Virologic and Pathogenetic Aspects of Cytomegalovirus Infection

Grundy, Jane E.

doi:10.1093/clinids/12.supplement_7.s711

Cited by 105 publications

(67 citation statements)

References 53 publications

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“…In addition to the direct harmful effects of CMV, many indirect effects have been recognized in the host cell [9]. Replication of CMV causes tissue injury.…”

Section: Pathogenesis and Immunological Basismentioning

confidence: 99%

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Cytomegalovirus infection in non-immunosuppressed critically ill patients

Jain

Duggal

Chugh

2011

J Infect Dev Ctries

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Cytomegalovirus (CMV) is an important and common cause of mortality and morbidity in immunocompromised patients such as those with HIV/AIDS, transplant recipients on immunosuppressive therapy, and malignant hematological disease. After primary infection with CMV the virus becomes latent in multiple organs and can later be reactivated during severe dysregulation of the immune system. A large population carry dormant virus and are thus at risk for reactivation. However, reactivation of CMV has been reported in "non-immunosuppressed patients" such as severe trauma, sepsis, shock, burns, cirrhosis and other critically ill patients lying in the intensive care units. Therefore, the intensivists are increasingly facing a dilemma of identifying such patients to treat and there is a debate if there is a scientific justification for prophylaxis in such immunocompetent patients.

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“…In addition to the direct harmful effects of CMV, many indirect effects have been recognized in the host cell [9]. Replication of CMV causes tissue injury.…”

Section: Pathogenesis and Immunological Basismentioning

confidence: 99%

“…The seroprevalence of CMV varies in different geographical areas and it ranges from 30-100% [1,9]. CMV infection is usually asymptomatic in immunocompetent persons.…”

Section: Epidemiologymentioning

confidence: 99%

Cytomegalovirus infection in non-immunosuppressed critically ill patients

Jain

Duggal

Chugh

2011

J Infect Dev Ctries

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“…The criteria for ascribing a pathogenic role for CMV at a particular body site has been discussed elsewhere (9,28). The major sites of CMV pathogenicity in immunecompromised patients are summarized in Table 1.…”

Section: Pathogenicity Of CMV At Different Body Sitesmentioning

confidence: 99%

“…for example, CMV hepatitis is particularly common in liver transplant recipients (33). The virus is also lhoughl to provoke graft rejection (9). and has been implicated as playing a pathogenic role in a variety of syndromes in transplant recipients which alTect the transplanted organ ( 1 0), such as graft atherosclerosis in heart and heart-lung recipients (34.35).…”

Section: Pathogenicity Of CMV At Different Body Sitesmentioning

confidence: 99%

“…a hypothesis was constructed for the pathogenesis of CMV pneumonitis (32). This hypothesis is discussed in detail elsewhere (9,32). but the major tenet is that CMV pneumonitis in allogeneic transplant recipients is an immunopathological condition, associated with aT cell response induced by CMV replication in the lung.…”

Section: Pathogenicity Of CMV In the Lungs Of Immunocompromised Patientsmentioning

confidence: 99%

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Cytomegalovirus Pathogenesis in Transplantation

Grundy¹

1993

Canadian Journal of Infectious Diseases and Medical Microbiolog

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JE GRUNDY. Cytomegalovirus pathogenesis in transplantation. Can J Infect Dis 1993;4(Suppl C):11C-17C. Cytomegalovirus (CMV) infection is an important cause of morbidity and mortality in the immunocompromised ; however. even within this group of patients, infection with CMV is not synonymous with disease. A number of factors affect the pathogenicity of U1e virus. An understanding of the mechanisms by which CMV causes disease at different sites in lhe body, and of how U1at might vary with different patient groups. is essential to the design of stategies for the prevention and treatment of disease. This review discusses the factors which affect the occurrence and type of CMV disease in different patient populations, and considers some of the underlying mechanisms which might contribute to pathology.

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Molecular epidemiology of cytomegalovirus infection in kindergarten children

Shen

Chang

et al. 1996

J. Med. Virol.

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This study was conducted to determine the source of cytomegalovirus (CMV) excretion in children who had persistent viruria. A total of 287 children, ages 3-5 years, enrolled in two kindergartens were followed for 9 months, and 28.8% of 139 CMV-infected children were found to have shed virus persistently in urine for > or = 3 months. A polymerase chain reaction (PCR)-based method provided direct evidence to demonstrate differences in CMV strains shed by 32 persistent shedders selected at random. The glycoprotein B (gB) nucleotide regions of CMV were amplified and analyzed by restriction enzyme digestion. The CMV strains shed by most of these children showed different restriction profiles compared with strains from their playmates. It is considered that persistent reactivation of endogenous CMV is the most plausible explanation.

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Virologic and Pathogenetic Aspects of Cytomegalovirus Infection

Cited by 105 publications

References 53 publications

Cytomegalovirus infection in non-immunosuppressed critically ill patients

Cytomegalovirus infection in non-immunosuppressed critically ill patients

Cytomegalovirus Pathogenesis in Transplantation

Molecular epidemiology of cytomegalovirus infection in kindergarten children

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