasal congestion, ear and sinus involvement, and productive cough. Absence from work during the acute phase of the illness resulted from 38% of RSV infections and 66% of influenza cases. The mean duration of RSV illness (9.5 days), however, was significantly longer than that of influenza (6.8 days). The occurrence of annual epidemics of RSV, the virus' potential to reinfect all age groups, and the morbidity associated with these reinfections suggest that RSV infections in working adults may result in appreciable costs for medical visits and absence from work.

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Section: Discussionmentioning

confidence: 98%

Respiratory Syncytial Virus Infections in Previously Healthy Working Adults

Hall¹,

Long²,

Schnabel³

2001

CLIN INFECT DIS

225

180

View full text Add to dashboard Cite

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“…Had there been more specimens from general practice, and an even larger number from very mild respiratory infections, the isolation rate would have been nearer 30% (Kendall et al, 1962 ;Hamre andProcknow, 1963 Higgins et al, 1963).…”

Section: Discussionmentioning

confidence: 99%

Viruses Associated with Acute Respiratory Infections

Clarke¹,

Corner²,

Gambier³

et al. 1964

BMJ

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“…In several instances, virus was isolated from subjects with a respiratory illness and yet there was no evidence of an antibody response by any of the three serological techniques. This has been observed in natural and experimental infections with respiratory syncytial virus (Chanock, Kim, Vargosko, Deleva, Johnson, Cumming & Parrott, 1961;Kravetz, Knight, Chanock, Morris, Johnson, Rifkind & Utz, 1961;Hamre & Procknow, 1961) and in natural infections with para-influenza viruses (Chanock, Bell &Parrott, 1961). This stresses the point that a diagnosis of infection may have to be made on the evidence of virus isolation alone without an accompanying homotypic antibody response.…”

Section: Discussionmentioning

confidence: 99%

Para-influenza 2 virus infections in adult volunteers

Taylor‐Robinson¹,

Bynoe²

1963

Epidemiol. Infect.

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Twenty-eight adult volunteers were inoculated intranasally with para influenza 2 virus and eight developed illnesses; twenty-eight volunteers were given flanks' saline and one became ill. The illnesses occurred in volunteers given between 2 × 104 and 2 × 106 TCD 50 of virus. The most prominent symptoms were sore throat, nasal stuffiness and coryza; four of the eight volunteers had sufficient coryza to be regarded as having mild colds. Although only eight volunteers had clinical evidence of infection, twenty-four had laboratory evidence of infection as judged by virus re-isolation or antibody response. Neutralization, haemagglutination-inhibition and complement-fixation tests on paired sera showed that sixteen individuals had a fourfold or greater antibody response by one or more tests including five of the eight volunteers who were ill. Twenty volunteers, including seven who were ill, had reciprocal neutralizing antibody titres of eight or more before inoculation of virus so it seems that the illnesses were due to re infection in the presence of antibody. Evidence is presented which suggests that although illnesses occurred in the presence of antibody they were due to the para influenza 2 virus and not some other agent in the inoculum. The results of these experiments seem to fulifi the third of Koch's postulates for para-influenza 2 virus as a cause of respiratory disease in adults.We wish to thank Dr P. A. J. Tyrreil for his advice during the course of this work and in the preparation of the manuscript. We also thank Dr K. V. Shah (The Johns Hopkins University, Baltimore, U.S.A.) for help in some of the early experiments and Miss B. Ridgwell for valuable technical assistance.

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Viruses Isolated from Natural Common Colds in the U.S.A

Cited by 56 publications

References 11 publications

Respiratory Syncytial Virus Infections in Previously Healthy Working Adults

Respiratory Syncytial Virus Infections in Previously Healthy Working Adults

Viruses Associated with Acute Respiratory Infections

Para-influenza 2 virus infections in adult volunteers

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