Viruses and Breast Cancer

Lawson, James S.; Heng, Benjamin

doi:10.3390/cancers2020752

Cited by 49 publications

(55 citation statements)

References 79 publications

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“…The detection of HPV in breast cancer is consistent with 15 (of 17) previous publications reporting the presence of HPV in breast cancer world-wide with a prevalence of ranging from 4 -86% (Lawson et al, 2006). Given such a high proportion of studies reporting HPV in breast cancer and breast tissue, the question is why some (2 of 17) studies report that HPV is not present in breast cancer.…”

Section: Discussionsupporting

confidence: 84%

“…Previous studies have demonstrated the presence of HPV high-risk types 16, 18 and 33 in breast cancer specimens from diverse populations around the world: Italy, Norway, China, Japan, USA, Austria, Brazil, Australia, Taiwan, Turkey, Greece, Korea, Mexico, Hungary and Syria (Lonardo et al, 1992;Hennig et al, 1999;Yu et al, 1999;Liu et al, 2001;Damin et al, 2004;Widschwendter et al, 2004;de Villiers et al, 2005;Kan et al, 2005;Tsai et al, 2005;Gumus et al, 2006;Kroupis et al, 2006;Lawson et al, 2006;Choi et al, 2007;Akil et al, 2008;Khan et al, 2008;Kulka et al, 2008;MendizabalRuiz et al, 2009). The prevalence of HPV positive breast cancer in these studies was reported to vary from 4% in Mexican to 86% in American women.…”

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confidence: 99%

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Human papilloma virus is associated with breast cancer

et al. 2009

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BACKGROUND: There is increasing evidence that high-risk human papilloma virus (HPV) is involved in cancers in addition to cervical cancer. For example, it is generally accepted that HPV has a role in a significant proportion of head and neck tumours, and it has long been hypothesised that hormone dependent oncogenic viruses, such as HPV may have causal roles in some human breast cancers. A number of reports have identified HPV DNA in breast tissue and breast cancer specimens, but these rely on standard polymerase chain reaction (PCR), which is criticised for its propensity for contamination. METHODS: We have used two different technologies, in situ and standard PCR (with sequencing), and histology based on light microscopy. RESULTS: We unambiguously demonstrate the presence of high-risk HPV in the cells of breast cancer specimens and breast cancer cell lines. In addition, we also show that the oncogenic characteristics of HPV associated breast cancer are very similar to HPV-associated cervical cancer. Specifically, that putative koilocytes are present in some HPV associated breast cancers. INTERPRETATION: The above observations indicate a likely causal role for high-risk HPV in human breast cancer and offer the possibility of primary prevention of some breast cancers by vaccination against HPV.

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Section: Discussionsupporting

confidence: 84%

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confidence: 99%

Human papilloma virus is associated with breast cancer

et al. 2009

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“…Such evidence may provide opportunities for the pathogenesis, early detection and prevention of breast cancer (5,58,59). In particular, along with the reports of worse prognosis of EBV DNA positive patients than the negative patients (12,34,37), this can be applied to the treatment of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Epstein-Barr Virus Infection and Risk of Breast Cancer: An Adaptive Meta-Analysis for Case-Control Studies

Bae

Kim

2016

Arch Clin Infect Dis

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Context: The association between 'Epstein-Barr' virus (EBV) and breast cancer risk still remains controversial. A Systemic Review (SR) published in 2012 reported that there might be a statistically significant association between EBV and risk of breast cancer. However, errors were found in the appraisal process of the concerned SR. Objectives:The aim of this report was to conduct an adaptive meta-analysis with additional extraction of relevant papers published up until September 2015.Data Sources: The lists of references, cited articles and related articles provided by PubMed were made using the articles selected in the previous SR.Study Selection: Among these articles, only case-control studies using Polymerase Chain Reaction (PCR) techniques to detect EBV DNA in tissues were selected. Data Extraction: The summary odds ratio (SOR) and the 95% confidence interval (CI) were calculated though meta-analysis.Results: A total of 20 case-control studies were selected, and the total numbers of subjects in the case and control groups were 1947 and 1010, respectively. The findings of this meta-analysis revealed that EBV infection might increase the risk of breast cancer (SOR = 3.84, 95% CI: 2.24-6.58; I-squared = 62.2%). Sub-group analyses by region, sample type, and control tissue showed that a statistical significance of the risk was still secured. Conclusions:The findings of the meta-epidemiological study support that EBV infection may increase the risk of breast cancer. Nested case-control studies are required in the future.

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“…Although we used the TaqMan realtime PCR and MMTV isolate as a positive control, we did not detect MMTV in our CMT tissue samples. This difference may be due to the previously described relationship between MMTV and BC and the presence of house mouse in the domestic or work environment (13,23). Stewart et al (21) predicted that "people who live and work where Mus domesticus is especially common should have a higher MMTV sero-prevalence than those not so directly exposed to mice".…”

Section: Methodsmentioning

confidence: 99%

“…Due to these effects, Lawson and Heng (13) believed that the scientific issue has evolved from "are viruses present in BC?" to "are viruses in BC oncogenic or harmless passengers?"…”

Section: Introductionmentioning

confidence: 99%

Investigation of human papillomaviruses (HPV), mouse mammary tumour virus (MMTV), Epstein–Barr virus (EBV), and human polyomavirus entities in canine mammary tumours

Sönmez¹,

Altan

Yıldırım³

et al. 2016

Journal of Veterinary Research

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Introduction: The aim of the study was to investigate the presence of human papillomaviruses (HPV), mouse mammary tumour virus (MMTV), Epstein-Barr virus (EBV), and human polyomavirus BK in canine mammary tumours (CMTs) and to correlate the results of histopathological classification with the results of virological examination. Material and Methods: Eighty CMTs and ten normal canine mammary gland samples were evaluated using histopathological methods and TaqMan real-time PCR analysis. Results: The results indicated that all mammary tumours and normal mammary tissue samples were negative for HPV16 and other HPV, EBV, human polyomavirus, and human mammary tumour virus strains. Conclusion: Further studies should be performed to investigate the existence of other strains of HPV, EBV, and human polyomavirus in CMTs.

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Viruses and Breast Cancer

Cited by 49 publications

References 79 publications

Human papilloma virus is associated with breast cancer

Human papilloma virus is associated with breast cancer

Epstein-Barr Virus Infection and Risk of Breast Cancer: An Adaptive Meta-Analysis for Case-Control Studies

Investigation of human papillomaviruses (HPV), mouse mammary tumour virus (MMTV), Epstein–Barr virus (EBV), and human polyomavirus entities in canine mammary tumours

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