Virus-induced cochlear inflammation in newborn mice alters auditory function

Sung, Cathy Yea Won; Seleme, Maria C.; Payne, Shelby; Jonjić, Stipan; Hirose, Keiko; Britt, William J.

doi:10.1172/jci.insight.128878

Cited by 32 publications

(26 citation statements)

References 39 publications

(76 reference statements)

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“…Besides genetic causes, congenital infections as cytomegalovirus (cCMV) account for a large amount of children suffering from bilateral sensorineural hearing loss (15–20%) [35] . Infections of a neonatal mouse model with moderate amounts of CMV identified SGN loss underlying hearing impairment [36] .…”

Section: Disease Mechanismsmentioning

confidence: 99%

“…via notch inhibitors) [79] . Regeneration of SGNs by OPC transplantation in patients with major loss of SGNs, as in the case of congenital CMV infected children [ 36 , 80 ], could improve hearing restoration by cochlear implants. Moreover, transplantation of OPCs derived from genome-edited iPSC lines carrying channelrhodopsins such as f-Chrimson [58] could then be used in combination with optical CIs ( Fig.…”

Section: Disease Mechanismsmentioning

confidence: 99%

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Understanding and treating paediatric hearing impairment

2021

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Section: Disease Mechanismsmentioning

confidence: 99%

Section: Disease Mechanismsmentioning

confidence: 99%

Understanding and treating paediatric hearing impairment

2021

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“…Interestingly, MCMV was cleared in the cochlea by 14 days post-infection (dpi), but HC loss occurred between 14 and 21 dpi. This postponed HC loss suggests that the inflammatory response might be responsible for the HC death [ 13 , 14 , 15 , 16 , 17 ], but the cell death pathways are still unclear. Hearing loss was further demonstrated to be correlated with the expression of MCMV-induced proinflammatory cytokines and chemokines, but not the viral load in the cochlea [ 8 ].…”

Section: Hearing Loss and Hcmv Infectionmentioning

confidence: 99%

“…In MCMV-infected mice, these neurites connecting the cochlear HC and SGN nerve terminals were disrupted by MCMV induced inflammation in cochlear. This impairment could be mitigated by treating MCMV-infected mice with anti-inflammatory drug corticosteroid between P3–P20, which preserved HC-SGN synapse density and improved hearing [ 16 , 28 ]. It would be very interesting to see whether CMV infection or CMV-induced inflammation disrupts Cx43 expression in SGN neurites and how this interaction is involved in CMV-induced hearing loss in animal models.…”

Section: Hcmv May Induce Hearing Loss Through Connexin 43 Suppressionmentioning

confidence: 99%

Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways

Huang

Zhou

Jiang

et al. 2021

Viruses

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Hearing loss is one of the most prevalent sensory disabilities worldwide with huge social and economic burdens. The leading cause of sensorineural hearing loss (SNHL) in children is congenital cytomegalovirus (CMV) infection. Though the implementation of universal screening and early intervention such as antiviral or anti-inflammatory ameliorate the severity of CMV-associated diseases, direct and targeted therapeutics is still seriously lacking. The major hurdle for it is that the mechanism of CMV induced SNHL has not yet been well understood. In this review, we focus on the impact of CMV infection on the key players in inner ear development including the Wnt and Notch signaling pathways. Investigations on these interactions may gain new insights into viral pathogenesis and reveal novel targets for therapy.

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“…inoculation has been described, and the protection afforded by CD4 + T cells [ 143 ], CD8 + T cells [ 144 ], and antibodies [ 130 ] has been noted. This model has provided important information about sensorineural hearing loss [ 132 ]. Latent MCMV in brain tissue has been reactivated in brain slices in a culture from mice infected as newborn pups [ 145 ].…”

Section: Murine Cytomegalovirus Infection As a Model For Human Cytmentioning

confidence: 99%

A Review of Murine Cytomegalovirus as a Model for Human Cytomegalovirus Disease—Do Mice Lie?

Fisher

Lloyd

2020

IJMS

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Since murine cytomegalovirus (MCMV) was first described in 1954, it has been used to model human cytomegalovirus (HCMV) diseases. MCMV is a natural pathogen of mice that is present in wild mice populations and has been associated with diseases such as myocarditis. The species-specific nature of HCMV restricts most research to cell culture-based studies or to the investigation of non-invasive clinical samples, which may not be ideal for the study of disseminated disease. Initial MCMV research used a salivary gland-propagated virus administered via different routes of inoculation into a variety of mouse strains. This revealed that the genetic background of the laboratory mice affected the severity of disease and altered the extent of subsequent pathology. The advent of genetically modified mice and viruses has allowed new aspects of disease to be modeled and the opportunistic nature of HCMV infection to be confirmed. This review describes the different ways that MCMV has been used to model HCMV diseases and explores the continuing difficulty faced by researchers attempting to model HCMV congenital cytomegalovirus disease using the mouse model.

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Virus-induced cochlear inflammation in newborn mice alters auditory function

Cited by 32 publications

References 39 publications

Understanding and treating paediatric hearing impairment

Understanding and treating paediatric hearing impairment

Hearing Loss Caused by HCMV Infection through Regulating the Wnt and Notch Signaling Pathways

A Review of Murine Cytomegalovirus as a Model for Human Cytomegalovirus Disease—Do Mice Lie?

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