Virology: Isolation of a new serotype of avian reovirus associated with malabsorption syndrome in chickens

Loon, A.A.W.M. van; Koopman, H. C. (Rik); Kosman, Willeke; Mumczur, J.; Szeleszczuk, O.; Karpinska, E.; Kosowska, G.; Lütticken, D

doi:10.1080/01652176.2001.9695099

Cited by 20 publications

(15 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reoviruses may be one of several possible causative agents associated with malabsorption syndrome in chickens. The degree to which birds are affected with this disease is a result of differences in the virus-host interaction, virus pathotype, and age of the bird at time of infection (Sterner et al, 1989;Ali and Reynolds, 1997;Van Loon et al, 2001;Songserm et al, 2000Songserm et al, , 2002Songserm et al, , 2003.…”

Section: Infectious Agentsmentioning

confidence: 99%

Factors Affecting Intestinal Health in Poultry

2008

View full text Add to dashboard Cite

The gastrointestinal (GI) tract has the most extensive exposed surface in the body and is constantly exposed to a wide variety of potentially harmful substances. The GI tract acts as a selective barrier between the tissues of the bird and its luminal environment. This barrier is composed of physical, chemical, immunological, and microbiological components. A wide range of factors associated with diet and infectious disease agents can negatively affect the delicate balance among the components of the chicken gut and, as a result, affect health status and production performance of birds in commercial poultry operations. Phasing out of antibiotic growth promoters from poultry diets in Europe and recent moves toward reduction or removal of these compounds in other parts of the world including North America will likely change the microbial profile of the GI tract environment in commercial poultry. This paper reviews the GI tract from developmental, immunological, and microbial standpoints and then discusses factors that can affect health status of this system. Necrotic enteritis and coccidiosis and their interactions, and possible consequences of antibiotic growth promoter removal from poultry diets with respect to these diseases, are discussed in more detail.

show abstract

Section: Infectious Agentsmentioning

confidence: 99%

Factors Affecting Intestinal Health in Poultry

2008

View full text Add to dashboard Cite

show abstract

“…Despite many efforts to elucidate the exact cause(s) of MAS, the aetiology of MAS is yet not established although several viruses and bacteria were suspected as aetiological causes Initially, reovirus was believed to be the major causative agent of MAS and several enteric reovirus strains were identified in MAS affected chickens (Rekik et al, 1987; Malabsorption syndrome in broilers: J.M.J. Rebel et al Kouwenhoven et al, 1988;van Loon et al, 2001;Kant et al, 2003). In addition, induction of a mild form of intestinal lesions was reported in SPF chickens with enteric reovirus infection (Shirai et al, 1990;Songserm et al, 2003).…”

Section: Aetiologymentioning

confidence: 99%

Malabsorption syndrome in broilers

Rebel¹,

Balk²,

Post³

et al. 2006

World's Poultry Science Journal

View full text Add to dashboard Cite

show abstract

“…Tissue samples were collected from SPF Small White Beltsville turkeys inoculated at 2 days of age with 1 of 4 different strains of TRV as described by Spackman et al 44 Briefly, 4 TRV isolates were evaluated: NC/85, TX/ 98, 39 50 ]/bird) by the intratracheal and oral routes (0.1 ml each route). Sham inoculated control birds were inoculated with sterile 50% DMEM/50% F12 cell culture medium.…”

Section: Samplesmentioning

confidence: 99%

“…Diseases associated with avian origin reoviruses include viral arthritis/infectious tenosynovitis, malabsorption syndrome, stunting-runting syndrome, and various disorders characterized by pericarditis/myocarditis, chronic respiratory syndrome, nephritis, and multifocal necrotic hepatitis. 1,3,4,[8][9][10][11]21,25,31,38,47,50 Avian reoviruses have also been associated with immunosuppression 24,40 and atrophy of the bursa of Fabricius with characteristic lymphoid depletion and proliferation of connective tissue. 23,24,27,29,36,38,48 Studies in turkeys involving experimental reovirus infection have produced viral arthritis 2,19,30 and poult enteritis, 7,9,20,26,35,42 although descriptions of microscopic lesions caused by turkey-origin reoviruses (TRVs) are limited.…”

mentioning

confidence: 99%

Pathology and Virus Tissue Distribution of Turkey Origin Reoviruses in Experimentally Infected Turkey Poults

2007

View full text Add to dashboard Cite

Abstract. The pathogenesis of 4 isolates of turkey-origin reovirus (NC/SEP-R44/03, NC/98, TX/98, and NC/85) and 1 chicken-origin reovirus (1733) was examined by infecting specific pathogen free (SPF) poults. These turkey-origin reovirus (TRV) isolates were collected from turkey flocks experiencing poult enteritis and are genetically distinct from previously reported avian reoviruses. Microscopic examination of the tissues collected from the TRV-infected poults revealed different degrees of bursal atrophy characterized by lymphoid depletion and increased fibroplasia between the bursal follicles. To understand the relationship between virus spread and replication, and the induction of lesions, immunohistochemical staining (IHC) for viral antigen, in situ hybridization (ISH) for the detection of viral RNA, and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay for the detection of apoptosis in affected tissues was performed. Both IHC and ISH revealed viral antigen and RNA in the surface epithelial cells of the bursa, in macrophages in the interstitium of the bursa and, to lesser degree, in splenic red pulp macrophages and intestinal epithelial cells. Increased apoptosis of bursal lymphocytes and macrophages was observed at 2 and 5 days postinoculation. No lesions were found in tissues from poults inoculated with the virulent chicken-origin strain, however viral antigen was detected in the bursa and the intestine. Although all TRVs studied displayed similar tissue tropism, there were substantial differences in the severity of the lesions produced. Poults inoculated with NC/SEP-R44/03 or NC/98 had moderate to severe bursal atrophy, whereas poults inoculated with TX/ 98 or NC/85 presented a mild to moderate bursal lymphoid depletion. The lymphoid depletion observed in the bursa appears to be the effect of an indirectly induced apoptosis and would most likely result in immune dysfunction in poults infected with TRV.

show abstract

Virology: Isolation of a new serotype of avian reovirus associated with malabsorption syndrome in chickens

Cited by 20 publications

References 6 publications

Factors Affecting Intestinal Health in Poultry

Factors Affecting Intestinal Health in Poultry

Malabsorption syndrome in broilers

Pathology and Virus Tissue Distribution of Turkey Origin Reoviruses in Experimentally Infected Turkey Poults

Contact Info

Product

Resources

About