Viruses and atypical bacteria associated with asthma exacerbations in hospitalized children

Maffey, Alberto; Barrero, Paola Roxana; Venialgo, Carolina; Fernández, Francisco Arnalich; Fuse, Valentina; Saia, Mariana; Villalba, Analía; Fermepin, Marcelo Rodríguez; Teper, Alejandro; Mistchenko, Alicia

doi:10.1002/ppul.21236

Cited by 59 publications

(48 citation statements)

References 29 publications

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“…de HBoV como causa de crisis asmáticas también ha sido sugerido por algunos trabajos [26][27][28] . El antecedente de asma o sibilancias recurrentes estaba presente en alrededor de 1/3 de nuestros pacientes, tanto en los que tenían HBoV como agente único, como en los co-infectados con virus que clásicamente se presentan con sibilancias (VRS).…”

Section: Discussionunclassified

Bocavirus humano en Chile: características clínicas y epidemiológicas en niños con infecciones respiratorias

et al. 2011

Rev. chil. infectol.

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Background: Human bocavirus (HBoV) is a newly discovered parvovirus found in children with acute respiratory tract infections (ARTI). Objectives: To describe the epidemiological and clinical profi le of children < 5 years old consulting for ARTI, comparing cases of HBoV monoinfection and coinfection with other known respiratory viruses. Furthermore, we aimed to estimate the prevalence of viral shedding in asymptomatic children and perform phylogenetic analysis. Patients and Methods: We investigated the presence of HBoV in nasopharyngeal secretions from children consulting for ARTI and among asymptomatic controls, between 2007 and 2008, by polymerase chain reaction. Results: HBoV was detected in 79 (21.8%) of 362 nasopharyngeal swabs obtained from children with ARTI. In 60/79 (76%), coinfection with other respiratory viruses was confi rmed. Most common symptoms were cough, fever and rhinorrhea. Children infected only with HBoV showed signifi cantly lower frequencies of respiratory distress, oxygen requirements and hospital admission than those with coinfection. HBoV was detected in 6/16 (37.5%) samples from asymptomatic children. The phylogenetic analysis of viruses from Chilean patients revealed that circulating HBoV was closely related to original strains. Conclusions: HBoV was found either in symptomatic and asymptomatic children. The severity of the disease was greater when HBoV was associated to other respiratory viruses.

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Section: Discussionunclassified

Bocavirus humano en Chile: características clínicas y epidemiológicas en niños con infecciones respiratorias

et al. 2011

Rev. chil. infectol.

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“…In hospitalized children aged between 3 and 16 years, HRV and HRSV were the most frequent viruses in nasopharynx secretion during asthma exacerbations (10). Similarly, a Japanese group also demonstrated that HRSV was related to wheezing episodes and was more frequent in patients with a history of asthma (11).…”

Section: The Prevalence Of Viruses In the Airwaysmentioning

confidence: 97%

Viruses and bacteria in Th2‐biased allergic airway disease

Feng

Zhang

Gevaert

et al. 2016

Allergy

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Allergic airway diseases are typically characterized by a type 2-biased inflammation. Multiple distinct viruses and bacteria have been detected in the airways. Recently, it has been confirmed that the microbiome of allergic individuals differs from that of healthy subjects, showing a close relationship with the type 2 response in allergic airway disease. In this review, we summarize the recent findings on the prevalence of viruses and bacteria in type 2-biased airway diseases and on the mechanisms employed by viruses and bacteria in propagating type 2 responses. The understanding of the microbial composition and postinfectious immune programming is critical for the reconstruction of the normal microflora and immune status in allergic airway diseases.

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“…Acute atypical bacteria are closely correlated with acute asthma attacks, and chronic MP infection plays a particularly important role in persistent asthma (Blasi and Johnston, 2007;Sutherland and Martin, 2007;Korppi, 2010;Maffey et al, 2010). An association between MP and more severe asthma exacerbation has also been observed in a previous study (Cosentini et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Effects of Mycoplasma pneumoniae infection on airway neurokinin-1 receptor expression in BALB/c mice

Zhang¹,

Wei²,

Shang³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to establish a BALB/c mouse model of Mycoplasma pneumoniae (MP) infection and to explore the expression of neurokinin-1 receptor (NK1-R) in the trachea and lung tissue and changes in its relative content at different time points (on the 3rd, 7th, 14th, 21st, and 30th days after infection) in MP-infected BALB/c mice. Immunohistochemistry and Western blot analysis were performed to determine NK1-R expression in the trachea and lung tissue and changes in relative content in MP-infected BALB/c mice. After MP infection, the expression of NK1-R on the surfaces of upper tracheal and bronchial epithelial cells, submucosa, and alveolar epithelial cells, as well as around the smooth muscle, was upregulated more significantly in the infection group than in the control group (P < 0.05); NK1-R protein expression was enhanced on the 3rd, 7th, 14th, 21st, and 30th days after infection compared with that of the control 8321 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (4): 8320-8328 (2014) MP infection on airway NK1-R expression in BALB/c mice group (P < 0.05). NK1-R expression in the trachea, bronchus, and lung tissue increased in MP-infected BALB/c mice, which may explain why wheezing occurs after MP infection.

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Viruses and atypical bacteria associated with asthma exacerbations in hospitalized children

Abstract: Children with an acute asthma exacerbation presented a high prevalence of respiratory viruses. Most hospitalizations corresponded to seasonal increases in prevalence of HRV and HRSV.

Cited by 59 publications

References 29 publications

Bocavirus humano en Chile: características clínicas y epidemiológicas en niños con infecciones respiratorias

Bocavirus humano en Chile: características clínicas y epidemiológicas en niños con infecciones respiratorias

Viruses and bacteria in Th2‐biased allergic airway disease

Effects of Mycoplasma pneumoniae infection on airway neurokinin-1 receptor expression in BALB/c mice

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