Viremia in Infection Due to Echo Virus Type 9

Yoshioka, Isao; Horstmann, Dorothy M.

doi:10.1056/nejm196002042620504

Cited by 41 publications

(4 citation statements)

References 6 publications

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“…White blood cells may play a role in ECHOvirus CNS infection. Viral replication within macrophages may be one mechanism for maintaining the viremic phase associated with ECHOvirus infection in humans [25]. The pathway of spread of ECHOvirus to the CNS is thought to be hematogenous [8], and ECHO 9 has been isolated from washed peripheral leukocytes [ 191 .…”

Section: 001mentioning

confidence: 99%

ECHOvirus 33 replication in human peripheral white blood cells

Gnann¹,

Hayes²,

Smith³

et al. 1979

Journal of Medical Virology

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ECHOvirus 33 isolated from the cerebrospinal fluid of a patient with agammaglobulinemia was shown to replicate in vitro in peripheral leukocyte suspensions from a normal antibody negative donor. Replication was demonstrated by use of sequential dilution experiments. Washed glass adherent mononuclear cell cultures from a normal antibody negative donor were also capable of supporting ECHOvirus 33 replication in vitro. Leukocyte suspensions from the infected agammaglobulinemic patient extinguished detectable infectious virus in vitro.

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Section: 001mentioning

confidence: 99%

ECHOvirus 33 replication in human peripheral white blood cells

Gnann¹,

Hayes²,

Smith³

et al. 1979

Journal of Medical Virology

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“…Most of the affected individuals remain at home (22,24) suffering from a mild influenza-like syndrome (16). Only the severe cases are recognized and hospitalized.…”

Section: Virological Studiesmentioning

confidence: 99%

AN OUTBREAK AMONG CHILDREN OF ASEPTIC MENINGITIS CAUSED BY ECHOVIRUS TYPE 9 A Clinical and Serological Study

Moshkowitz¹,

Grinfeld²,

Abrahamov³

et al. 1968

Acta Paediatrica

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There are several viral diseases, prevalent during summer and autumn among children and adults in temperate zones, which are characterized by high temperature, rash, gastrointestinal disturbances, and signs of meningeal irritation. Increasing evidence, based on improvement in laboratory technique, points to Echovirus 9 as one of the enteroviruses responsible for these diseases,The purpose of the present communication is to describe a small outbreak, caused by this virus, in which the sole clinical syndrome observed was that of meningitis. The outbreak occurred in the early summer of 1967 in Jerusalem, Israel, affecting a group of children living in a fairly limited area of a residential suburb. CASE REPORTSCase I F. Z., a 121/,-year-old male, was reportedly in good health until two days prior to admission to the hospital, when he developed irritability, headache and severe vomiting. No improvement was achieved with antibiotic and antipyretic drugs. Two weeks prior to the outbreak of these symptoms he had suffered from chickenpox and pneumonia, from which he had completely recovered.Physical examination on admissioc revealed a pa!e sick-looking child. Temperature was 37°C; pulse rate, 134 per minute; respiratory rate, 30 per minute; blood pressure, 100/65 mm Hg. There was some neck rigidity and Kernig's and Brudzinski's signs were negative. Tendon and cutaneous reflexes and plantar responses were normal. The tongue was wet and white. Systolic murmur grade I was found in the heart. There was no other abnormal findings in the physical examination. Two days later his condition became worse, fever remained high, headache was severe, and the child complained of vertigo and dizziness. Physical examination revealed a marked neck rigidity, and Kernig's and Brudzinski's signs were positive. Tendon and cutaneous reflexes were slightly diminished, and Babinski's sign was positive on both sides.Laboratory data. The urine was normal chemically and microscopically. The blood count showed: Hb, 12.7 g/ 100 ml; h e m a t o c r i t 4 0 % ; W.B.C., 11,500 per mm3 (72% neutrophils, of which 13% were bands, 25% lymphocytes, 4% monocytes). R.B.C. morphology was normal. E.S.R., 38/50. Serum glucose and electrolytes were normal. Findings in the cerebrospinal fluid (CSF) were as follows. Cells-2350 leucocytes (90 % lymphocytes) and 5 RBC, per cubic mm; sugar, 35 mg/100 ml; protein, 58 mg/100 ml; chloride, 113 mEq/l. Bacterial culture was negative. Viral culture of the CSF yielded echovirus 9.

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“…In cases of minor illness the virus can be found in both throat and faeces for four to seven days, and it has been demonstrated in the blood during the incubation period up to five days before the onset of symptois (Yoshioka and Horstmann', 1960). Studies in families suggest a minimum incubation period of five or more days.…”

Section: Pattern Of Infection With Echo 9 Virusmentioning

confidence: 99%

Viruses of Human Diseases

Stuart-Harris¹

1962

BMJ

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Viremia in Infection Due to Echo Virus Type 9

Cited by 41 publications

References 6 publications

ECHOvirus 33 replication in human peripheral white blood cells

ECHOvirus 33 replication in human peripheral white blood cells

AN OUTBREAK AMONG CHILDREN OF ASEPTIC MENINGITIS CAUSED BY ECHOVIRUS TYPE 9 A Clinical and Serological Study

Viruses of Human Diseases

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