Viruses in transplantology

Mucha, Krzysztof; Foroncewicz, Bartosz; Dębska‐Ślizień, Alicja; Durlik, Magdalena; Grenda, Ryszard; Horban, Andrzéj; Fiedor, Piotr; Krajewska, Magdalena; Kwiatkowski, Artur; Lerut, Jan; Małyszko, Jacek; Małyszko, Jolanta; Przybyłowski, Piotr; Zieniewicz, Krzysztof; Ciszek, Michał; Kamińska, Dorota; Kosieradzki, Maciej; Perkowska‐Ptasińska, Agnieszka; Czerniawska, Justyna; Dęborska, D; Kwieciński, R; Kwapisz, Magdalena; Moszczuk, Barbara; Iesari, Samuele; Pączek, L

doi:10.20452/pamw.15012

Cited by 2 publications

(2 citation statements)

References 83 publications

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“…Pending the results of other controlled studies in this area, these methods are being used increasingly, especially in patients with high comorbidity, long duration of dialysis therapy and contraindications to kidney transplantation [8]. Some experts recommended the use of high-volume online HDF in patients whose Age Adjusted Charlson Comorbidity Index (AACCI) is ≥ 8 [9]. Particularly clinical benefits have been demonstrated in patients with hemodynamic instability, poorly controlled blood pressure (BP), polyneuropathy, calcium-phosphate disorders, pruritus or erythropoietin resistance, among others [2,10].…”

Section: Introductionmentioning

confidence: 99%

Intradialytic Tolerance and Recovery Time in Different High-Efficiency Hemodialysis Modalities

Zakrzewska,

Biedunkiewicz,

Komorniczak

et al. 2023

Preprint

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There are several forms of maintenance high-efficiency hemodialysis (HD) including hemodiafiltrations (HDF) in different technic modes and expanded HD using dialyzers with medium cut-off membranes. The aim of the study was to assess the intradialytic tolerance and length of dialysis recovery time (DRT) in these modalities. This is an exploratory, cross-over study in maintenance HD patients with low comorbidity and no clinical indications for the use of high-efficiency HD, who were exposed to five intermittent dialysis in random order: high flux hemodialysis (S-HD), expanded HD (HDx), pre-dilution HDF (PRE-HDF), mix-dilution HDF (MIX-HDF) and post-dilution HDF (POST-HDF). 24 dialysis sessions of each method were included in the analysis. Dialysis parameters including blood flow rate, dialysis fluid flow rate and temperature, and pharmacological treatment were constant. Average total convection volume for post-HDF, pre-HDF and mix-HDF were 25.6 (3.8), 61.5 (7.2) and 47.1 (11.4) l, respectively. During all therapies, patients had similar hydration status monitored using bioimpedance spectroscopy and similar variability over time in systemic blood pressure, cardiac output, and peripheral resistance monitored using impedance cardiography. The lowest frequency of all intradialytic adverse events were observed during HDx. Delayed DRT was the shortest during PRE-HDF. Patients were also more likely to report immediate recovery while receiving PRE-HDF. These differences did not reach statistical significance, however the study results suggest that, intradialytic tolerance and DRT may depend on the dialysis method used. This support the need of taking into account patient preferences and quality of life while individualizing high efficiency therapy in HD patients.

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Section: Introductionmentioning

confidence: 99%

Intradialytic Tolerance and Recovery Time in Different High-Efficiency Hemodialysis Modalities

Zakrzewska,

Biedunkiewicz,

Komorniczak

et al. 2023

Preprint

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“…As the health care system adapts to the COVID 19 pandemic, an understanding of disease progression and prognosis in specific patient cohorts will allow for targeted and personalized care. Transplant recipients are of particular interest, as the chronic use of immunosuppression impairs the ability to fight off viral infection, thus increasing their susceptibility to the SARS-CoV 2 virus [ 1 , 2 ]. Kidney transplant patients commonly present with comorbidities including hypertension, diabetes mellitus, and cardiovascular disease, which have been demonstrated to be risk factors associated with worse SARS-CoV 2 severity and higher mortality [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Renal allograft function in kidney transplant recipients infected with SARS-CoV 2: An academic single center experience

et al. 2021

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Background Kidney transplant recipients are a unique cohort in regard to SARS-CoV 2 susceptibility and clinical course, owing to their immunosuppressed state and propensity for kidney injury. The primary purpose of this study is to ascertain if, in kidney transplant recipients, SARS-CoV 2 infection impacts long term renal allograft function. Methods This retrospective, single-center study reviewed 53 kidney transplant recipients with a positive SARS-CoV-2 PCR at NMH from January 1, 2020 to June 30, 2020. Results Change in eGFR from baseline kidney function prior to infection to 90 days after the first positive SARS-CoV 2 test was +1.76%, -17.5% and -23.16% the mild, moderate and severe disease groups respectively. There was a significant decline in kidney function in the moderate and severe disease cohorts as compared to the mild disease cohort, with respective p values of p = 0.0002 and p = 0.021. Relative to the mild disease cohort, the moderate and severe disease cohorts also demonstrated significantly increased risk of developing AKI (66%, 85%), both with p values of P = 0.0001. Conclusions Clinically severe SARS-CoV 2 infection is associated with greater risk of acute kidney injury and greater decline in renal allograft function at 90 days post infection, compared to mild disease.

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Viruses in transplantology

Cited by 2 publications

References 83 publications

Intradialytic Tolerance and Recovery Time in Different High-Efficiency Hemodialysis Modalities

Intradialytic Tolerance and Recovery Time in Different High-Efficiency Hemodialysis Modalities

Renal allograft function in kidney transplant recipients infected with SARS-CoV 2: An academic single center experience

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