1984
DOI: 10.1016/0090-1229(84)90029-1
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Virologic, immunologic, and clinical observations on a patient during the incubation, acute, and convalescent phases of infectious mononucleosis

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Cited by 82 publications
(30 citation statements)
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“…As the symptoms of infectious mononucleosis become apparent 4 to 8 weeks after exposure to EBV, viral dissemination and transmission between compartments has likely already occurred (19,27). Therefore, it is quite striking that in 10 of 13 subjects, unique strains were detected in the oral cavity that were not detected in the blood, and the other three subjects (MO11, MO13, and MO14) contained unique strains in the blood that were not detected in the oral cavity.…”
Section: Discussionmentioning
confidence: 96%
“…As the symptoms of infectious mononucleosis become apparent 4 to 8 weeks after exposure to EBV, viral dissemination and transmission between compartments has likely already occurred (19,27). Therefore, it is quite striking that in 10 of 13 subjects, unique strains were detected in the oral cavity that were not detected in the blood, and the other three subjects (MO11, MO13, and MO14) contained unique strains in the blood that were not detected in the oral cavity.…”
Section: Discussionmentioning
confidence: 96%
“…IFN-y has been shown to be elevated in the serum of a patient following primary infection; however, it was only detectable during the incubation period and not when symptoms of acute IM developed (65). This suggests that the TH1 response may be important in controlling the early infection, but is normally downregulated, probably by the TH2 response, resulting in persistent humoral immunity, as is normally observed.…”
Section: Hypothesismentioning
confidence: 87%
“…No responses were detected at weeks 2 and 4 (data not shown). The incubation period for EBV has been reported to be 38 days for one individual (56), which suggests that vaccinee 14 became infected within a few weeks of the first immunization. This vaccinee complained of a severe sore throat and fatigue, which lasted about 2 to 3 weeks and began at about week 7.…”
Section: Resultsmentioning
confidence: 99%