Abstract:In patients with moderate to severe coronavirus disease 2019 (COVID-19), both proteinuria and high plasma levels of soluble urokinase receptor (suPAR) are commonly observed. Here we show a new type of proteinuria originating as part of a viral response. Inoculation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused increased suPAR levels and glomerulopathy in African Green Monkeys. We developed a unique mouse model whereby inhaled variants of the SARS-CoV-2 spike S1 protein elicited protein… Show more
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