Dana Avrahami, Yael Dayan-Amouyal, Saar Tal, Michal Mincberg, Claytus Davis, Oded Abramsky, Ruth Gabizon
Abstract:Prion diseases are fatal neurodegenerative disorders characterized by long incubation periods. To investigate whether concurrent diseases can modify the clinical outcome of prion-affected subjects, we tested the effect of viral infection on the binding and internalization of PrP(Sc), essential steps of prion propagation. To this effect, we added scrapie brain homogenate or purified PrP(Sc) to fibroblasts previously infected with minute virus of mice (MVM), a mouse parvovirus. We show here that the rate of inco…
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