Virus-Associated CD8
+
T-Cells Are Not Activated Through Antigen-Mediated Interaction Inside Atherosclerotic Lesions
Maaike J.M. de Jong,
Frank H. Schaftenaar,
Marie A.C. Depuydt
et al.
Abstract:INTRODUCTION:
Viral infections have been associated with the progression of atherosclerosis and CD8
+
T-cells directed against common viruses, such as influenza, Epstein-Barr virus, and cytomegalovirus, have been detected inside human atherosclerotic lesions. These virus-specific CD8
+
T-cells have been hypothesized to contribute to the development of atherosclerosis; however, whether they affect disease progression directly rem… Show more
“…In this issue of ATVB, de Jong and colleagues 9 have looked deeper into the virus-specific T-cell responses in atherosclerosis and performed an immunopeptidomic analysis to identify virus epitopes. Sequencing of 10 carotid endarterectomy samples revealed that ≈2% of T-cell receptors matched virus-associated sequences.…”
Section: Immunopeptidomic Analysis Of Mhc-i From Atherosclerotic Plaquesmentioning
“…In this issue of ATVB, de Jong and colleagues 9 have looked deeper into the virus-specific T-cell responses in atherosclerosis and performed an immunopeptidomic analysis to identify virus epitopes. Sequencing of 10 carotid endarterectomy samples revealed that ≈2% of T-cell receptors matched virus-associated sequences.…”
Section: Immunopeptidomic Analysis Of Mhc-i From Atherosclerotic Plaquesmentioning
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