Virus-Like Structures in Lupus Erythematosus

Kawano, Kinya; Miller, Leonard P.; Kimmelstiel, Paul

doi:10.1056/nejm196911272812207

Cited by 108 publications

(21 citation statements)

References 1 publication

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“…Their mean age was 40. 6 The complement-fixation (CF) test for antibodies to measles and rubella viral antigens' was performed by a modified microtiter procedure using a dilution of antigen containing four complementfixing units (22). For control purposes, dilutions of known positive and negative sera were included with each test antigen.…”

Section: Methodsmentioning

confidence: 99%

Antibodies to Viral Antigens in Systemic Lupus Erythematosus

Hollinger

Sharp

Lidsky

et al. 1971

Arthritis & Rheumatism

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Sera from 31 patients with lupus erythematosus, 31 controls matched by age and sex and 33 patients with connective tissue disorders other than SLE were examined for specific antibodies to 15 viral antigens by hemagglutination-inhibition tests. Complement-fixation tests were also employed t o measure antibodies to measles virus and rubella virus. Sera from patients with LE had significantly higher geometric mean antibody titers than matched controls to measles, rubella, parainfluenza types 2 and 3 and reovirus type 2 antigens. When antibody levels from patients with LE were compared with those from patients with other connective tissue disorders, significant differences were noted for measles, rubella, parainfluenza types 1 and 2 and mumps antigens. Removal of nonspecific antinuclear antibodies from selected SLE sera by adsorption with mouse liver nuclear antigens failed to appreciably alter specific viral antibody. The elevated antibody levels in sera from patients with SLE are consistent with the existence of a hyperreactive immunologic state in this disorder and do not necessarily carry etiologic implications.

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Section: Methodsmentioning

confidence: 99%

Antibodies to Viral Antigens in Systemic Lupus Erythematosus

Hollinger

Sharp

Lidsky

et al. 1971

Arthritis & Rheumatism

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“…Despite a superficial resemblance to the nucleoprotein cores of myxoviruses (1,2,8,22), the tubules observed in endothelial cells and lymphocytes of patients with SLE appear to lack the helical periodicity of myxovirus cores (25,28,30). In this respect, the tubules also differ from the intranuclear filaments described in chronic polymyositis or subacute sclerosing panencephalitis (31,32).…”

Section: Nature and Pathogenesis Of Trsmentioning

confidence: 94%

Abnormal Structures in Circulating Lymphocytes from Patients with Systemic Lupus Erythematosus and Related Diseases

Grimley

Decker

Michelitch

et al. 1973

Arthritis & Rheumatism

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A prospective electron microscopic study, incorporating blind controls, demonstrated tubuloreticular structures (TRS) in the buffy coat lymphocytes of 32 patients with connective tissue disease. From 1 to 8% of the lymphocyte sections were involved. The abnormal structures consisted of interwoven, electron-dense tubules (220 to 280 A diameter) which were located within the endoplasmic reticulum. Tubuloreticular structures were found in lymphocytes from 20 of 30 patients with systemic lupus erythematosus (SLE), 2 of 4 with discoid lupus erythematosus, 8 of 20 with other connective tissue disease and none of 22 control cases. Clinical evaluation of the patients with SLE disclosed no specific differences between those with TRS-positive or TRS-negative lymphocytes; there were some indications of greater disease activity in the TRS-positive group. The biologic nature of TRS is unknown, but they have been linked to virus infection under both clinical and experimental conditions. systemic lupus erythematosus (SLE) (3-6) and many patients with related diseases of connective tissues (7-9). We now report a significant frequency of morphologically identical structures in the circulating lymphocytes of such patients.T h e tubules in question have been distinguished by their ultrastructural appearance. They are relatively electron-dense and measure in the range of 220 to 280 A in diameter. They are interwoven within membrane-limited compartments which can often be identified as dilatations of the endoplasmic reticulum or perinuclear space. T h e biologic nature of these structures is still unknown, and we have adopted the description tu buloreticular struclures (TRS) also proposed by Dalton (1 0).T h e possibility of finding T R S in circulating cells was suggested by electron microscopic examination of a skin biopsy from a 24-year-old man with SLE with subcutaneous nodules and histologic evidence of chronic vasculitis. Thin

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“…They were found in lupus nephritis [5][6][7][8]12], in the active skin lesions of chronic and systemic lupus erythematosus [2,10,19,20], in scleroderma [17], and also in polymyositis and dermatomyositis [1,3,9,11,14,17,21,23], Furthermore, they have been described in some cases of autoimmunological syndromes -Sjogren's syndrome [24], and also in the congenital rubella [10], Virus-like structures have also been reported in lymphomas -reticuloses and mycosis fungoides [22],…”

Section: Rna Viruses Cytoplasmic Inclusions Tubular Inclusions Epithementioning

confidence: 99%

Virus-Like Tubular Cytoplasmic Inclusions in Epithelial Tumors

Maciejewski¹,

Dąbrowski²,

Jabłońska³

et al. 1973

Dermatology

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Electron microscopic studies were made in 11 cases of benign epithelial tumors (common warts, seborrheic warts, and papilloma) and malignant ones (Bowen’ disease and basal cell epithelioma). Characteristic tubular inclusions were detected chiefly in the cytoplasm of vascular endothelial cells in 6 cases (common warts, papilloma, Bowen’s disease, and basal cell epithelioma). Morphologically, they resembled paramyxoviruses and were exactly similar to those described in collagen diseases, chiefly in lupus erythematosus.

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Virus-Like Structures in Lupus Erythematosus

Cited by 108 publications

References 1 publication

Antibodies to Viral Antigens in Systemic Lupus Erythematosus

Antibodies to Viral Antigens in Systemic Lupus Erythematosus

Abnormal Structures in Circulating Lymphocytes from Patients with Systemic Lupus Erythematosus and Related Diseases

Virus-Like Tubular Cytoplasmic Inclusions in Epithelial Tumors

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