Virus-associated granulocytomas in the marine mussel, Mytilus edulis, from three sites in Denmark

Rasmussen, Lars P.D.

doi:10.1016/0022-2011(86)90150-3

Cited by 31 publications

(19 citation statements)

References 8 publications

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“…Virus-like have been reported by Jones et al (1996) in New Zealand and Rasmussen (1986) in Denmark. Also, viruses-like have been reported as category 1 in Canada Fisheries, meaning that they are agents of infectious diseases, which can have serious impact on shellfish stocks, as indicated by Bower (2010).…”

Section: Resultsmentioning

confidence: 80%

Report of pathogens and parasites in Perumytilus purpuratus from San Jorge Bay, Antofagasta, Chile

Montenegro¹,

Jones²,

González³

2012

Rev. biol. mar. oceanogr.

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Section: Resultsmentioning

confidence: 80%

Report of pathogens and parasites in Perumytilus purpuratus from San Jorge Bay, Antofagasta, Chile

Montenegro¹,

Jones²,

González³

2012

Rev. biol. mar. oceanogr.

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“…A picorna-like virus has been found associated with granulocytomas in Danish M. edulis. The 27 nm virus particles form paracrystalline arrays and the mitochondria of affected areas often contain non-viral associated crystalline inclusions (Rasmussen 1986, Bower & Figueras 1989. The absence of mitochondnal inclusions and arrays and the characteristic proliferation of ER suggests that the New Zealand virus may be different from that reported in Denmark.…”

Section: Discussionmentioning

confidence: 99%

Virus-like particles associated with marine mussel mortalities in New Zealand

Jones¹,

Scotti²,

Dearing³

et al. 1996

Dis. Aquat. Org.

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ABSTRACT. Green-lip mussel Perna canaliculus spat (15 to 30 m m length) in the outer Marlborough Sounds, New Zealand, suffered 50 to 100% mortal~t)! during January to April 1994 (summer/autumn) following thinning and reseeding of the mussel lines by farmers Adult mussel ~nortalities of 2 to 5 % continued from February to early h4ay 1994 Histolog~cal examination showed extensive haemocytosis and multifocal liquefact~on necrosls of i n t e r s t~t~a l cells, basal cells and digest~ve tubule ep~thelial cells. Sloughed pyknot~c 01-karyolyt~c digestive tubule epithelia1 cells formed charactenst~c rounded granular b o d~e s 10 to 15 pm diameter both In digestive tubules and free in lesions. No v~r a l inclusion bodies were observed Ultrastructural examination showed highly mod~fied rough endoplasn~ic reticulum assoc~ated with small, 25 to 45 nm diameter, electron-dense uncoated virus-like particles Identical cell damage and virus-like particles were subsequently found In moribund adult (75 to 110 mm length) P canallculus and stunted (25 to 47 mm length) subtidal 12-li'tilus galloprov~ncial~s from the same area.Following purification of extracts of the moribund spat b}! isopycnlc centl-ifugation in CsCI, large numbers of 25 nm diameter, unenveloped, virus pal-t~cles were scvn by electron mlcroscopy These part~cles had a density of 1.364 g cm-3 A broad band at a d e n s~t y c~xpected for enveloped particles (1 21 to 1 24 g cm ') was also observed but contained few v~rus-like particles Cell damage a n d mussel mortalit~es are thus likely due to a small unenveloped virus.

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“…Although all published picornaviruses were identified in mammals and birds, there are reports of picornavirus-like viruses of reptiles (24,25), fish (26)(27)(28)(29)(30)(31), and marine invertebrates (32)(33)(34)(35), indicating circulation of such viruses in aquatic ecosystems. Here, we describe a fish picornavirus which proves that picornavirus ecology indeed includes lower vertebrates of freshwater and probably marine ecosystems.…”

mentioning

confidence: 99%

Characterization of a Novel Picornavirus Isolate from a Diseased European Eel ( Anguilla anguilla )

Fichtner

Philipps

Groth

et al. 2013

J Virol

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A novel picornavirus was isolated from specimens of a diseased European eel (Anguilla anguilla). This virus induced a cytopathic effect in eel embryonic kidney cells and high mortality in a controlled transmission study using elvers. Eel picornavirus has a genome of 7,496 nucleotides that encodes a polyprotein of 2,259 amino acids. It has a typical picornavirus genome layout, but its low similarity to known viral proteins suggests a novel species in the family Picornaviridae.A ll members of the family Picornaviridae are small, nonenveloped, icosahedral viruses with positive-strand RNA genomes. Genome sizes range from 7,000 to 9,100 nucleotides. The 5= end of the RNA is covalently linked to a small virus-encoded peptide (3B); the 3= end is polyadenylated. The genome encodes one or two polyproteins that are processed co-and posttranslationally into 10 to 14 mature polypeptides. Cap-independent translation initiation is stimulated by one or two internal ribosome entry site (IRES) elements. Common to all picornaviruses are homologous capsid proteins and the nonstructural proteins 2C, 3Cpro , and 3Dpol . The sequences of other nonstructural proteins (leader protein, 2A, 2B, 3A, and 3B) are not conserved and may be unique to some picornavirus genera (1, 2).The family Picornaviridae is currently comprised of 37 species grouped into 17 genera (Aphthovirus, Aquamavirus, Avihepatovirus, Cardiovirus, Cosavirus, Dicipivirus, Enterovirus, Erbovirus, Hepatovirus, Kobuvirus, Megrivirus, Parechovirus, Salivirus, Sapelovirus, Senecavirus, Teschovirus, and Tremovirus; http: //ictvonline.org/). However, picornavirus taxonomy is still in flux, as next-generation sequencing technologies facilitate metagenomics studies using viral nucleic acid-containing specimens. Analysis of viral genomes without prior virus isolation led to the identification of more than 30 approved or tentative picornavirus species from humans (cosavirus [3] Although all published picornaviruses were identified in mammals and birds, there are reports of picornavirus-like viruses of reptiles (24, 25), fish (26-31), and marine invertebrates (32-35), indicating circulation of such viruses in aquatic ecosystems. Here, we describe a fish picornavirus which proves that picornavirus ecology indeed includes lower vertebrates of freshwater and probably marine ecosystems. Eel picornavirus 1 (EPV-1) was isolated from a European eel (Anguilla anguilla) from Lake Constance on the Rhine River. The viral genome contains an open reading frame (ORF) of 6,777 nucleotides (2,259 amino acids [aa]), and the predicted polyprotein displays the typical organization of a picornavirus. According to the Picornavirus Study Group criteria (www .picornastudygroup.com/definitions/genus_definition.htm), low similarity to the conserved P1 and 3CD precursor proteins of EPV-1 suggests a novel genus in the family Picornaviridae.Starting in May 2005, an increased number of diseased or dead eels were observed in fish traps and aquacultures in the Lake Constance area. Diseased fish presented with...

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Virus-associated granulocytomas in the marine mussel, Mytilus edulis, from three sites in Denmark

Cited by 31 publications

References 8 publications

Report of pathogens and parasites in Perumytilus purpuratus from San Jorge Bay, Antofagasta, Chile

Report of pathogens and parasites in Perumytilus purpuratus from San Jorge Bay, Antofagasta, Chile

Virus-like particles associated with marine mussel mortalities in New Zealand

Characterization of a Novel Picornavirus Isolate from a Diseased European Eel ( Anguilla anguilla )

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