Viruses in pulp and periapical inflammation: a review

Vigueras, Scarlette Hernández; Zúñiga, Manuel Donoso; Jané‐Salas, Enric; Navarrete, Luis Salazar; Segura-Egea, Juan José; Ortega, Eugenio Velasco; López‐López, José

doi:10.1007/s10266-015-0200-y

Cited by 22 publications

(15 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, systemic conditions i.e. poor glycemic control [ 6 ], diabetes [ 7 ] viral diseases [ 8 ] and lowered bone mineral density [ 9 ] seem to predispose to the occurrence of AP. Different epidemiological cross-sectional studies show AP being a widespread condition in many countries, and its prevalence is positively correlated with age (Additional file 1 : Table S1), gender and socioeconomic status of the region.…”

Section: Introductionmentioning

confidence: 99%

Apical periodontitis in southern Estonian population: prevalence and associations with quality of root canal fillings and coronal restorations

et al. 2017

View full text Add to dashboard Cite

BackgroundApical periodontitis (AP) is an inflammatory disease around the apex of a tooth root. Reported prevalence of AP ranges from 27% to 83% while the data about most post-Soviet countries are still missing. Knowing the prevalence of AP within a certain population helps to plan the treatment need and evaluate the success of endodontic interventions. We aimed to collect data about prevalence and determining factors of AP for the first time in Estonia.MethodsThe cross-sectional study included 6552 patients (age 35.5±19.2 years). Radiographic examination was applied to investigate the prevalence of AP and quality of endodontic treatment.ResultsAP was diagnosed in 54.7% of subjects. Endodontically treated teeth were present in 58.2% of subjects. Periapical finding was present in 44.6% of endodontically treated and in 30.8% of untreated teeth.Out of 181,495 teeth, 52.7% were intact. AP was diagnosed in 6.3% of teeth, 6.9% of teeth were endodontically treated.Risk factors for AP included caries (OR = 2.30), male gender (OR = 1.44), too short (OR = 1.76) or too long root canal filling (OR = 2.51), root canal filling of low density (OR = 1.61) while not orthodontic appliance. Lower AP risk was associated with restoration of the tooth – filling (OR = 0.45), crown (OR = 0.34) and bridge (OR = 0.33).ConclusionsAP is highly prevalent in Southern Estonian population. Most cases are associated with root canal-treated teeth. The overall quality of root canal fillings tends to be low, consistent with the mediocre outcome of treatment. Considerable efforts are required to improve the standards of endodontic treatment.Electronic supplementary materialThe online version of this article (10.1186/s12903-017-0429-7) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionmentioning

confidence: 99%

Apical periodontitis in southern Estonian population: prevalence and associations with quality of root canal fillings and coronal restorations

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Bacterial penetration has been reported as an important risk factor of pulp inflammation, necrosis and periapical pathosis [21]. LPS, the main component of the outer membrane of Gram-negative bacteria, plays a key role in bacteria-induced dental pulp inflammation and pulpitis [22].…”

Section: Discussionmentioning

confidence: 99%

The protective effects of saxagliptin against lipopolysaccharide (LPS)-induced inflammation and damage in human dental pulp cells

Guo

Chen

2019

Artificial Cells, Nanomedicine, and Biotechnology

View full text Add to dashboard Cite

Bacteria play a pivotal role in the pathological initiation and progression of pulpitis. Lipopolysaccharide (LPS) is recognized as a major component of the outer wall of Gram-negative bacteria. Saxagliptin, a potent inhibitor of dipeptidyl peptidase-4 (DPP-4), has been licensed for the treatment of type 2 diabetes. In this study, we aimed to evaluate the protective effects of saxagliptin against LPS-induced intracellular insults in human dental pulp cells (HDPCs). We found that DPP-4 is expressed in HDPCs. Interestingly, the expression of DPP-4 was increased in response to LPS treatment. We also found that saxagliptin ameliorated LPS-induced production of ROS and reduction of glutathione (GSH). Additionally, saxagliptin prevented LPS-induced mitochondrial dysfunction by increasing the levels of mitochondrial membrane potential (MMP) and the production of adenosine triphosphate (ATP). Importantly, saxagliptin ameliorated LPS-induced reduction of cell viability and lactate dehydrogenase (LDH) release. Our results indicate that saxagliptin significantly inhibited LPS-induced expression and secretions of tumour necrosis factor alpha (TNF-a), interleukin (IL)-1b and IL-6 in HDPCs. Mechanistically, we found that saxagliptin inhibited the phosphorylation of p38 and the activation of NF-jB. Our findings suggest that saxagliptin might have a potential therapeutic capacity for the treatment of pulpitis through mitigating inflammatory signalling in dental pulp cells.

show abstract

“…Of note, it was reported that periodontal therapy led to decrease in the amount of detectable EBV as well as HSV-1 and CMV in chronic periodontitis patients ( p < 0.05) compared to baseline ( 95 ). Regarding endodontic lesions, a recent review by Hernández-Vigueras and colleagues reported that EBV was identified in a significant number of endodontic diseases ( 96 ). In total, EBV was detected in 41% of clinical samples compared to only 2% for controls.…”

Section: Clinical Manifestations Of Oral Disease Associated Herpesvirmentioning

confidence: 99%

Herpesviruses and MicroRNAs: New Pathogenesis Factors in Oral Infection and Disease?

et al. 2018

View full text Add to dashboard Cite

The oral cavity incessantly encounters a plethora of microorganisms. Effective and efficient oral innate and adaptive immune responses are incumbent to maintain healthy mucosa. A higher prevalence of Human Herpesviruses (HHV), a family of large enveloped DNA viruses, has been reported in multiple oral inflammatory diseases suggesting their involvement in disease progression. However, the viral components contributing to oral disease remain obscure. MicroRNAs (miRNA) are non-protein coding, single stranded ribonucleic acid (RNA) molecules that post-transcriptionally regulate diverse messenger RNAs. Thus, miRNAs can control large repertoire of biological processes. Changes in miRNA expression are associated with various oral infections and diseases. Cellular miRNAs can act as pro- or anti-viral factors and dysregulation of host miRNA expression occurs during herpesviruses infection. This strongly suggest a critical role of cellular miRNAs in host-herpesvirus interaction. Interestingly, HHV also encode multiple miRNAs (called viral miRNAs) that may play key role in host-pathogen interaction by modulating both host biological pathways and controlling viral life cycle. Recent studies from our laboratory have identified viral miRNAs (v-miRs) in diseased oral tissue biopsies and demonstrate their immunomodulatory roles. This review discusses the association of miRNAs (both host and viral) and herpesviruses in the pathogenesis of oral inflammatory diseases.

show abstract

Viruses in pulp and periapical inflammation: a review

Cited by 22 publications

References 50 publications

Apical periodontitis in southern Estonian population: prevalence and associations with quality of root canal fillings and coronal restorations

Apical periodontitis in southern Estonian population: prevalence and associations with quality of root canal fillings and coronal restorations

The protective effects of saxagliptin against lipopolysaccharide (LPS)-induced inflammation and damage in human dental pulp cells

Herpesviruses and MicroRNAs: New Pathogenesis Factors in Oral Infection and Disease?

Contact Info

Product

Resources

About