Virulence Factors and Antibiotic Resistance of Enterobacterales

Bujňáková, Dobroslava; Puvača, Nikola; Ćirković, Ivana

doi:10.3390/microorganisms10081588

Cited by 8 publications

(4 citation statements)

References 15 publications

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“…This is largely consistent with Maurice et al [58] for wild wood mice (Apodemus sylvaticus). Our findings of an increase in abundance of Fusobacteriales in response to antibiotic treatment is consistent with those for pigs [59], and a disruption to the gut microbiota, such as via infection, is known to lead to blooms of Enterobacterales in other species [60], which likely explains the increased abundance observed here. An increase in the abundance of Eubacteriales under antibiotic treatment is consistent with female BALB/c mice treated with a combination of metronidazole, ampicillin, neomycin sulphate, vancomycin, and ceftriaxone sodium [61].…”

Section: Plos Onesupporting

confidence: 88%

The effects of antibiotics and illness on gut microbial composition in the fawn-footed mosaic-tailed rat (Melomys cervinipes)

Rymer

Pillay

2023

PLoS ONE

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The gut microbiota are critical for maintaining the health and physiological function of individuals. However, illness and treatment with antibiotics can disrupt bacterial community composition, the consequences of which are largely unknown in wild animals. In this study, we described and quantified the changes in bacterial community composition in response to illness and treatment with antibiotics in a native Australian rodent, the fawn-footed mosaic-tailed rat (Melomys cervinipes). We collected faecal samples during an undiagnosed illness outbreak in a captive colony of animals, and again at least one year later, and quantified the microbiome at each time point using 16s ribosomal rRNA gene sequencing. Gut bacterial composition was quantified at different taxonomic levels, up to family. Gut bacterial composition changed between time periods, indicating that illness, treatment with antibiotics, or a combination affects bacterial communities. While some bacterial groups increased in abundance, others decreased, suggesting differential effects and possible co-adapted and synergistic interactions. Our findings provide a greater understanding of the dynamic nature of the gut microbiome of a native Australian rodent species and provides insights into the management and ethical well-being of animals kept under captive conditions.

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Section: Plos Onesupporting

confidence: 88%

The effects of antibiotics and illness on gut microbial composition in the fawn-footed mosaic-tailed rat (Melomys cervinipes)

Rymer

Pillay

2023

PLoS ONE

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“…Virulence factors of Enterobacterales or Staphylocci are based on their ability to adhere to host cells, produce toxins, and resist host immune defenses [ 59 ]. The identification of specific virulence genes is crucial for understanding the pathogenic potential and for the development of preventive strategies, effective vaccines, and novel therapeutics [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Susceptibility Profiles of Bacterial Isolates Recovered from Abscesses in Cattle and Sheep at a Slaughterhouse in Algeria

Yousfi,

Oueslati,

Daaboul

et al. 2024

Microorganisms

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Abscesses represent the most prominent emerging problem in the red meat industry, leading to great economic constraints and public health hazards. Data on etiological agents present in these purulent lesions in Algeria are very scarce. The aim of this study was to identify the bacteria responsible for these abscesses and to determine their antibiotic susceptibility profiles. A total of 123 samples of abscesses from 100 slaughtered sheep and 23 slaughtered cattle were cultured in several media. A total of 114 bacterial isolates were cultured from 103 abscesses. Bacteria were identified using MALDI–TOF, and antibiotic susceptibility was determined by the disk diffusion method on Mueller–Hinton agar. A total of 73.6% (n = 84) corresponded to Enterobacterales, of which four were multidrug-resistant (MDR). These isolates, together with Staphylococcus aureus, coagulase negative Staphylococci, and seven randomly chosen susceptible Escherichia coli isolates, were further characterized using WGS. Resistome analysis of the four MDR Enterobacterales isolates revealed the presence of OXA-48 carbapenemase in two Klebsiella pneumoniae ST985 and one E. coli ST10 isolates and a CTX-M-15 ESBL in one E. coli isolate ST1706. Two coagulase-negative Staphylococci isolates were found to carry the mecA gene. WGS showed the presence of different resistance genes and virulence genes. Our study revealed 5% of MDR Enterobacterales (including ESBLs and carbapenemases) identified from abscesses, thus urging the need for abscess monitoring in slaughterhouses.

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“…Ever since its discovery, it has been hypothesized that Y. regensburgei may possess other virulence factors common to members of the Enterobacteriaceae family such as siderophores, capsules, secretion systems, other adherence factors or the ability to produce biofilms [16]. Sahni et al were able to provide some insights into this issue [17].…”

Section: Structure and Virulence Factorsmentioning

confidence: 99%

Yokenella regensburgei—Past, Present and Future

Toc,

Costache,

Neculicioiu

et al. 2024

Antibiotics

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Yokenella regensburgei is a Gram-negative rod part of the Enterobacteriaceae family (order Enterobacterales) and a rare cause of human infections. Although improved diagnostic methods have led to an increase in reports of this elusive pathogen, information remains limited. In order to provide a better understanding of this bacterium, we developed the first comprehensive review of its biology, biochemical profile, antimicrobial resistance pattern, virulence factors, natural reservoir and involvement in various veterinary and human infections. Human infections with this bacterium are scarcely reported, most probably due to constraints regarding its identification and biochemical similarities to Hafnia alvei. Multiple systematic searches revealed 23 cases of human infection, with a seemingly worldwide distribution, mostly in middle-aged or elderly male patients, often associated with immunosuppression. To date, Y. regensburgei has been reported in skin and soft tissue infections, bacteremia and sepsis, osteoarticular infections and in others such as urinary tract and digestive infections. The unique ability of Y. regensburgei to degrade polystyrene presents a novel and promising avenue for addressing plastic pollution in the near future. However, large-scale applications of this bacterium will undoubtedly increase human exposure, highlighting the necessity for comprehensive research into its role in human and veterinary infections, pathogenicity and antibiotic resistance.

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Virulence Factors and Antibiotic Resistance of Enterobacterales

Abstract: In the class Gammaproteobacteria, Enterobacterales are Gram-negative, facultatively anaerobic bacteria [...]

Cited by 8 publications

References 15 publications

The effects of antibiotics and illness on gut microbial composition in the fawn-footed mosaic-tailed rat (Melomys cervinipes)

The effects of antibiotics and illness on gut microbial composition in the fawn-footed mosaic-tailed rat (Melomys cervinipes)

Antibiotic Susceptibility Profiles of Bacterial Isolates Recovered from Abscesses in Cattle and Sheep at a Slaughterhouse in Algeria

Yokenella regensburgei—Past, Present and Future

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