Virulence type and tissue tropism of Staphylococcus strains originating from Hungarian rabbit farms

Német, Zoltán; Albert, Ervin; Nagy, Krisztina; Csuka, E.; Dán, Ádám; Szenci, O.; Hermans, Katleen; Balka, Gyula; Biksi, Imre

doi:10.1016/j.vetmic.2016.08.005

Cited by 3 publications

(12 citation statements)

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“…Moreover, fostering kits from sick does was bad practice on some farms, as it enabled contagion [ 2 ]. In the present study, we observed the worst consequences of mastitis epidemics: closing farms due to endemic outbreaks of acute mastitis and multidrug-resistant S. aureus , which has also occurred in other countries [ 47 , 48 ].…”

Section: Resultsmentioning

confidence: 82%

“…We obtained four groupings of significance: group A, 1 line with mean PCM = 7.09%, group B, 6 lines with PCM between 4.58% and 6.48%, group C with 6 lines and PCM between 3.54% and 3.96%, and group D with 4 lines and PCM between 1.29% and 3.24%. In a previous study during 2001–2003 [ 48 ], we compared the influence of the line of does on PCM, but only on farms where producers did not apply antimicrobials at kindling. Differences amongst PCM were also significant in such a study: PCM = 2.05% in the lowest, and PCM = 4.83% in the line most likely to have mastitis ( p < 0.05).…”

Section: Resultsmentioning

confidence: 99%

“…From 1986 (PCM = 9.1%) to 1996 (5.2%) the year had an enabling effect [ 8 ]; however, PCM was 4.40% during 1997–2000 [ 48 ], and 4.05% during 2001–2017.…”

Section: Resultsmentioning

confidence: 99%

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Mastitis on Rabbit Farms: Prevalence and Risk Factors

Rosell¹,

Fuente

2018

Animals

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Simple SummaryMastitis has been a subject of interest on rabbit farms. To better understand various aspects of this disease, we evaluated the work done during 2001–2017, on 531 farms in Spain and Portugal. We measured the cases of mastitis on the days of visit, with the examination of lactating females. We found an average of 4% of mastitic does; they were mostly chronic forms, since females with acute mastitis often die in a few hours. Several factors affect the occurrence of mastitis. For example, rabbit lines have different susceptibilities. The number of batches per maternity barn also influences the occurrence of disease; therefore, a single batch is better, or the duo system, which consists of moving females near parity to a clean and disinfected room. In the last 200 visited farms, we found that injectable antimicrobials were often used for the mastitis control, in addition to the hygiene practices (for example, culling diseased does and avoiding their kits being fostered).AbstractIn this cross-sectional study, prevalence of clinical mastitis (PCM) and farm-specific risk factors were determined on 531 doe rabbit farms in Spain and Portugal, from January 2001 through March 2017. The information was obtained by carrying out 2367 visits and doing physical examinations of 144,455 lactating does, sorted in 2635 cohorts. Overall mean PCM was 4.05% (CI95% [3.87–4.22]), (minimum to maximum: 0–36.00% PCM). This study suggests that PCM was influenced by the variable number of batches (a batch was a group of does served the same day), per maternity barn (p < 0.0001). The duo system (does being moved to clean disinfected barns for parturition), was also an enabling risk factor for CM. The day of service or lactation stage also affected PCM. Lastly, there was an effect of the breeds or lines (p < 0.0001); mean PCM ranged between 1.29% and 7.09%. A subset of data obtained from 200 farms visited during January 2012–March 2017, was recorded to describe the use of antimicrobials against mastitis. Changes in host, husbandry, environment, and biosecurity practices, are highlighted to provide health and welfare benefits for breeding rabbits.

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Section: Resultsmentioning

confidence: 82%

Section: Resultsmentioning

confidence: 99%

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Mastitis on Rabbit Farms: Prevalence and Risk Factors

Rosell¹,

Fuente

2018

Animals

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“…Previous studies revealed the existence of highly virulent strains (HV), which were detected in Belgium, France, Greece, Italy, Portugal and Spain [5]. Our research group previously reported the presence of such strains on Hungarian rabbit farms [6]. HV strains were identified as Staphylococcus aureus clonal complex (CC) type 121 (or sequence type 121, ST121), similar strains were known for their increased virulence, and were proven to be globally distributed [7].…”

Section: Introductionmentioning

confidence: 91%

Genomic Analysis of Staphylococcus aureus Strains Originating from Hungarian Rabbit Farms Reinforce the Clonal Origin of Various Virulence Types

Német

Albert

Dán

et al. 2020

Animals

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Staphylococcosis is one of the most important infectious diseases in rabbit medicine, especially in commercial farming. Previous studies revealed the existence of virulent variants adapted to rabbits. Typical and atypical, highly virulent as well as low virulent variants have been isolated and reported from industrial units in all major rabbit-meat-producing countries. Preceding the research focused on detecting defined nucleotide sequences, the genome of these organisms as a whole was rarely subjected to scientific investigations. The authors sequenced 51 Staphylococcus strains originating from industrial rabbit farms in Hungary. Another 12 draft genomes of rabbit isolates were constructed from read sequences available in digital repositories, and were compared based on whole-genome multilocus sequence typing. The clonal origin of highly virulent variants is confirmed, the strains from Hungary were closely related with the strains isolated in the UK, Italy, and Spain. Atypical highly virulent strains are the most prevalent in Hungary, they form a separate clonal cluster. The low virulent strains were genetically similar, but more heterogeneous than the highly virulent (HV) and aHV strains even by the traditional MLST typing scheme. Other “non-aureus” Staphylococcus species were also identified.

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“…This strain shows the multiplex PCR pattern specific for aHV S. aureus strains ( 2 ). This genotype was rarely isolated from diseased rabbits ( 3 ) but currently is the most prevalent genotype at Hungarian commercial rabbit farms ( 4 ).…”

Section: Genome Announcementmentioning

confidence: 99%