Viruses and Bioterrorism ☆

Morse, Stephen; Meyer, Richard F.

doi:10.1016/b978-0-12-809633-8.11007-6

Cited by 4 publications

(2 citation statements)

References 46 publications

(57 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are more than 1,400 species of infectious organisms that are known to be pathogenic to humans and capable of causing disease in animals and plants (19). Staphylococcus aureus and Staphylococcus albus are the most commonly bacteria that cause infections in hospitals (20).…”

Section: Discussionmentioning

confidence: 99%

Environmental Management Strategy to Control Air Germs in Tjitrowardojo District Hospital

Praptiwi

Rahardjo

Sunarto

2021

JKL

View full text Add to dashboard Cite

Introduction: The presence of air germs in the hospital patient rooms is potentially to cause health problems for patients. This study aimed to identify andanalyze environmental factors associated with air germs, and formulate environmental management strategi to control air germs in the patient rooms. Methods: This study was an observational analytic survey, used a mixed method and a cross sectional design. Data collection was conducted through laboratory tests and interviews. Data was analysed by pearson correllation test to analyze environmental factors associated with air germs. The appropriate environmental management strategies was determined through SWOT analysis (Strength, Weakness, Opportunities, Threats). Results and Discussion: Several factors related to air germs were temperature (p = 0.032), lighting (p = 0.01) and the staff knowledge (p = 0.001). Humidity was not significantly related to air germs (p = 0.178), The results of SWOT analysis indicated that aggressive strategies (Strengths and Opportunities) were arranging internal hospital policies regarding to air quality management based on the Ministry of Health, utilizing educational qualifications and knowledge of room staff to support policy implementation, improving the performance of outsourcing personnel in cleaning services and maintaining hospitals infrastructure, increasing Inhouse Training activities. Conclusion: Environmental factors play an important role in the presence of air germs in the patient rooms so appropriate environmental management strategies are needed to control the presence of air germs.

show abstract

Section: Discussionmentioning

confidence: 99%

Environmental Management Strategy to Control Air Germs in Tjitrowardojo District Hospital

Praptiwi

Rahardjo

Sunarto

2021

JKL

View full text Add to dashboard Cite

show abstract

“…Monkeypox (MPOXV) is the causative agent of a current outbreak ( 3 ). Retaining infectivity as aerosols and/or droplets, VEEV, filoviruses, and MPOXV are considered bioterrorism threats ( 2 , 4 ). The current lack of effective intervention strategies against the majority of emerging viruses leaves the global and military populations unprepared for future pandemics.…”

Section: Introductionmentioning

confidence: 99%

Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects

Saul¹,

Karim²,

Ghita³

et al. 2023

Journal of Clinical Investigation

View full text Add to dashboard Cite

Targeting host factors exploited by multiple viruses could offer broad-spectrum solutions for pandemic preparedness. Seventeen candidates targeting diverse functions emerged in a screen of 4,413 compounds for SARS-CoV-2 inhibitors. We demonstrated that lapatinib and other approved inhibitors of the ErbB family of receptor tyrosine kinases suppress replication of SARS-CoV-2, Venezuelan equine encephalitis virus (VEEV), and other emerging viruses with a high barrier to resistance. Lapatinib suppressed SARS-CoV-2 entry and later stages of the viral life cycle and showed synergistic effect with the direct-acting antiviral nirmatrelvir. We discovered that ErbB1, ErbB2, and ErbB4 bind SARS-CoV-2 S1 protein and regulate viral and ACE2 internalization, and they are required for VEEV infection. In human lung organoids, lapatinib protected from SARS-CoV-2–induced activation of ErbB-regulated pathways implicated in non-infectious lung injury, proinflammatory cytokine production, and epithelial barrier injury. Lapatinib suppressed VEEV replication, cytokine production, and disruption of blood-brain barrier integrity in microfluidics-based human neurovascular units, and reduced mortality in a lethal infection murine model. We validated lapatinib-mediated inhibition of ErbB activity as an important mechanism of antiviral action. These findings reveal regulation of viral replication, inflammation, and tissue injury via ErbBs and establish a proof of principle for a repurposed, ErbB-targeted approach to combat emerging viruses.

show abstract

The GCBR After COVID-19

Kambouris

2024

Advanced Sciences and Technologies for Security Applications

View full text Add to dashboard Cite

Viruses and Bioterrorism ☆

Cited by 4 publications

References 46 publications

Environmental Management Strategy to Control Air Germs in Tjitrowardojo District Hospital

Environmental Management Strategy to Control Air Germs in Tjitrowardojo District Hospital

Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects

The GCBR After COVID-19

Contact Info

Product

Resources

About