Virus-sampling technologies in different environments

Nourmoradi, Heshmatollah; Mohammadi‐Moghadam, Fazel; Hemati, Sara; Kakaei, Hojatollah

doi:10.1016/b978-0-323-85780-2.00010-x

Cited by 2 publications

(1 citation statement)

References 86 publications

(111 reference statements)

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“…The PCR-based tests are applied widely to detect the singlestranded RNA virus SARS-CoV-2 during the COVID-19 pandemic. Sampling techniques such as swab sampling and bronchoalveolar lavage are adopted to collect specimens from the environments and individuals 2 (Liao et al, 2020;Nourmoradi et al, 2021;Rahmani et al, 2020). Electrospun polymer composites are considered good materials for developing highly efficient sampling strategies, particularly swab sampling.…”

Section: Virus Sampling and Detectionmentioning

confidence: 99%

Antiviral Electrospun Polymer Composites: Recent Advances and Opportunities for Tackling COVID-19

Wang

Jiang

et al. 2021

Front. Mater.

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The ongoing COVID-19 pandemic caused by SARS-CoV-2 has significantly affected the world, creating a global health emergency. For controlling the virus spread, effective and reliable diagnostic and therapeutic measures are highly expected. Using proper biomedical materials to produce detection kits/devices and personal protective equipment (PPE), such as swabs and masks, has become the focus since they play critical roles in virus diagnostics and prevention. Electrospun polymer composites have garnered substantial interest due to their potential to provide antiviral healthcare solutions. In this review, we summarized the recent efforts in developing advanced antiviral electrospun polymer composites for virus detection and prevention. We highlighted some novel strategies for developing effective antiviral personal protective equipment (PPE), including self-sterilization, reusability, and potential antiviral drug encapsulation. Besides, we discussed the current challenges and future perspectives for improving the materials’ performance to achieve better virus detection, antiviral, prevention, and therapeutics.

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Section: Virus Sampling and Detectionmentioning

confidence: 99%

Antiviral Electrospun Polymer Composites: Recent Advances and Opportunities for Tackling COVID-19

Wang

Jiang

et al. 2021

Front. Mater.

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25 Years Responding to Respiratory and Other Viruses with Mass Spectrometry

Downard

2023

Mass Spectrometry

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This review article presents the development and application of mass spectrometry (MS) approaches, developed in the author’s laboratory over the past 25 years, to detect; characterise, type and subtype; and distinguish major variants and subvariants of respiratory viruses such as influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). All features make use of matrix-assisted laser desorption ionisation (MALDI) mass maps, recorded for individual viral proteins or whole virus digests. A MALDI-based immunoassay in which antibody–peptide complexes were preserved on conventional MALDI targets without their immobilisation led to an approach that enabled their indirect detection. The site of binding, and thus the molecular antigenicity of viruses, could be determined. The same approach was employed to study antivirals bound to their target viral protein, the nature of the binding residues, and relative binding affinities. The benefits of high-resolution MS were exploited to detect sequence-conserved signature peptides of unique mass within whole virus and single protein digests. These enabled viruses to be typed, subtyped, their lineage determined, and variants and subvariants to be distinguished. Their detection using selected ion monitoring improved analytical sensitivity limits to aid the identification of viruses in clinical specimens. The same high-resolution mass map data, for a wide range of viral strains, were input into a purpose-built algorithm (MassTree) in order to both chart and interrogate viral evolution. Without the need for gene or protein sequences, or any sequence alignment, this phylonumerics approach also determines and displays single-point mutations associated with viral protein evolution in a single-tree building step.

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Virus-sampling technologies in different environments

Cited by 2 publications

References 86 publications

Antiviral Electrospun Polymer Composites: Recent Advances and Opportunities for Tackling COVID-19

Antiviral Electrospun Polymer Composites: Recent Advances and Opportunities for Tackling COVID-19

25 Years Responding to Respiratory and Other Viruses with Mass Spectrometry

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