Virological Findings During the Smallpox Outbreak in Stockholm in 1963

Espmark, Åke; Biberfeld, Gunnel; Fagræus, Astrid; Johnsson, Torsten; Jönsson, Jakob; B, Magnusson

doi:10.1111/j.0954-6820.1966.tb05075.x

Cited by 4 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Culture assays for isolation of virus from tissue aspiration around the lesion were made in a few cases (17). They were positive in five patients whose rise of titre was less than fourfold and in seven with more than fourfold rise.…”

Section: Serovirclogical Results Correlated To Certain Cornklicationsmentioning

confidence: 99%

Postvaccinal Reactions and Complications

Bengtsson¹,

Hansson²,

Nyström³

1966

Journal of Internal Medicine

View full text Add to dashboard Cite

Section: Serovirclogical Results Correlated To Certain Cornklicationsmentioning

confidence: 99%

Postvaccinal Reactions and Complications

Bengtsson¹,

Hansson²,

Nyström³

1966

Journal of Internal Medicine

View full text Add to dashboard Cite

Smallpox—eradicated, but a growing terror threat

Tegnell

Wahrén

Elgh

2002

Clinical Microbiology and Infection

View full text Add to dashboard Cite

Smallpox is a disease that followed humanity for thousands of years up until 30 years ago. It was possible to eradicate, because an effective live vaccine from crossreacting vaccinia could be developed. Twenty years have passed since vaccinations stopped and very few people are protected against the disease today. Variola today has become an object of discussion due to the possibility that it can be used as a bioweapon. Due to the number of complications that can be expected a general vaccination is probably not possible. Research is ongoing to develop new vaccines. Many countries are improving their capabilities to respond to a renewed threat of a smallpox epidemic.

show abstract

On the Biochemical Nature of the ‘Sm’ Nucleoplasmic Antigen

Jönsson¹,

Schilling²,

R³

1981

Scand J Immunol

View full text Add to dashboard Cite

The nucleoplasmic autoantigens RNP and Sm are of particular interest because of their associations with certain symptoms of mixed connective tissue disease and systemic lupus erythematosus. The RNP is generally thought to be a ribonucleoprotein and there is evidence that its RNA may be single-stranded. Experiments presented in this report are in support of the concept that the Sm-antigen may also be an RNA protein. Purified Sm-anti-Sm precipitates were shown to have high RNA contents and treatment of Sm-antigen with RNAase in a hypotonic medium strongly reduced in antigenicity. The latter effect indicates that the Sm-antigen may in contrast to the RNP contain double-stranded RNA, a possibility also suggested by the finding that the Sm-antigen was soluble in 2 M LiCl. The Sm-antigen was found further to differ from RNP in being selectively absorbed in BD-Sephadex, while RNP remained active in the supernatant. Cytochemical studies involving stimulation and inhibition experiments with lectins and RNA polymerase inhibitors showed that the Sm-antigen was, in distinction to RNP, sensitive to rifampicin but not to alpha-amanitine. This suggests that the RNAs of the nucleoplasmic antigens may be synthesized by different RNA polymerases.

show abstract

Virological Findings During the Smallpox Outbreak in Stockholm in 1963

Cited by 4 publications

References 12 publications

Postvaccinal Reactions and Complications

Postvaccinal Reactions and Complications

Smallpox—eradicated, but a growing terror threat

On the Biochemical Nature of the ‘Sm’ Nucleoplasmic Antigen

Contact Info

Product

Resources

About