“…These include stepped wedge designs, just-in-time adaptive interventions (JITAIs, sometimes referred to as 'jedis'), (sequential) multi-randomisation trials, and 'small data' approaches. [5][6][7] As innovative interventions spread at scale, we believe We suggest therefore that HTA bodies and other stakeholders work actively towards an expansion of their instruments and funding pathways. In this discussion, a 'value-flower with 12 petals' to broaden the view of what constitutes value in healthcare has been suggested 11 adding to the well-established factors of quality-adjusted life-years, net costs, productivity, and adherence-improving factors, eight new assessments: reduction in uncertainty, fear of contagion, insurance value, severity of disease, value of hope, real option value, equity, and scientific spillovers.…”