Virtual Autopsy as an Alternative to Traditional Medical Autopsy in the Intensive Care Unit

Wichmann, Dominic; Obbelode, Frieder; Vogel, H.; Hoepker, Wilhelm Wolfgang; Nierhaus, Axel; Braune, Stephan; Sauter, Guido; Pueschel, Klaus; Kluge, Stefan

doi:10.7326/0003-4819-156-2-201201170-00008

Cited by 118 publications

(77 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many studies have different recruitment. For example, it is difficult to compare the results of excellent studies of hospital ITU deaths [7] compared with those from the community [15]. Likewise large studies and systematic reviews may have a very heterogeneous population, including both natural and unnatural deaths [4,16].…”

Section: Contextmentioning

confidence: 99%

“…When reviewing different studies comparing imaging and autopsy, scoring systems to deal with discrepancies are often very different. Systems have been devised to assess accuracy of clinical diagnoses compared with autopsy [35,36] and these have been adapted for use with PM imaging compared with autopsy [7]. However, these scoring systems and others used for imaging are often devised relating to technical performance or medical audit.…”

Section: What Are the Questions? How Do We Measure Accuracy Of The Anmentioning

confidence: 99%

“…Use as an adjunct places less pressure on a test, as false negatives and false positives can be identified by and challenged by the traditional tests. Both tests together will normally have greater sensitivity [7,8], and will therefore become the new gold standard. There is also growing interest in using medical imaging as a replacement for standard autopsy, both for natural and unnatural death.…”

Section: Contextmentioning

confidence: 99%

“…4: Audit of medical or institutional care: Multiple studies have shown that, even in hospital and intensive care environments, working diagnoses can be incorrect and subsequent post--mortem investigation, including imaging, can provide useful learning points [7,43,44].…”

Section: What Are the Questions? How Do We Measure Accuracy Of The Anmentioning

confidence: 99%

See 3 more Smart Citations

How does post-mortem imaging compare to autopsy, is this a relevant question?

Morgan

Rutty

2016

Journal of Forensic Radiology and Imaging

View full text Add to dashboard Cite

HighlightsEvidence of "efficacy" for a test does not imply it is effective in the real world Direct comparisons between autopsy and imaging may give misleading results Imaging is used in a wide variety of contexts, all with different questions The level of accuracy required of an imaging test depends on the context Research findings in one context may not be applicable in all contexts AbstractThe rapid development of imaging techniques used for the investigation of death invites the question "how does imaging compare with autopsy". This article is based on an invited talk given to the International Society of Forensic Radiology and Imaging in 2015 and attempts to show that this question cannot be answered, as it is in fact several questions depending on the circumstances of death. Review of the literature is fraught with difficulties due to the rapid evolution of technology, the varied circumstances of death investigation and the multiple possible post--mortem investigations that imaging can be compared with. The article focuses on the assessment of adult sudden natural death and suggests the questions that need to be answered.

show abstract

Section: Contextmentioning

confidence: 99%

Section: What Are the Questions? How Do We Measure Accuracy Of The Anmentioning

confidence: 99%

Section: Contextmentioning

confidence: 99%

Section: What Are the Questions? How Do We Measure Accuracy Of The Anmentioning

confidence: 99%

See 2 more Smart Citations

How does post-mortem imaging compare to autopsy, is this a relevant question?

Morgan

Rutty

2016

Journal of Forensic Radiology and Imaging

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5][6][7][8][9][10] Interpreting whether findings are related to cause of death requires knowledge of normal postmortem imaging findings. Postmortem computed tomography (CT) findings have been classified into 3 categories 11 -causes of death and associated changes, postmortem changes, and cardiopulmonary resuscitation-related changes.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Inversion Time for Postmortem Short-tau Inversion Recovery (STIR) MR Imaging

et al. 2014

View full text Add to dashboard Cite

Purpose: Signal intensity and image contrast differ between postmortem magnetic resonance (PMMR) images and images acquired from the living body. We sought to achieve sufficient fat suppression with short-tau inversion recovery (STIR) PMMR imaging by optimizing inversion time (TI).Material and Methods: We subjected 37 deceased adult patients to PMMR imaging at 1.5 tesla 8 to 60 hours after confirmation of death and measured T 1 values of areas of subcutaneous fat with relaxation time maps. Rectal temperature (RT) measured immediately after PMMR ranged from 6 to 31°C. We used Pearson's correlation coefficient to analyze the relationship between T 1 and relaxation time (RT). We compared STIR images from 4 cadavers acquired with a TI commonly used in the living body and another TI calculated from the linear regression of T 1 and RT.Results: T 1 values of subcutaneous fat ranged from 89.4 to 182.2 ms. There was a strong, positive, and significant correlation between T 1 and RT (r = 0.91, P < 0.0001). The regression expression for the relationship was T 1 = 2.6*RT + 90 at a field strength of 1.5T. The subcutaneous fat signal was suppressed more effectively with the optimized TI.Conclusion: The T 1 value of subcutaneous fat in PMMR correlates linearly with body temperature. Using this correlation to determine TI, fat suppression with PMMR STIR imaging can be easily improved.

show abstract

A Bloodless Coup?

Nelson¹

2013

Cancer Cytopathology

View full text Add to dashboard Cite

Virtual Autopsy as an Alternative to Traditional Medical Autopsy in the Intensive Care Unit

Abstract: University Medical Center Hamburg-Eppendorf, Germany.

Cited by 118 publications

References 28 publications

How does post-mortem imaging compare to autopsy, is this a relevant question?

How does post-mortem imaging compare to autopsy, is this a relevant question?

Optimization of Inversion Time for Postmortem Short-tau Inversion Recovery (STIR) MR Imaging

A Bloodless Coup?

Contact Info

Product

Resources

About