Virus-like particles in a human ameloblastoma

Csiba, A; Okrös, I; Dzsinich, Csaba; Szabó, Dénes

doi:10.1016/0003-9969(70)90154-8

Cited by 19 publications

(5 citation statements)

References 17 publications

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“…2 In humans, viral elements have been identified in ameloblastomas. 6 and evidence has been presented that links human ameloblastomas to papillomaviruses 28 and Epstein-Barr virus. 18 In the current situation, we present subcellular structures that are possible viral particles; expert opinions that we have solicited vary widely.…”

Section: Discussionmentioning

confidence: 99%

Epizootic Ameloblastomas in Chinook Salmon (Oncorhynchus tshawytscha) of the Northwestern United States

et al. 2009

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Abstract. Abnormal growths were observed on the lips and in the oral cavities of 2-and 3-year-old Chinook salmon (Oncorhynchus tshawytscha) maintained in one freshwater and one saltwater captive fish-rearing facility in the Columbia River (Pacific Northwest). Initially presenting as bilaterally symmetrical, red, irregular plaques on oral mucosal surfaces, the lesions developed progressively into large, disfiguring masses. Of the 502 natural parr collected for captive broodstock, 432 (86%) displayed these tumors, whereas cohort salmon (i.e., same year classes) in these same facilities remained unaffected. Morphologically similar neoplasms were collected occasionally from adult Chinook salmon that had returned to their natal streams. Histologic features of the tumors suggested that they were derived from the portion of dental lamina destined to form tooth root sulci; therefore, these neoplasms were diagnosed as ameloblastomas. The lesions also resembled archived specimens of Chinook salmon oral tumors, which had been described decades earlier. Etiologic investigations performed during the current outbreak included bacteriologic, virologic, genetic, ultrastructural analyses, and cohabitation exposure studies. Results of these efforts did not indicate an obvious genetic basis for this syndrome, attempts to isolate potentially causative viruses or bacteria were negative, and disease transmission to naïve fish was unsuccessful. A few intracytoplasmic hexagonal structures, possibly consistent with viral particles (,100 nm), were observed ultrastructurally in a tumor cell from 1 of 6 specimens submitted for transmission electron microscopy. Although the presence of these particles does not constitute sufficient evidence for causality, an infectious or multifactorial etiology seems plausible.

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Section: Discussionmentioning

confidence: 99%

Epizootic Ameloblastomas in Chinook Salmon (Oncorhynchus tshawytscha) of the Northwestern United States

et al. 2009

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“…6,22 In humans, viral elements have been identified in cases of ameloblastoma, and a link to papillomavirus and Epstein-Barr virus has been proposed. [28][29][30] Similarly, viral elements were suspected on histologic samples obtained during an epizootic outbreak of ameloblastomas in Chinook salmon. 21 The inciting cause of ameloblastoma formation in the Asiatic black bear in this report is unknown but may have been associated with the previous dental disease and/or extractions.…”

Section: Discussionmentioning

confidence: 99%

Maxillary Ameloblastoma in an Asiatic Black Bear (Ursus thibetanus)

McCleery¹,

Thurber

Lux

et al. 2023

J Vet Dent

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An approximately 30-year-old intact female Asiatic black bear ( Ursus thibetanus) was presented for annual examination and a history of ptyalism. A large 9.5 cm × 5 cm × 5 cm, firm, round mass was identified attached to the hard palate on physical examination. A computed tomography scan was performed, and the heterogeneous, mineral-attenuating mass was seen arising from the right aspect of the palatine bone and extending rostrally to the level of the last maxillary molars, caudally into the oropharynx, and dorsally into the nasal choana. Surgical debulking was performed to remove the portion of the mass within the oral cavity. Histopathologic analysis was consistent with a keratinizing ameloblastoma. Nine months postoperatively, the patient was asymptomatic for the tumor. The patient was euthanized 23-months postoperatively, and severe diffuse pustular dermatitis, growth of the ameloblastoma on the hard palate, and various degenerative and aging changes were noted on necropsy at that time. This is the first report of an ameloblastoma in a member of the Ursidae family.

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“…Viral pathogenesis also indicated by Stanley's team (1964), in animal experiments in 1966 by Main and Dave. They observed neoplastic growths alleged to be counterparts of ameloblastoma with the aid of using injection of the polyoma virus 23 .This study will help the clinician to diagnose ameloblastoma on the basis of radiographic features of the lesion and adjacent teeth.…”

Section: Introductionmentioning

confidence: 85%

Radiographic Appearance and Root Resorption Caused by Ameloblastoma in pts attending Teaching Institute of Dentistry

Jehan¹,

Shoaib²,

Afzal³

et al. 2023

PJMHS

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Background: Odontogenic tumors represent the heterogeneous organization of lesions with numerous histopathological characteristics and medical manifestations. Ameloblastoma is real neoplasm of odontogenic epithelium, constitute one percentage of oral complete ectodermal tumors &9percentage of an odontogenic tumors4. This tumor is benign, which suggests the insidious slowly increase, regionally aggressive having excessive recurrence rate5 Aim: To evaluate radiographical features and root resorption among patients of Ameloblastoma reporting to Dept. of OMFS Study Design: Descriptive Cross-Sectional Study Place and duration of study: Department of Oral and Maxillofacial surgery, Multan Dental College Multan. Duration of this study was 2 years from 1st Jan 2021 to 31th Dec 2022. Methodology: A descriptive audit including all patient records with a histo-pathologically confirmed report of ameloblastoma based on the routine Hematoxylin and Eosin stain. Consecutive non-probability sampling technique was used. Results: One hundred and forty people with an ameloblastoma were contained within ours study amongst whom 45(32.1%) were female and 95(67.9%) were men. 123(87.9%) lesions were found in the mandible. Swelling was mostly told symptoms in 137(97.8%) of all cases. 76(54.3%) showed root resorption. Radiographically, the multilocular appearance accounted for 97(69.3%) while uni-loculancy was present in 43(30.7%) of the lesions. Practical implication: This study help in diagnosis of amelolastoma. This also guides the clinician to differentiate different forms of aelolastoma and differentially diagnose from other radiolucent lesions. Conclusion: This study pointed that ameloblastoma was seen more in men when compared with females Most cases showed root resorption. Mostly ameloblastomas were of multi-locular form/pattern with posterior are of lower jaw as most frequent site involved. Keywords: Ameloblastoma, features, radiolucency & Multi-locular

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Virus-like particles in a human ameloblastoma

Cited by 19 publications

References 17 publications

Epizootic Ameloblastomas in Chinook Salmon (Oncorhynchus tshawytscha) of the Northwestern United States

Epizootic Ameloblastomas in Chinook Salmon (Oncorhynchus tshawytscha) of the Northwestern United States

Maxillary Ameloblastoma in an Asiatic Black Bear (Ursus thibetanus)

Radiographic Appearance and Root Resorption Caused by Ameloblastoma in pts attending Teaching Institute of Dentistry

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