Virus-Encoded Circular RNAs: Role and Significance in Viral Infections
Giuseppe Sberna,
Fabrizio Maggi,
Alessandra Amendola
Abstract:Circular RNAs (circRNAs) have been the focus of intense scientific research to understand their biogenesis, mechanisms of action and regulatory functions. CircRNAs are single stranded, covalently closed RNA molecules lacking the 5′-terminal cap and the 3′-terminal polyadenine chain, characteristics that make them very stable and resistant. Synthesised by both cells and viruses, in the past circRNAs were considered to have no precise function. Today, increasing evidence shows that circRNAs are ubiquitous, some … Show more
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