Virchow's Node Revisited

Shetty, Meenakshi

doi:10.1001/archotol.1988.01860170108030

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…The prevalence of VM among patients with other abdominal and thoracic malignancies has previously been estimated up to 2.8%. Among those patients who presented with VM involvement, the highest frequency was in patients with lung cancer followed by cancer of the pancreas, esophagus, kidney, ovary, testicle, stomach, prostate, uterus, and rectum [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Heterogeneity of Small Intestinal Neuroendocrine Tumors Metastasis: Biologic Patterns of a Series with Virchow’s Node Involvement

Wedin

Tsoli

Wallin

et al. 2022

Cancers

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Small intestinal neuroendocrine tumors (SI-NETs) may rarely metastasize to the left supraclavicular lymph nodes, also known as Virchow’s node metastasis (VM). Data on prevalence, prognostic significance, and clinical course of disease for SI-NET patients with VM is limited. In this retrospective analysis of 230 SI-NET patients treated at two tertiary referral centers, we found nine patients with VM (prevalence 3.9%). Among those, there were 5 females and median age at SI-NET and VM diagnosis was 61 and 65 years, respectively. Two patients had G1 tumors and five G2, while two tumors were of unspecified grade (median Ki67: 7%, range 2–15%). Four patients presented with synchronous VM, whereas five developed metachronous VM after a median of twenty-four months (range: 4.8–117.6 months). Hepatic metastases were present in seven patients, extrahepatic metastases (EM) in eight (six para-aortic distant lymph node metastases, one lung and one pancreatic metastasis), whereas peritoneal carcinomatosis (PC) in two patients. We used a control group of 18 age- and sex-matched SI-NET patients from the same cohort with stage IV disease but no extra-abdominal metastases. There was no difference in best-recorded response to first line treatment according to RECIST 1.1 as well as progression-free survival (PFS) between patients with VM and those in the control group (Chi-square test p = 0.516; PFS 71.7 vs. 106.9 months [95% CI 38.1–175.8]; log-rank p = 0.855). In addition, median overall survival (OS) of SI-NET patients with VM did not differ from those in the control group (138.6 [95% CI 17.2–260] vs. 109.9 [95% CI 91.7–128] months; log-rank p = 0.533). In conclusion, VM, although relatively rare in patients with SI-NETs, is more often encountered in patients with G2 tumors and established distant para-aortic lymph node metastases. The presence of VM in SI-NET patients does not seem to impact patients’ survival outcomes and treatment responses, when compared to age- and sex-matched SI-NET patients with stage IV disease confined in the abdomen.

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Section: Discussionmentioning

confidence: 99%

Heterogeneity of Small Intestinal Neuroendocrine Tumors Metastasis: Biologic Patterns of a Series with Virchow’s Node Involvement

Wedin

Tsoli

Wallin

et al. 2022

Cancers

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“…3,10 The prevalence of Virchow's lymph node metastasis among patients with abdominal and thoracic malignancies has previously been estimated to be up to 2.8%. 30 Among those who present with Virchow's lymph node involvement, the highest frequency was found in patients with primary lung cancer, followed by cancer of the pancreas, oesophagus, kidney, ovary, testicle, stomach, prostate, uterus, and rectum. 30 In the present study, Si-NET and Pan-NET patients harboured Virchow's lymph node in 10% and 2% respectively, again indicating the differences in metastatic pattern between the two NET types.…”

Section: Discussionmentioning

confidence: 99%

“…30 Among those who present with Virchow's lymph node involvement, the highest frequency was found in patients with primary lung cancer, followed by cancer of the pancreas, oesophagus, kidney, ovary, testicle, stomach, prostate, uterus, and rectum. 30 In the present study, Si-NET and Pan-NET patients harboured Virchow's lymph node in 10% and 2% respectively, again indicating the differences in metastatic pattern between the two NET types. In a previous publication of nine Si-NET patients with Virchow's lymph node metastasis, the presence of this metastasis did not influence the patients´survival, as compared to a control group of ageand sex-matched Si-NET patients with stage IV disease.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of Virchow's lymph node metastasis among patients with abdominal and thoracic malignancies has previously been estimated to be up to 2.8% 30 . Among those who present with Virchow's lymph node involvement, the highest frequency was found in patients with primary lung cancer, followed by cancer of the pancreas, oesophagus, kidney, ovary, testicle, stomach, prostate, uterus, and rectum 30 .…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of metastases outside the liver and abdominal lymph nodes on ⁶⁸Ga‐DOTATOC‐PET/CT in patients with small intestinal and pancreatic neuroendocrine tumours

Wedin,

Janson,

Wallin

et al. 2024

J Neuroendocrinology

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Metastases outside the liver and abdominal/retroperitoneal lymph nodes are nowadays detected frequently in patients with neuroendocrine tumours (NETs), owing to the high sensitivity of positron emission tomography (PET) with Gallium‐68‐DOTA‐somatostatin analogues (68Ga‐SSA) and concomitant diagnostic computed tomography (CT). Our aim was to determine the prevalence of extra‐abdominal metastases on 68Ga‐DOTATOC‐PET/CT in a cohort of patients with small intestinal (Si‐NET) and pancreatic NET (Pan‐NET), as well as that of pancreatic metastasis in patients with Si‐NET. Among 2090 patients examined by 68Ga‐DOTATOC‐PET/CT at two tertiary referral centres, a total of 1177 patients with a history of Si‐ or Pan‐NET, were identified. The most recent 68Ga‐DOTATOC‐PET/CT report for each patient was reviewed, and the location and number of metastases of interest were recorded. Lesions outside the liver and abdominal nodes were found in 26% of patients (n = 310/1177), of whom 21.5% (255/1177) were diagnosed with Si‐NET and 4.5% (55/1177) Pan‐NET. Bone metastases were found in 18.4% (215/1177), metastases to Virchow's lymph node in 7.1% (83/1177), and lung/pleura in 4.8% (56/1177). In the subset of 255 Si‐NET patients, 5.4% (41/255) manifested lesions in the pancreas, 1.5% in the breast (18/255), 1.3% in the heart (15/255) and 1% in the orbita (12/255). In Si‐NET patients, the Ki‐67 proliferation index was higher in those with ≥2 metastatic sites of interest, than with 1 metastatic site, (p <0.001). Overall, extra‐abdominal or pancreatic metastases were more often found in patients with Si‐NET (34%) than in those with Pan‐NET (13%) (p <0.001). Bone metastases were 2.6 times more frequent in patients with Si‐NET compared to Pan‐NET patients (p <0.001). Lesions to the breast and orbita were encountered in almost only Si‐NET patients. In conclusion, lesions outside the liver and abdominal nodes were detected in as many as 26% of the patients, with different prevalence and metastatic patterns in patients with Si‐NET compared to Pan‐NET. The impact of such metastases on overall survival and clinical decision‐making needs further evaluation.

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Indirect Microscopic Laryngoscopy

Golz¹,

Zohar²,

Avraham³

et al. 1989

Archives of Otolaryngology - Head and Neck Surgery

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Virchow's Node Revisited

Cited by 3 publications

References 11 publications

Heterogeneity of Small Intestinal Neuroendocrine Tumors Metastasis: Biologic Patterns of a Series with Virchow’s Node Involvement

Heterogeneity of Small Intestinal Neuroendocrine Tumors Metastasis: Biologic Patterns of a Series with Virchow’s Node Involvement

Prevalence of metastases outside the liver and abdominal lymph nodes on ⁶⁸Ga‐DOTATOC‐PET/CT in patients with small intestinal and pancreatic neuroendocrine tumours

Indirect Microscopic Laryngoscopy

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Virchow's Node Revisited

Cited by 3 publications

References 11 publications

Heterogeneity of Small Intestinal Neuroendocrine Tumors Metastasis: Biologic Patterns of a Series with Virchow’s Node Involvement

Heterogeneity of Small Intestinal Neuroendocrine Tumors Metastasis: Biologic Patterns of a Series with Virchow’s Node Involvement

Prevalence of metastases outside the liver and abdominal lymph nodes on 68Ga‐DOTATOC‐PET/CT in patients with small intestinal and pancreatic neuroendocrine tumours

Indirect Microscopic Laryngoscopy

Contact Info

Product

Resources

About

Prevalence of metastases outside the liver and abdominal lymph nodes on ⁶⁸Ga‐DOTATOC‐PET/CT in patients with small intestinal and pancreatic neuroendocrine tumours