Virilizing Sclerosing-Stromal Tumor of the Ovary in a Young Woman With McCune Albright Syndrome: Clinical, Pathological, and Immunohistochemical Studies

Boussaid, K.; Meduri, Géri; Maïza, Jean-Christophe; Gennero, Isabelle; Escourrou, Ghislaine; Bros, Arnaud; Leguevaque, Pierre; Bennet, A.; Caron, Philippe

doi:10.1210/jc.2012-3551

Cited by 18 publications

(13 citation statements)

References 23 publications

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“…To date, 9 cases of virilising SST of the ovary have been described in the literature and three of the reported virilising SST were diagnosed during pregnancy [Table 2]. A virilising SST of the ovary in a young woman with Mc Cune Albright Syndrome was reported in 2013 by Bousssaid K et al 17. In this case, neither hormonal activity nor virilisation was observed.…”

Section: Discussionmentioning

confidence: 88%

Sclerosing stromal tumour of the ovary: A case report and the review of literature

Özdemir¹,

Sarı²,

Sen³

et al. 2014

Niger Med J

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Sclerosing stromal tumours are rare benign ovarian neoplasms of the sex cord stromal that occur predominantly in the second and third decades of life. To date, 208 cases have been recorded in the literature. Most patients have menstrual irregularities and pelvic pain. Infertility and virilisation have also been described. In this article, histopathological features and differential diagnosis of the benign sclerosing stromal tumour were described together with the literature data. It is imperative to consider the differential diagnosis of a sclerozing stromal tumour of the ovary in a young woman with an ovarian tumour. A combination of morphological, immunohistochemical, radiological and clinical findings is needed in differentiating the tumour from thecoma, fibroma/fibrosarcoma, lipoid tumours and Krukenberg tumour.

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Section: Discussionmentioning

confidence: 88%

Sclerosing stromal tumour of the ovary: A case report and the review of literature

Özdemir¹,

Sarı²,

Sen³

et al. 2014

Niger Med J

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show abstract

“…A precocious puberty in childhood has also been reported. A virilizing SST of the ovary in a young woman with Mc Cune Albright Syndrome was reported in 2012 by Bousssaid K et al, [14] and a woman with irregular menstruation was reported by Khanna M et al, [15]. To date, eight cases of virilizing SSTs have been described in the literature and two tumours were diagnosed after clomiphene treatment for infertility in patients whose ovaries had been laparoscopically normal before [16].…”

Section: Immunohistochemical Findingsmentioning

confidence: 96%

Sclerosing Stromal Tumour in Young Women: Clinicopathologic and Immunohistochemical Spectrum

Kaygusuz

Cesur²,

Çetiner³

et al. 2013

JCDR

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Aim: Sclerosing stromal tumor is a benign tumor of ovary. We aimed to review the clinical findings and immunohistochemical results of SSTs through the 7 diagnosed cases in our hospital. Material and Methods:As immunohistochemical, blocks were applied with estrogen receptor , progesterone receptor, inhibin, calretinin, melan-A, CD10, smooth muscle actin, desmine, vimentin, CD34, S-100, C-kit, cytokeratin , cytokeratin7.Results: Macroscopically, while 5 tumors had solid appearance, 2 tumors were composed of solid and cystic areas. All the tumors were in shape of ovarian masses with good limits. Microscopically, two types of cells were observed as fusiform fibroblast-like cells and theca-like cells with vacuolised cytoplasm. Immunohistochemical results: vimentin, smooth muscle actin, desmine, progesterone receptor, calretinin, inhibin were positive in all the cases; S-100, cytokeratin, cytokeratin7, estrogen receptor were negative in all the cases; CD-10 was positive in 2 cases; C-kit was positive in 5 cases; melan-A was positive in 4 cases. Conclusions:The significance of these tumors is that it is necessary to distinguish the histopathology in the frozen section in order to protect the other adnexa because of the characteristics to be observed at early ages (2 nd and 3 rd decades).Our findings support the conclusion that sclerosing stromal tumors are benign-character tumors that stem from over stroma and are hormonally active tumors because of the detected clinical and immunohistochemical results, although no hormonal effect that could be supported with laboratory tests was observed.

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“…To date, a total of 208 cases of SST have been reported in the literature [17]. The associations with Meigs syndrome and McCune-Albright syndrome have been reported previously [22][23][24].…”

Section: Discussionmentioning

confidence: 99%

“…You can discuss this article with its authors and with other AAGL members at http://www.AAGL.org/jmig-22-5-JMIG-D- [15][16][17][18][19][20][21][22][23][24] Use your Smartphone to scan this QR code and connect to the discussion forum for this article now* * Download a free QR Code scanner by searching for ''QR scanner'' in your smartphone's app store or app marketplace.…”

Section: Discussmentioning

confidence: 99%

Laparoscopic Treatment of Sclerosing Stromal Tumor of the Ovary in a Woman With Gorlin-Goltz Syndrome: A Case Report and Review of the Literature

Grechi

Clemente

Tozzi

et al. 2015

Journal of Minimally Invasive Gynecology

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Virilizing Sclerosing-Stromal Tumor of the Ovary in a Young Woman With McCune Albright Syndrome: Clinical, Pathological, and Immunohistochemical Studies

Abstract: This observation extends the clinical spectrum of ovarian pathology of women with MAS. However, the mechanisms causing this ovarian tumor remain unclear, even if the gsp oncogene has been implicated in the pathogenesis of some gonadal tumors.

Cited by 18 publications

References 23 publications

Sclerosing stromal tumour of the ovary: A case report and the review of literature

Sclerosing stromal tumour of the ovary: A case report and the review of literature

Sclerosing Stromal Tumour in Young Women: Clinicopathologic and Immunohistochemical Spectrum

Laparoscopic Treatment of Sclerosing Stromal Tumor of the Ovary in a Woman With Gorlin-Goltz Syndrome: A Case Report and Review of the Literature

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