Viruses and Type 1 Diabetes: From Enteroviruses to the Virome

Isaacs, Sonia R; Foskett, Dylan B; Maxwell, Anna J; Ward, Emily; Faulkner, Clare L; Luo, Jessica Y X; Rawlinson, William D.; Craig, Maria E.; Kim, Ki Wook

doi:10.20944/preprints202106.0574.v1

Cited by 14 publications

(3 citation statements)

References 243 publications

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“…There exists a relationship between enteroviral infection and T1D development as suggested in two meta‐analyses of 24 and 38 case–control studies 10,11 . Furthermore, several experimental data strongly support the involvement of CVB in the pathogenesis of this disease 12–14 …”

Section: Introductionmentioning

confidence: 91%

Combating coxsackievirus B infections

Nekoua

Mercier

Vergez

et al. 2022

Reviews in Medical Virology

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Coxsackieviruses B (CVB) are small, non‐enveloped, single‐stranded RNA viruses belonging to the Enterovirus genus of the Picornaviridae family. They are common worldwide and cause a wide variety of human diseases ranging from those having relatively mild symptoms to severe acute and chronic pathologies such as cardiomyopathy and type 1 diabetes. The development of safe and effective strategies to combat these viruses remains a challenge. The present review outlines current approaches to control CVB infections and associated diseases. Various drugs targeting viral or host proteins involved in viral replication as well as vaccines have been developed and shown potential to prevent or combat CVB infections in vitro and in vivo in animal models. Repurposed drugs and alternative strategies targeting miRNAs or based on plant extracts and probiotics and their derivatives have also shown antiviral effects against CVB. In addition, clinical trials with vaccines and drugs are underway and offer hope for the prevention or treatment of CVB‐induced diseases.

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Section: Introductionmentioning

confidence: 91%

Combating coxsackievirus B infections

Nekoua

Mercier

Vergez

et al. 2022

Reviews in Medical Virology

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“…The Coxsackie B4 virus may also activate T lymphocytes, causing direct damage to β-cells. A viral infection may also cause T cells to produce pro-inflammatory cytokines, increasing the body's inflammatory cell activation and infiltration (19) . An extra advantage is an autoimmune response against beta cells caused by structural similarities between viral protein epitopes and cellular antigens.…”

Section: Detection Of Anti-coxv-b Igg Antibodymentioning

confidence: 99%

ASSOCIATION OF ANTI-COXSACKIE VIRUS-B IgG WITH AUTOANTIBODIES RELATED TO TYPE 1 DIABETES MELLITUS

Hassan¹,

Al-Shuwaikh²,

Al-Auqili³

2022

IraqiJMS

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Background: Coxsackievirus B is a virus may cause type 1 diabetes. There are links between Coxsackievirus B infections and type 1 diabetes. The presence of autoantibodies in pancreatic beta cells has been linked to the development of type 1 diabetes following Coxsackievirus B infection. Objective: To detect autoantibodies in patients with type 1 diabetes. Also, to find if there is an association between pancreatic beta cell autoantibodies and Coxsackievirus-B IgG. Methods: This study was done from January to March 2021, it included two groups of 75 children; their ages ranged from one month to fifteen years. Children with type 1 diabetes were admitted to the diabetic and endocrine glands center in Thi-Qar governorate, whereas children without diabetes (control group) were admitted to Bint Al-Huda Children's Hospital in Nasiriyah/Thi-Qar. Venous blood was taken from each person for estimation of random blood sugar, serum fructosamine, and HbA1c in the laboratory of the diabetic and endocrine glands center. Pancreatic beta cell autoantibodies and anti-Coxsackievirus-B IgG was detected by enzyme-linked immunosorbent assay. The statistical analyses were done using SPSS 25. The study population P-values below 0.05 to be statistically significant. The study was authorized by Al-Nahrain University's Institutional Review Board and parental consent was taken. Results: The patients had significantly greater levels of random blood sugar, fructosamine, and HbA1c than healthy controls. Anti-islet antigen, anti-islet cell, anti-glutamic acid decarboxylase, and anti-Coxsackievirus-B IgG antibody titers were greater in patients than controls. The majority of autoantibodies tested correlated with Coxsackievirus-B IgG antibodies. Conclusion: Anti-Coxsackievirus-B IgG antibody positivity was associated with autoantibodies related to type 1 diabetes mellitus. Keywords: Coxsackievirus B, type 1 diabetes, autoantibodies Citation: Hassan HG, Al-Shuwaikh AM, Al-Auqili RKD. Association of Anti-Coxsackie Virus-B IgG with autoantibodies related to type 1 diabetes mellitus. Iraqi JMS. 2022; 20(1): 132-138. doi: 10.22578/IJMS.20.1.17

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“…Les Entérovirus en sont un autre exemple avec des preuves moléculaires qui s'accumulent concernant leur participation à la survenue d'une auto-immunité ciblant les îlots de Langerhans du pancréas, à l'origine d'un diabète de type 1. Cependant, les génotypes viraux précis responsables n'ont pas encore été identifiés [65].…”

Section: Du Symbiotique Au Pathologique Et Vice-versaunclassified

Ces virus qui nous habitent et qui nous visitent : le virome humain

Ottmann

2022

Med Sci (Paris)

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Les progrès récents des nouvelles techniques de séquençage ont ouvert la voie au décryptage du virome humain qui peut être défini comme l’ensemble de tous les virus présents dans le corps humain. Ces virus sont de différents types : endogènes, procaryotes, archéaux et eucaryotes. Chaque partie du corps humain constitue un microenvironnement différent et possède donc un virome qui lui est propre. Les infections virales peuvent être catégorisées selon l’issue de la phase aiguë. Jusqu’à récemment, seules les infections symptomatiques étaient étudiées. Cette revue résume l’état actuel de nos connaissances et propose une définition du virome humain sous l’angle des principes de l’écologie, en considérant l’être humain comme un écosystème.

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Viruses and Type 1 Diabetes: From Enteroviruses to the Virome

Cited by 14 publications

References 243 publications

Combating coxsackievirus B infections

Combating coxsackievirus B infections

ASSOCIATION OF ANTI-COXSACKIE VIRUS-B IgG WITH AUTOANTIBODIES RELATED TO TYPE 1 DIABETES MELLITUS

Ces virus qui nous habitent et qui nous visitent : le virome humain

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