Abstract:Background
Listeria monocytogenes is a facultative anaerobic zoonotic intracellular pathogen. Pathogenicity island 4 (LIPI-4) is a newly discovered virulence gene cluster involved in the central nervous system (CNS) infection of L. monocytogenes. To explore the role of LIPI-4 in the virulence of L. monocytogenes, a frozen chicken isolate LM928 LIPI-4 gene deletion strain (ΔLIPI-4) and complement strain (CΔLIPI-4) were constructed to infect human brain microvascular endothelial cells (HCMECs). The effect of L… Show more
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