Virtual elimination of necrotising enterocolitis for 5 years – reasons?

Patole, Sanjay; McGlone, Laura; Müller, Reinhold

doi:10.1016/s0306-9877(03)00251-2

Cited by 21 publications

(10 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although several clinical factors were associated with delays in reaching full feeds, a diagnosis of PDA or PDA and late onset sepsis was a significant risk factor. Effects of PDA, indometacin and sepsis per se as well of their interplay on intestinal perfusion and mucosal integrity may explain such results (23).…”

Section: Discussionmentioning

confidence: 99%

Does carboxymethylcellulose have a role in reducing time to full enteral feeds in preterm neonates?

Patole

Müller

2004

International Journal of Clinical Practice

View full text Add to dashboard Cite

The efficacy of prophylactic carboxymethylcellulose (CMC) in reducing the time to reach full enteral feeds (FEFs) in neonates <32 weeks' gestation was studied in a clinical trial. When ready for feeds, enrolled neonates were allocated to either CMC (dose: CMC content of 12 mg oral erythromycin ethyl succinate syrup, 6 hourly) or placebo till either maximum 10 days treatment or FEF (150 ml/kg/day) was reached. A standardised regimen guided enteral feeding. Demographic characteristics of enrolled neonates (CMC, placebo: n = 35) were comparable. Median (interquartile range) gestational age and birth weight were 29 (28, 30) vs. 29 (27, 31) weeks and 1090 (905, 1390) vs. 1236 g (928, 1565) for the CMC and placebo groups, respectively. Median (interquartile range) time to reach FEF was 5 (4, 6) vs. 5 (3, 8) days for CMC and placebo group, respectively (p = 0.5). No CMC-related adverse effects occurred. Prophylactic CMC did not have a significant role in reducing time to reach FEF.

show abstract

Section: Discussionmentioning

confidence: 99%

Does carboxymethylcellulose have a role in reducing time to full enteral feeds in preterm neonates?

Patole

Müller

2004

International Journal of Clinical Practice

View full text Add to dashboard Cite

show abstract

“…They used a standardized feeding protocol, which required feedings to be held when Indomethacin was given to close a hemodynamically significant PDA or the infant was septic. 27 …”

Section: Clinical Course Factorsmentioning

confidence: 99%

Necrotizing Enterocolitis Risk

Gephart

McGrath

Effken

et al. 2012

Advances in Neonatal Care

208

192

View full text Add to dashboard Cite

Necrotizing enterocolitis (NEC) is the most common cause of gastrointestinal-related morbidity and mortality in the neonatal intensive care unit (NICU). Its onset is sudden and the smallest, most premature infants are the most vulnerable. Necrotizing enterocolitis is a costly disease, accounting for nearly 20% of NICU costs annually. Necrotizing enterocolitis survivors requiring surgery often stay in the NICU more than 90 days and are among those most likely to stay more than 6 months. Significant variations exist in the incidence across regions and units. Although the only consistent independent predictors for NEC remain prematurity and formula feeding, others exist that could increase risk when combined. Awareness of NEC risk factors and adopting practices to reduce NEC risk, including human milk feeding, the use of feeding guidelines, and probiotics, have been shown to reduce the incidence of NEC. The purpose of this review is to examine the state of the science on NEC risk factors and make recommendations for practice and research.

show abstract

“…5 6 A significant and prolonged decline in the incidence of NEC, nearing virtual elimination in some centres, has been reported consistently since implementation of a standardised feeding regimen (SFR) in the form of clinical practice guidelines (CPG). [7][8][9][10][11] A systematic review and meta-analysis was therefore conducted to test the hypothesis that the incidence of > stage II NEC in low birthweight (LBW: birth weight ,2500 g) neonates is decreased after implementation of a SFR.…”

mentioning

confidence: 99%