Virus-inspired nucleic acid delivery system: Linking virus and viral mimicry

Ni, Rong; Hossain, Naushad; Chau, Ying

doi:10.1016/j.addr.2016.07.005

Cited by 70 publications

(51 citation statements)

References 311 publications

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“…deliver their nucleic acid (DNA or RNA) into a host cell for replication. There are numerous viral agents that could be selected for this purpose, each with some unique attributes that would make them more or less suitable for the task, depending on the desired profile [ 1 ]. However, the undesired properties of some viral vectors, including their immunogenic profiles or their propensity to cause cancer have resulted in serious clinical adverse events and, until recently, limited their current use in the clinic to certain applications, for example, vaccines and oncolytic strategies [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Adeno-Associated Virus (AAV) as a Vector for Gene Therapy

et al. 2017

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There has been a resurgence in gene therapy efforts that is partly fueled by the identification and understanding of new gene delivery vectors. Adeno-associated virus (AAV) is a non-enveloped virus that can be engineered to deliver DNA to target cells, and has attracted a significant amount of attention in the field, especially in clinical-stage experimental therapeutic strategies. The ability to generate recombinant AAV particles lacking any viral genes and containing DNA sequences of interest for various therapeutic applications has thus far proven to be one of the safest strategies for gene therapies. This review will provide an overview of some important factors to consider in the use of AAV as a vector for gene therapy.

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Section: Introductionmentioning

confidence: 99%

Adeno-Associated Virus (AAV) as a Vector for Gene Therapy

et al. 2017

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“…These agents have naturally developed a perfect capacity to deliver nucleic acids to the host cells. A variety of viruses with unique properties allows choosing the most appropriate vehicle for each application [125,126]. However, certain viral vectors may cause significant side effects.…”

Section: Viral Vectorsmentioning

confidence: 99%

Emerging Concepts and Challenges in Rheumatoid Arthritis Gene Therapy

et al. 2020

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Rheumatoid arthritis (RA) is a systemic inflammatory joint disease affecting about 1% of the population worldwide. Current treatment approaches do not ensure a cure for every patient. Moreover, classical regimens are based on nontargeted systemic immune suppression and have significant side effects. Biological treatment has advanced considerably but efficacy and specificity issues remain. Gene therapy is one of the potential future directions for RA therapy, which is rapidly developing. Several gene therapy trials done so far have been of moderate success, but experimental and genetics studies have yielded novel targets. As a result, the arsenal of gene therapy tools keeps growing. Currently, both viral and nonviral delivery systems are used for RA therapy. Herein, we review recent approaches for RA gene therapy.

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“…For instance, light‐harvesting complexes serve as a beautiful example showing how the organization of chromophores is instrumental for directing the cascade of energy and electron transfer processes . Viruses constitute another striking example, for which a precise number of proteins forming a capsid are arranged with a high level of organization around the genomic nucleic acid, which is essential for its delivery, and assembly/disassembly processes . Recently, researchers have reported many examples in the fields of electronics, sensing, delivery, and catalysis that illustrate emerging collective properties arising from supramolecular organizations occurring at different levels .…”

Section: Introductionmentioning

confidence: 99%

From Interaction to Function in DNA‐Templated Supramolecular Self‐Assemblies

Surin

Ulrich

2020

ChemistryOpen

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DNA-templated self-assembly represents a rich and growing subset of supramolecular chemistry where functional selfassemblies are programmed in a versatile manner using nucleic acids as readily-available and readily-tunable templates. In this review, we summarize the different DNA recognition modes and the basic supramolecular interactions at play in this context. We discuss the recent results that report the DNA-templated self-assembly of small molecules into complex yet precise nanoarrays, going from 1D to 3D architectures. Finally, we show their emerging functions as photonic/electronic nanowires, sensors, gene delivery vectors, and supramolecular catalysts, and their growing applications in a wide range of area from materials to biological sciences.[a] Dr.

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Virus-inspired nucleic acid delivery system: Linking virus and viral mimicry

Cited by 70 publications

References 311 publications

Adeno-Associated Virus (AAV) as a Vector for Gene Therapy

Adeno-Associated Virus (AAV) as a Vector for Gene Therapy

Emerging Concepts and Challenges in Rheumatoid Arthritis Gene Therapy

From Interaction to Function in DNA‐Templated Supramolecular Self‐Assemblies

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