Virion disruption by ozone-mediated reactive oxygen species

Murray, Byron K.; Ohmine, Seiga; Tomer, David P.; Jensen, Kendal; Johnson, F. Brent; Kirsi, Jorma J.; Robison, Richard A.; O’Neill, Kim L.

doi:10.1016/j.jviromet.2008.06.004

Cited by 86 publications

(74 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ozone can inactivate viruses via direct oxidation of its components [25]. However, the viricidal activity in vivo becomes uncertain when viruses are in biological fluids or, even worse, when they are intracellular (pneumocytes, hepatocytes, epithelia, CD4 + lymphocytes, monocytes, glial and neuronal cells) because the cell's potent antioxidant system protects viral integrity [15].…”

Section: Potential Therapeutic Actions Of Ozone In Viral Diseasesmentioning

confidence: 99%

Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19

2020

View full text Add to dashboard Cite

1) Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease in China at the end of 2019 has caused a large global outbreak. Systemic ozone therapy (OT) could be potentially useful in the clinical management of several complications secondary to SARS-CoV-2. The rationale and mechanism of action has already been proven clinically in other viral infections and has been shown in research studies to be highly effective at decreasing organ damage mediated by inflammation and oxidative stress. This review summarizes the OT studies that illustrate the possible cytoprotective mechanism of action of ozone and its physiological by-products in target organs affected by SARS-CoV-2. (2) Methods: This review encompasses a total of 74 peer-reviewed original articles. It is mainly focused on ozone as a modulator of the NF-κB/Nrf2 pathways and IL-6/IL-1β expression. (3) Results: In experimental models and the few existent clinical studies, homeostasis of the free radical and antioxidant balance by OT was associated with a modulation of NF-κB/Nrf2 balance and IL-6 and IL-1β expression. These molecular mechanisms support the cytoprotective effects of OT against tissue damage present in many inflammatory diseases, including viral infections. (4) Conclusions: The potential cytoprotective role of OT in the management of organ damage induced by COVID-19 merits further research. Controlled clinical trials are needed.

show abstract

Section: Potential Therapeutic Actions Of Ozone In Viral Diseasesmentioning

confidence: 99%

Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19

2020

View full text Add to dashboard Cite

show abstract

“…It is well documented in the scientific literature that ozone-oxygen mixtures inactivate microorganisms including bacteria, fungi and viruses. 23,24 A recent study suggests that ozone inactivation of viruses occurs primarily by peroxidation of both lipid and protein. 24 Enveloped viruses in a thin liquid layer showed extreme sensitivity to ozone using concentrations ranging from 800 ppmv to 1500 ppmv.…”

Section: Discussionmentioning

confidence: 99%

“…23,24 A recent study suggests that ozone inactivation of viruses occurs primarily by peroxidation of both lipid and protein. 24 Enveloped viruses in a thin liquid layer showed extreme sensitivity to ozone using concentrations ranging from 800 ppmv to 1500 ppmv. 24 The Biozone scientific COP only allows the production of 0.04 ppmv of ozone.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cold oxygen plasma technology efficiency against different airborne respiratory viruses

Terrier

Essere

Yver

et al. 2009

Journal of Clinical Virology

View full text Add to dashboard Cite

“…would be expected to deactivate virions significantly [38], but the extent this occurs at ozone levels of aircraft lacking catalytic units is unknown. One must also weigh ozone causing a possible increase in host susceptibility and worse course of disease [39], another unknown.…”

Section: Aircraft Data Interpretationmentioning

confidence: 99%

Aerosol influenza transmission risk contours: A study of humid tropics versus winter temperate zone

Hanley¹,

Borup

2010

Virol J

View full text Add to dashboard Cite

BackgroundIn recent years, much attention has been given to the spread of influenza around the world. With the continuing human outbreak of H5N1 beginning in 2003 and the H1N1 pandemic in 2009, focus on influenza and other respiratory viruses has been increased. It has been accepted for decades that international travel via jet aircraft is a major vector for global spread of influenza, and epidemiological differences between tropical and temperate regions observed. Thus we wanted to study how indoor environmental conditions (enclosed locations) in the tropics and winter temperate zones contribute to the aerosol spread of influenza by travelers. To this end, a survey consisting of 632 readings of temperature (T) versus relative humidity (RH) in 389 different enclosed locations air travelers are likely to visit in 8 tropical nations were compared to 102 such readings in 2 Australian cities, including ground transport, hotels, shops, offices and other publicly accessible locations, along with 586 time course readings from aircraft.ResultsAn influenza transmission risk contour map was developed for T versus RH. Empirical equations were created for estimating: 1. risk relative to temperature and RH, and 2. time parameterized influenza transmission risk. Using the transmission risk contours and equations, transmission risk for each country's locations was compared with influenza reports from the countries. Higher risk enclosed locations in the tropics included new automobile transport, luxury buses, luxury hotels, and bank branches. Most temperate locations were high risk.ConclusionEnvironmental control is recommended for public health mitigation focused on higher risk enclosed locations. Public health can make use of the methods developed to track potential vulnerability to aerosol influenza. The methods presented can also be used in influenza modeling. Accounting for differential aerosol transmission using T and RH can potentially explain anomalies of influenza epidemiology in addition to seasonality in temperate climates.

show abstract

Virion disruption by ozone-mediated reactive oxygen species

Cited by 86 publications

References 20 publications

Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19

Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19

Cold oxygen plasma technology efficiency against different airborne respiratory viruses

Aerosol influenza transmission risk contours: A study of humid tropics versus winter temperate zone

Contact Info

Product

Resources

About