Virtual Ontogeny of Cortical Growth Preceding Mental Illness

Patel, Yash; Shin, Jean; Abé, Christoph; Agartz, Ingrid; Alloza, Clara; Alnæs, Dag; Ambrogi, Sonia; Antonucci, Linda A.; Arango, Celso; Arolt, Volker; Auzias, Guillaume; Ayesa-Arriola, Rosa; Banaj, Nerisa; Banaschewski, Tobias; Bandeira, Cibele Edom; Başgöze, Zeynep; Cupertino, Renata B.; Bau, Claiton Henrique Dotto; Bauer, Jochen; Baumeister, Sarah; Bernardoni, Fabio; Bertolino, Alessandro; Bonnín, Caterina del Mar; Brandeis, Daniel; Brem, Silvia; Bruggemann, Jason; Bülow, Robin; Bustillo, Juan; Calderoni, Sara; Calvo, Rosa; Canales‐Rodríguez, Erick J.; Cannon, Dara M.; Carmona, Susanna; Carr, Vaughan J.; Catts, Stanley V.; Chenji, Sneha; Chew, Qian Hui; Coghill, David; Connolly, Colm G.; Conzelmann, Annette; Craven, Alexander R.; Crespo‐Facorro, Benedicto; Cullen, Kathryn R.; Dahl, Andreas; Dannlowski, Udo; Davey, Christopher G.; Deruelle, Christine; Díaz‐Caneja, Covadonga M.; Dohm, Katharina; Ehrlich, Stefan; Epstein, Jeffery N.; Erwin-Grabner, Tracy; Eyler, Lisa T.; Fedor, Jennifer; Fitzgerald, Jacqueline; Foran, Will; Ford, Judith M.; Fortea, Lydia; Fuentes‐Claramonte, Paola; Fullerton, Janice M.; Furlong, Lisa S; Gallagher, Louise; Gao, Bingchen; Gao, Si; Goikolea, José Manuel; Gotlib, Ian H.; Goya-Maldonado, Roberto; Grabe, Hans J.; Green, Melissa; Grevet, Eugênio H.; Groenewold, Nynke A.; Grotegerd, Dominik; Gruber, Oliver; Haavik, Jan; Hahn, Tim; Harrison, Ben J; Heindel, Walter; Henskens, Frans; Heslenfeld, Dirk J.; Hilland, Eva; Hoekstra, Pieter J.; Hohmann, Sarah; Holz, Nathalie E.; Howells, Fleur M.; Ipser, Jonathan; Jahanshad, Neda; Jakobi, Babette; Jansen, Andreas; Janssen, Joost; Jonassen, Rune; Kaiser, Anna; Каледа, В. Г.; Karantonis, James A; King, Joseph A.; Kircher, Tilo; Kochunov, Peter; Koopowitz, Sheri-Michelle; Landén, Mikael; Landrø, Nils Inge; Lawrie, Stephen M.; Лебедева, И. С.; Luna, Beatriz; Lundervold, Astri J.; MacMaster, Frank P.; Maglanoc, Luigi A.; Mathalon, Daniel H.; McDonald, Colm; McIntosh, Andrew; Meinert, Susanne; Michie, Patricia T.; Mitchell, Philip B.; Moreno‐Alcázar, Ana; Mowry, Bryan; Muratori, Filippo; Nabulsi, Leila; Nenadić, Igor; Tuura, Ruth; Oosterlaan, Jaap; Overs, Bronwyn; Pantelis, Christos; Parellada, Mara; Pariente, José; Pauli, Paul; Pergola, Giulio; Piarulli, Francesco Maria; Picon, Felipe Almeida; Piras, Fabrizio; Pomarol‐Clotet, Edith; Pretus, Clara; Quidé, Yann; Raduà, Joaquim; Ramos-Quiroga, Josep Antoni; Rasser, Paul E.; Reif, Andreas; Retico, Alessandra; Roberts, Gloria; Rossell, Susan L.; Rovaris, Diego Luiz; Rubia, Katya; Sacchet, Matthew D.; Salavert, J.; Salvador, Raymond; Sarró, Salvador; Sawa, Akira; Schall, Ulrich; Scott, Rodney J.; Selvaggi, Pierluigi; Silk, Tim; Sim, Kang; Škoch, Antonín; Spalletta, Gianfranco; Španiel, Filip; Stein, Dan J.; Steinsträter, Olaf; Stolicyn, Aleks; Takayanagi, Yoichiro; Tamm, Leanne; Tavares, Maria Eduarda de Araujo; Teumer, Alexander; Thiel, Katharina; Thomopoulos, Sophia I.; Tomeček, David; Tomyshev, Alexander; Tordesillas‐Gutiérrez, Diana; Tosetti, Michela; Uhlmann, Anne; Rheenen, Tamsyn E Van; Vázquez‐Bourgon, Javier; Vernooij, Meike W.; Vieta, Eduard; Vilarroya, Óscar; Weickert, Cynthia Shannon; Weickert, Thomas; Westlye, Lars T.; Whalley, Heather; Willinger, David; Winter, Alexandra; Wittfeld, Katharina; Yang, Tony T.; Yoncheva, Yuliya N.; Zijlmans, Jendé L.; Hoogman, Martine; Franke, Barbara; Rooij, Daan van; Buitelaar, Jan K.; Ching, Christopher R. K.; Andreassen, Ole A.; Pozzi, Elena; Veltman, Dick J.; Schmaal, Lianne; Erp, Theo G.M. van; Turner, Jessica; Castellanos, F. Xavier; Pausová, Zdenka; Thompson, Paul M.; Paus, Tomáš

doi:10.1016/j.biopsych.2022.02.959

Cited by 20 publications

(8 citation statements)

References 67 publications

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“…This is a quite big effect, of a magnitude relevant for explaining a substantial portion of the differences typically seen between patients with neurodevelopmental or neurodegenerative diseases and healthy controls. As noted, BW differences have been reported for neurodevelopmental disorders such as ADHD (41), and also other neurodevelopmental disorders, such as schizophrenia or more general psychopathology, with the cortical effects detected not invariably being very large in absolute terms (42). There is a limit to the range of variation that can apply to human cortical volumes, in general, (e.g.…”

Section: Discussionmentioning

confidence: 95%

“…CC-BY-NC-ND 4.0 International license perpetuity. It is made available under a preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in The copyright holder for this this version posted December 2, 2022. ; https://doi.org/10.1101/2022.12.02.514196 doi: bioRxiv preprint neurodevelopmental disorders, such as schizophrenia or more general psychopathology, with the cortical effects detected not invariably being very large in absolute terms (42). There is a limit to the range of variation that can apply to human cortical volumes, in general, (e.g.…”

Section: Discussionmentioning

confidence: 99%

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Back to the future: omnipresence of fetal influence on the human brain through the lifespan

Walhovd

Krogsrud

Amlien

et al. 2022

Preprint

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Human fetal development has been associated with brain health at later stages. It is unknown whether and how consistently growth in utero, as indexed by birth weight (BW), relates to lifespan brain characteristics and changes, and to what extent these influences are of a genetic and/or environmental nature. We hypothesized that associations of BW and structural brain characteristics persist through the lifespan, with topographically consistent effects across samples of varying age and origin, that BW is not protective against atrophy in aging, and that effects are partly environmental. The associations of BW and cortical area, thickness, volume and their change were investigated vertex-wise in developmental (ABCD), older adult and aging (UKB) and lifespan (LCBC) longitudinal samples. In total, 5794 persons (4-82 years, w/ 386 monozygotic twins), were followed for up to 8.3 years, yielding 12,088 brain MRIs. Positive associations between BW and cortical surface area and volume were remarkably stable through the lifespan, within and across samples of different origin, with spatial correlations in the range r = .51- .79. In contrast, there was modest and no consistent effect of BW on brain changes. Effects of BW discordance in the monozygotic twin subsample indicated the effects were partly environmental. In conclusion, the influence of prenatal growth on cortical topography is stable through the lifespan, and is reliably seen in development, adulthood, and aging. These findings support early life influence on the brain through the lifespan according to a threshold model of brain reserve, rather than a maintenance model.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Back to the future: omnipresence of fetal influence on the human brain through the lifespan

Walhovd

Krogsrud

Amlien

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Region-specific growth of the cerebral cortex was documented using detailed neuroimaging protocols based on large pediatric cohorts. These studies preceded mental illness and general psychopathology as expressed throughout childhood [ 50 ]. These MRI signatures were correlated with genome-wide association data sets.…”

Section: Adolescent Brain Maturation With Mental Health Disordersmentioning

confidence: 99%

A Bio-Social Model during the First 1000 Days Optimizes Healthcare for Children with Developmental Disabilities

Scher

2022

Biomedicines

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Most children with developmental disabilities (DD) live in resource-limited countries (LMIC) or high-income country medical deserts (HICMD). A social contract between healthcare providers and families advocates for accurate diagnoses and effective interventions to treat diseases and toxic stressors. This bio-social model emphasizes reproductive health of women with trimester-specific maternal and pediatric healthcare interactions. Lifelong neuronal connectivity is more likely established across 80% of brain circuitries during the first 1000 days. Maladaptive gene-environment (G x E) interactions begin before conception later presenting as maternal-placental-fetal (MPF) triad, neonatal, or childhood neurologic disorders. Synergy between obstetrical and pediatric healthcare providers can reduce neurologic morbidities. Partnerships between healthcare providers and families should begin during the first 1000 days to address diseases more effectively to moderate maternal and childhood adverse effects. This bio-social model lowers the incidence and lessens the severity of sequalae such as DD. Access to genetic-metabolomic, neurophysiologic and neuroimaging evaluations enhances clinical decision-making for more effective interventions before full expression of neurologic dysfunction. Diagnostic accuracy facilitates developmental interventions for effective preschool planning. A description of a mother-child pair in a HIC emphasizes the time-sensitive importance for early interventions that influenced brain health throughout childhood. Partnership by her parents with healthcare providers and educators provided effective healthcare and lessened adverse effects. Effective educational interventions were later offered through her high school graduation. Healthcare disparities in LMIC and HICMD require that this bio-social model of care begin before the first 1000 days to effectively treat the most vulnerable women and children. Prioritizing family planning followed by prenatal, neonatal and child healthcare improves wellness and brain health. Familiarity with educational neuroscience for teachers applies neurologic diagnoses for effective individual educational plans. Integrating diversity and inclusion into medical and educational services cross socioeconomic, ethnic, racial, and cultural barriers with life-course benefits. Families require knowledge to recognize risks for their children and motivation to sustain relationships with providers and educators for optimal outcomes. The WHO sustainable development goals promote brain health before conception through the first 1000 days. Improved education, employment, and social engagement for all persons will have intergenerational and transgenerational benefits for communities and nations.

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“…Disrupted gene expression in this period can produce lifelong changes in brain morphology and function. Even common genetic variations may affect early neurodevelopmental processes, thereby increasing risk for psychiatric conditions later in life ( 7 ). These effects may be detectable in early life via neuroimaging, thereby providing opportunities for identifying at-risk populations in infancy for primary prevention and the development of interventions to adjust adverse trajectories earlier in the clinical sequence.…”

mentioning

confidence: 99%

Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders

Alex

Buß

Davis

et al. 2023

Biological Psychiatry

Self Cite

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Virtual Ontogeny of Cortical Growth Preceding Mental Illness

Cited by 20 publications

References 67 publications

Back to the future: omnipresence of fetal influence on the human brain through the lifespan

Back to the future: omnipresence of fetal influence on the human brain through the lifespan

A Bio-Social Model during the First 1000 Days Optimizes Healthcare for Children with Developmental Disabilities

Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders

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