Viruses and cancer: Herpesviruses and tumors in the head and neck

Scully, Crispian

doi:10.1016/0030-4220(83)90010-5

Cited by 25 publications

(4 citation statements)

References 110 publications

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“…Gradually, however, the unexpected consequences of some oral viral infections have emerged and been recognised, not without some surprise (Scully, 1983) especially the oncogenicity of some herpesviruses (Eglin et al, 1983) and human papillomaviruses (HPVs) which we (Eglin et al, 1983;Maitland et al, 1987;Cox et al, 1993) and many others (e.g. Lind et al, 1986) have explored, culminating in the appreciation of unanticipated transmission routes for some cancers, such as sexual (Scully, 2002).…”

Section: Introductionmentioning

confidence: 99%

Emerging and changing viral diseases in the new millennium

Scully¹,

Samaranayake

2015

Oral Diseases

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Most viral infections encountered in resource‐rich countries are relatively trivial and transient with perhaps fever, malaise, myalgia, rash (exanthema) and sometimes mucosal manifestations (enanthema), including oral in some. However, the apparent benignity may be illusory as some viral infections have unexpected consequences – such as the oncogenicity of some herpesviruses and human papillomaviruses. Infections are transmitted from various human or animal vectors, especially by close proximity, and the increasing movements of peoples across the globe, mean that infections hitherto confined largely to the tropics now appear worldwide. Global warming also increases the range of movement of vectors such as mosquitoes. Thus recent decades have seen a most dramatic change with the emergence globally also of new viral infections – notably human immunodeficiency viruses (HIV) – and the appearance of some other dangerous and sometimes lethal infections formerly seen mainly in, and reported from, resource‐poor areas especially in parts of Asia, Latin America and Africa. This study offers a brief update of the most salient new aspects of the important viral infections, especially those with known orofacial manifestations or other implications for oral health care.

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Section: Introductionmentioning

confidence: 99%

Emerging and changing viral diseases in the new millennium

Scully¹,

Samaranayake

2015

Oral Diseases

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“…There is considerable evidence that OSCC is generally etiologically associated with tobacco and/or alcohol or betel use, but there are clearly patients who develop OSCC in the absence of exposure to these and in the absence of any obvious predisposing genetic defect 6–8 . Microbial agents are possible etiological agents 9 , and nearly two decades ago, Scully C et al 10,11 . produced the first evidence for the presence of viral nucleic acids in OSCC tissues, hypothesising that there may be a viral association in, at least, some OSCC as in anogenital cancer 12,13 .…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus infection in oral squamous cell carcinomas: correlation with histologic variables and survival outcome in a high risk population

et al. 2008

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Aim: Cancer of the oral cavity is extremely prevalent in Pakistan. Human papillomavirus (HPV) has been shown to play a role in the development of oral squamous cell carcinoma (OSCC) and may even improve overall and disease-free survival. The purpose of this study was to determine prevalence and types of HPV in a high risk population and its correlation with overall and disease-free survival, chewing habits and histologic variables. Material and methods: A total of 140 patients of OSCC, having a long-term follow-up, were included in this study. HPV-general and type-specific 16 and 18 infection were investigated by means of polymerase chain reaction. Results: Out of 140 patients, HPV was detected in 95 (68%) patients, out of whom, 85 (90%) contained HPV16. HPV positive patients had comparatively prolonged overall survival when compared with HPV-negative patients, but this difference was not statistically significant (P = 0.97). HPV presence was also not found to correlate significantly with disease-free survival (P = 0.58). The male were significantly correlated [odds ratio (OR) = 2.34; 95% confidence interval (CI) = 1.13–4.84] with the HPV infection. Betel quid chewer were comparatively more prone to HPV positivity (OR = 2; 95% CI = 1.1–4.31). Conclusion: Our study found a high prevalence of HPV16 in OSCC of Pakistani patients with male sex showing significant correlation with HPV infection. However, we did not find a statistically significant favourable association between HPV, survival and histologic variables. Borderline significance of HPV positivity was also seen with betel quid chewing (P = 0.049

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“…Many can be oncogenic. Oral disease associations examined have ranged from carcinogenesis 111,112 to periodontitis. 113…”

Section: Herpesvirusesmentioning

confidence: 99%