Virilizing mature ovarian cystic teratomas

López-Beltrán, Antonio; Calañas, Alfonso S.; Jimena, Pilar; Escudero, Alberto L.; Campello, Telma R.; Muñóz-Torres, Manuel; Escobar-Jiménez, Fernándo; Carvia, Rafael E.; Nogales, F.

doi:10.1007/s004280050081

Cited by 17 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6e8 Most of the virilizing dermoid cysts were identified in postmenopausal women. 5 The youngest patient reported with evidence of virilization associated with a mature teratoma was 25 years old. 9 Therefore, this was an exceedingly rare event to have been identified in an early adolescent with a virilizing type of mature dermoid cyst.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, there is evidence that virilization can occur after the induction of tissue and not necessarily at a critical time in pubertal development. 5 It is unusual for a mature teratoma to exhibit cells producing active testosterone, and even more rare in the adolescent age group. The disruption of the patient's menstrual cycle for three months prior to her presentation may be explained by rapid growth of the tumor, but a true explanation for this occurrence would only be speculative.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Virilizing Ovarian Dermoid Cyst with Leydig Cells

Hoffman

Strickland

Yin

2009

Journal of Pediatric and Adolescent Gynecology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Virilizing Ovarian Dermoid Cyst with Leydig Cells

Hoffman

Strickland

Yin

2009

Journal of Pediatric and Adolescent Gynecology

View full text Add to dashboard Cite

“…Hyper insulin- emia reinforces testosterone action via insulin effects in the pituitary gland, liver, and ovary (Diamanti-Kandarakis and Papavassiliou 2006). Obesity or diabetes has been previously reported in cases of virilism with MCT (Aiman et al 1977, Lopez-Beltran et al 1997, Rotenberg et al 2009). However, the long-term evaluation of diabetes and insulin resistance in this case could not be performed because of the patient's circumstances.…”

Section: Adrenocorticotropic Hormone Loading Testmentioning

confidence: 91%

Virilism and Ectopic Expression of HSD17B5 in Mature Cystic Teratoma

Kawaguchi

Mizuno

Horikawa

et al. 2017

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Mature cystic teratoma (MCT) is rarely involved in the overproduction of steroid hormones in contrast to sex cord stromal tumors. A 31-year-old woman visited our hospital with hirsutism, hoarseness, and hair loss from the scalp. Serum testosterone and free-testosterone levels were 7.3 ng/ml and 2.3 pg/ml, respectively, which were markedly in excess of the age adjusted female standard levels. Basal blood levels of steroid hormones and serum levels of 17-hydroxyprogesterone at 1 h after intravenous injection of adrenocorticotropic hormone demonstrated that 21-hydroxylase deficiency was not the underlying cause of her virilization. A subsequent chromosomal test with G-banding revealed a karyotype of 46XX. Magnetic resonance imaging revealed a mass in the left ovary, which was subsequently diagnosed as MCT. Detailed pathological analysis of the tumor indicated that it was comprised of skin components, sweat glands, with hair and fat texture, glandular epithelium and fibrous connective tissue, consistent with the characteristic composition of MCT. Immunohistochemical analysis demonstrated marked immunoreactivity of 17beta-hydroxysteroid dehydrogenase (HSD17B5), an enzyme that can convert androstenedione to testosterone. Following surgical removal of the tumor, testosterone and free testosterone levels were markedly decreased (0.3 ng/ml and 0.4 pg/ml, respectively) and other symptoms abated. In conclusion, this is the first report of an ovarian MCT associated with clinical virilization caused by the ectopic production of testosterone possibly because of an overexpression of intratumoral HSD17B5.

show abstract

“…6 Emoto et al 6 reported on the presence of blood flow in 4 cases with malignant squamous transformation, all showing substantially lower resistive indices (<0.4) suggesting neovascularization. In addition, the coexistence of mature cystic teratomas and hilus cell tumors 7 or Sertoli-Leydig cell tumors 8 in the same ovary has been previously reported in several cases. Nevertheless, in all cases, it was found in postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

Testosterone‐Secreting Mature Ovarian Teratoma Causing Severe Virilization in an Adolescent

Rotenberg

Shahabi

Dar

2009

J of Ultrasound Medicine

View full text Add to dashboard Cite

A 15-year-old nulligravida came to our clinic with hirsutism, acne, voice changes, menometrorrhagia, clitoromegaly, and an abdominal mass. She had her menarche at 12 years of age and, since then, had had regular periods. She was never sexually active. Two years earlier, she was hospitalized for several months with seizures and a mental status change that was diagnosed as Mycoplasma encephalitis. A few months after her discharge, hirsutism and aggressive behavioral changes developed, which were attributed to her encephalitis. This was followed by development of an adult masculine voice and irregular periods. Her vocal cords were visualized and were found to be normal. The patient was referred to our clinic after she was noted to have increased abdominal girth, and a large cystic mass was palpated in the left adnexa. Case ReportSonographic and Color Doppler Characteristics yperandrogenism, associated with hirsutism in adolescent girls and premenopausal women, is a common cause of irregular menses; it affects 5% to 7% of adult women.1 The most common etiology of androgen disorders is polycystic ovary syndrome, occurring in 70% to 80% of cases. 1,2Androgen-secreting neoplasms are rare and account for less than 0.3% of patients with hirsutism.2 These neoplasms should be suspected when the onset of androgenic symptoms is rapid and sudden. We report a rare case of an adolescent girl with severe virilism and behavioral changes associated with a testosterone-secreting mature ovarian teratoma.H

show abstract

Virilizing mature ovarian cystic teratomas

Cited by 17 publications

References 12 publications

Virilizing Ovarian Dermoid Cyst with Leydig Cells

Virilizing Ovarian Dermoid Cyst with Leydig Cells

Virilism and Ectopic Expression of HSD17B5 in Mature Cystic Teratoma

Testosterone‐Secreting Mature Ovarian Teratoma Causing Severe Virilization in an Adolescent

Contact Info

Product

Resources

About