Virus Pneumonia of Infants Secondary to Epidemic Infections

Goodpasture, Ernest W.; Auerbach, Sanford H.; Swanson, Holly; Cotter, E. F.

doi:10.1001/archpedi.1939.01990050003001

Cited by 30 publications

(10 citation statements)

References 5 publications

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“…Nevertheless, RSV immunostaining was able to confirm infection in tissue that was more than 65 years old. Although Dr Ernest Goodpasture described cases of virus pneumonia consistent with RSV infection in 1939, 9 our case from 1931 is the earliest confirmed case of RSV infection ever reported. Unfortunately, attempts to extract viral RNA from the archival samples for amplification and sequencing as recently achieved for the 1918 strain of influenza 10 were unsuccessful.…”

Section: Discussionmentioning

confidence: 54%

The histopathology of fatal untreated human respiratory syncytial virus infection

et al. 2007

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The pathology of respiratory syncytial virus (RSV) infection was evaluated 1 day after an outpatient diagnosis of RSV in a child who died in a motor vehicle accident. We then identified 11 children with bronchiolitis from the Vanderbilt University autopsy log between 1925 and 1959 who met criteria for possible RSV infection in the preintensivist era. Their tissue was re-embedded and evaluated by routine hematoxylin and eosin and PAS staining and immunostaining with RSV-specific antibodies. Tissue from three cases was immunostain-positive for RSV antigen and was examined in detail. Small bronchiole epithelium was circumferentially infected, but basal cells were spared. Both type 1 and 2 alveolar pneumocytes were also infected. Although, not possible for archival cases, tissue from the index case was evaluated by immunostaining with antibodies to define the cellular components of the inflammatory response. Inflammatory infiltrates were centered on bronchial and pulmonary arterioles and consisted of primarily CD69 þ monocytes, CD3 þ double-negative T cells, CD8 þ T cells, and neutrophils. The neutrophil distribution was predominantly between arterioles and airways, while the mononuclear cell distribution was in both airways and lung parenchyma. Most inflammatory cells were concentrated submuscular to the airway, but many cells traversed the smooth muscle into the airway epithelium and lumen. Airway obstruction was a prominent feature in all cases attributed to epithelial and inflammatory cell debris mixed with fibrin, mucus, and edema, and compounded by compression from hyperplastic lymphoid follicles. These findings inform our understanding of RSV pathogenesis and may facilitate the development of new approaches for prevention and treatment.

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Section: Discussionmentioning

confidence: 54%

The histopathology of fatal untreated human respiratory syncytial virus infection

et al. 2007

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“…The first written description of the syndrome appears to be in 1826 [12], although it is likely RSV is an ancient disease and was not easily discriminated from other causes of acute respiratory disease in children. Goodpasture et al described the pathology in 1939 [13] and Adams provided the first clinical description of the disease in the microbial era [14,15]. …”

Section: Historymentioning

confidence: 99%

Vaccine development for respiratory syncytial virus

Graham

2017

Current Opinion in Virology

146

114

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Respiratory syncytial virus (RSV) is an important and ubiquitous respiratory pathogen for which no vaccine is available notwithstanding more than 50 years of effort. It causes the most severe disease at the extremes of age and in settings of immunodeficiency. Although RSV is susceptible to neutralizing antibody, it has evolved multiple mechanisms of immune evasion allowing it to repeatedly infect people despite relatively little genetic diversity. Recent breakthroughs in determining the structure and antigenic content of the fusion (F) glycoprotein in its metastable untriggered prefusion form (pre-F) and the stable rearranged postfusion form (post-F) have yielded vaccine strategies that can induce potent neutralizing antibody responses and effectively boost pre-existing neutralizing activity. In parallel, novel live-attenuated and chimeric virus vaccine candidates and other novel approaches to deliver vaccine antigens have been developed. These events and activities have aroused optimism and a robust pipeline of potential vaccine products that promise to provide a means to reduce the public health burden of RSV infection.

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“…Four of the fatal cases studied appeared to be pathologic ally identical to a viral pneumonia described by Goodpasture and character ized by specifi c intranuclear inclusion bodies in cells of the pulmonary lesions (13,14). The fatal cases in Paris were associated with type 7a in fections (15); however, other fatal pneumonias have been associated with the isolation of serotypes 1, 2, 3, and 18 in the United States (24,39), Eng land (43), and Holland (43).…”

Section: S9mentioning

confidence: 63%