Viruses and mycoplasma (PPLO) in human leukemia

Dmochowski, L; Taylor, H. G.; Grey, Clifford E.; Dreyer, D. A.; Sykes, J.; Langford, Phil L.; Rogers, Tom D.; Shullenberger, C. C.; Howe, Clifton D.

doi:10.1002/1097-0142(196510)18:10<1345::aid-cncr2820181021>3.0.co;2-j

Cited by 53 publications

(5 citation statements)

References 22 publications

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“…Mycoplusma-like Particles in Clinical Material. Particles morphologically similar t o mycoplasma were reported in tissues of patients with leukemia (Dalton et al, 1964a;Dmochowski, 1965a,b;Dmochowski et al, 1964Dmochowski et al, , 1965Grace et al, 1965;Seman and Dmochowski, 1965).…”

mentioning

confidence: 55%

Mycoplasma and Leukemia

Barile

1967

Annals of the New York Academy of Sciences

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confidence: 55%

Mycoplasma and Leukemia

Barile

1967

Annals of the New York Academy of Sciences

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“…The ability of human tumor cells to release virus particles although of interest is usually a rare and transient occurrence (68). However, in one case myeloid cells from a patient with AML were cultured for several weeks under conditions that allowed the cells to maintain their differentiated state and to grow exponentially.…”

Section: Virus Markers In Human Cancermentioning

confidence: 99%

RNA Processing and RNA Tumor Virus Origin and Evolution

Gillespie

Gallo

1975

Science

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The results of molecular hybridization experiments with high-molecular-weight RNA isolated from RNA tumor viruses and DNA from normal cells suggest that RNA tumor virus genomes originate from cell genes. Some RNA tumor viruses (here called class 1) appear to have been generated in recent times in that their RNA is closely related in nucleotide sequence to certain cell genes (class 1 genes). A second class of RNA tumor viruses (here called class 2) is more distantly related to genomic information of normal cells. Structural properties of the RNA of RNA tumor viruses lead us to propose that the tumor virus RNA is originated when RNA transcripts of class 1 genes are processed by a mechanism we call "paraprocessing." We postulate that RNA paraprocessing is normally used only at particular times during differentiation and is characterized by the cytoplasmic appearance of high-molecular-weight RNA chains containing terminal polyadenylic acid (200 residues). Paraprocessing of class 1 gene transcripts in committed or differentiated cells is considered to be aberrant in transcription that can lead to the generation of an RNA tumor virus genome. If the paraprocessed class 1 gene transcript codes for a reverse transcriptase, replication of the RNA becomes possible. Transfer of the replicating RNA to a new cell can result in genetic change such that the virus genome mutates, differing from the original progenitor genes. We propose that this genetic change causes class 1 viruses to become class 2. These ideas are applied to evidence concerning the biology of infection of RNA tumor viruses and concerning the involvement of RNA tumor viruses in human cancer. Genetic change can also occur during the origination of an RNA tumor virus genome by repeated reverse transcription and recombination (45) or by genetic alteration of particularly changeable cell genes ("hot spots") (43).

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“…Direct investigation of human tumour cells or leukaemic plasma by the electron microscopy has not proved very useful. Particles resembling animal C-type RNA tumour viruses have been described (Dmochowski et al, 1965;Gross, 1970), but the possibility that these observations are artifacts cannot be disputed since the tumours were not assayed for biological activity.…”

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confidence: 99%

Purification, biochemical characterization and serological analysis of cellular deoxyribonucleic acid polymerases and a reverse transcriptase from spleen of a patient with myelofibrotic syndrome

Prakash¹,

Steel²

1977

Biochemical Journal

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The present study describes the separation and purification of a reverse transcriptase and cellular DNA polymerases from the human spleen of a patient with myelofibrotic syndrome. The specific requirements with respect to bivalent cations and template-primers for DNA polymerase-alpha, DNA polymerase-beta and DNA polymerase-gamma, as well as for the reverse transcriptase, are reported. Sedimentation-velocity measurements of the purified enzymes gave values of 150000, 40000, 100000 and 70000 daltons for DNA polymerase-alpha DNA polymerase-beta, DNA polymerase-gamma and the reverse transcriptase respectively. Serological studies have shown that the reverse transcriptase from human spleen is not antigenically related to cellular DNA polymerase-alpha, -beta or -gamma, but is antigenically related to reverse transcriptase from simian sarcoma virus and gibbon-ape leukaemia virus.

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Viruses and mycoplasma (PPLO) in human leukemia

Cited by 53 publications

References 22 publications

Mycoplasma and Leukemia

Mycoplasma and Leukemia

RNA Processing and RNA Tumor Virus Origin and Evolution

Purification, biochemical characterization and serological analysis of cellular deoxyribonucleic acid polymerases and a reverse transcriptase from spleen of a patient with myelofibrotic syndrome

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