Virus-induced eosinophil mediator release requires antigen-presenting and CD4+ T cells

Davoine, Francis; Cao, Min; Wu, Yingqi; Ajamian, Farnam; Ilarraza, Ramses; Kokaji, Andy I.; Moqbel, Redwan; Adamko, Darryl J.

doi:10.1016/j.jaci.2008.03.028

Cited by 50 publications

(48 citation statements)

References 52 publications

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“…42 The precise mechanisms via which Af (but not ova) primes eosinophils to respond to virus infection remain to be explored. Of note, Davoine et al 43 reported that human eosinophils interact with parainfluenza virus and release peroxidase only when in coculture with antigen presenting cells and CD4…”

Section: Discussionmentioning

confidence: 99%

Activated mouse eosinophils protect against lethal respiratory virus infection

Percopo

Dyer

Ochkur

et al. 2014

Blood

109

105

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Section: Discussionmentioning

confidence: 99%

Activated mouse eosinophils protect against lethal respiratory virus infection

Percopo

Dyer

Ochkur

et al. 2014

Blood

109

105

View full text Add to dashboard Cite

show abstract

“…1). The eosinophil granule proteins ECP and EDN degrade single-stranded RNA viruses via ribonuclease activity; viruses including rhinovirus, respiratory syncytial virus (RSV), and parainfluenza virus induce eosinophil release of EPO in the presence of CD4 T cells and antigen-presenting cells (15). Eosinophils appear to be important in the innate immune response during bacterial sepsis originating from an intestinal source.…”

Section: Infectionmentioning

confidence: 99%

Eosinophils and Cancer

Davis

Rothenberg

2014

Cancer Immunology Research

218

171

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Eosinophils have long been known to infiltrate tumors, and in most cases, this is associated with an improved prognosis. However, the reasons behind this infiltration and the mechanism of action of the eosinophil have remained elusive. In this article, we explore the biology of eosinophils and examine their function in homeostasis and disease states, specifically focusing on what is currently known about the association of the eosinophil with cancer. Cancer Immunol Res; 2(1); 1-8. Ó2014 AACR. Disclosure of Potential Conflicts of InterestM.E. Rothenberg has an ownership Interest in Immune Pharmaceuticals and Receptos; is a consultant/advisory board member of Immune Pharmaceuticals, Norvatis, Pluristem Therapeutics, and Receptos; and has royalty to reslizumab (Teva Pharmaceuticals). No potential conflicts of interest were disclosed by the other author. CME Staff Planners' DisclosuresThe members of the planning committee have no real or apparent conflicts of interest to disclose. Learning ObjectivesEosinophils, discovered over 150 years ago, are present in various lesions, and tumor-associated tissue eosinophilia has been correlated with both good and bad prognosis for cancer. Upon completion of this activity, the participant should gain a basic knowledge of the biology of eosinophils, and their potential roles in homeostasis and in diseases. A broader understanding of these granulocytic leukocytes and their interaction with other immune cells will inform research on their potential to affect tumors and to improve cancer therapy.

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“…74,75 (3) Ex vivo studies using purified proteins in both viral infection studies in culture and several in vivo animal studies of viral infection have mechanistically linked antiviral eosinophil activities to the release of secondary granule proteins. These include the demonstration that eosinophil-associated ribonucleases displayed antiviral activities toward single-stranded RNA viruses, 76 the observations that major basic protein 77 and eosinophil peroxidase (EPX) 78 each appear to provide unique antiviral activities in mouse models of viral infection, and eosinophil activation may be linked with the binding of viral ligands to Toll-like receptors on eosinophils. 79 In summary, these studies suggest that eosinophils in both humans and mice may have a potential contributory role(s) to the immune responses associated with viral vaccination/infection as either a fundamental innate host response to viral infection, a component of acquired immune responses to viral infection, and/or a contributor to host remodeling/repair required in the recovery phase post-infection.…”

Section: Responses To Respiratory Viral Infectionmentioning

confidence: 99%

The expanding role(s) of eosinophils in health and disease

Jacobsen¹,

Helmers

Lee³

et al. 2012

Blood

180

154

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Surprisingly, the role(s) of eosinophils in health and disease is often summarized by clinicians and basic research scientists as a pervasive consensus opinion first learned in medical/graduate school. Eosinophils are rare white blood cells whose activities are primarily destructive and are only relevant in parasitic infections and asthma. However, is this consensus correct? This review argues that the wealth of available studies investigating the role(s) of eosinophils in both health and disease demonstrates that the activities of these granulocytes are far more expansive and complex than previously appreciated. In turn, this greater understanding has led to the realization that eosinophils have significant contributory roles in a wide range of diseases. Furthermore, published studies even implicate eosinophil-mediated activities in otherwise healthy persons. We suggest that the collective reports in the literature showing a role for eosinophils in an everincreasing number of novel settings highlight the true complexity and importance of this granulocyte. Indeed, discussions of eosinophils are no longer simple and more often than not now begin with the question/statement "Did you know . . .?" (Blood. 2012;120(19):3882-3890)

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Virus-induced eosinophil mediator release requires antigen-presenting and CD4+ T cells

Cited by 50 publications

References 52 publications

Activated mouse eosinophils protect against lethal respiratory virus infection

Activated mouse eosinophils protect against lethal respiratory virus infection

Eosinophils and Cancer

The expanding role(s) of eosinophils in health and disease

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