Virus propagation linked to exceedingly rare gene-expression errors
Raquel Luzón-Hidalgo,
Gianluca d’Agostino,
Valeria A. Risso
et al.
Abstract:Viruses are obligate parasites that establish extensive interactions with proteins and other biomolecules of their hosts. About 20% of protein molecules bear phenotypic mutations due to errors during gene expression. Phenotypic mutations are not inherited and are not purged/amplified by natural selection. Therefore, protein variants harboring phenotypic mutations remain at very low levels. Here, we show that proteins at exceedingly low levels may enable virus propagation. Bacteriophage T7 recruits the host thi… Show more
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