Viralization Due to Leydig Cell Tumor Diagnosis by Magnetic Resonance Imaging

Abstract

A 3-year-old boy who presented with signs of virilization had a Leydig cell tumor of the left testis that could not be detected by physical examination or by high resolution ultrasonography. His very small tumor was demonstrated by magnetic resonance imaging. The implications of adding this sensitive method of imaging to the evaluation of prepubertal virilization of presumed testicular etiology are discussed.

Saf Leydig hücresi tümörü: nadir bir olgu sunumu

“…Metastatic type LCTs are seen only in adults and often over 40 years of age patients. The malignancy risk in undescended testes was 4 to 10 times higher than general population (11). In our case, our clinical and histological findings were consistent with the literature and no malignant course or endocrine disorder was observed in 4 year follow-up.…”

Prepubertal testicular tumors: Our 10 years experience

“…[4,5,[11][12][13] Magnetic resonance imaging may detect small, functioning Leydig cell tumors that are not evident on ultrasound. [14] Testicular tumor markers are important tools in the evaluation of testicular tumors in children. Because yolk sac tumor is the only important malignant germ cell tumor in children, human chorionic gonadotropin is not a helpful marker.…”

Leydig Cell Testicular Tumour Presenting as Isosexual Precocious Pseudopuberty in a 5 Year-old Boy with No Palpable Testicular Mass

“…Testosterone-secreting Leydig cell testicular adenomas represent 1–3% of all testicular tumors. The majority of these tumors have been observed in men aged 30–60 yr, and less than 25% have been reported in prepubertal boys (6, 7). Bilateral Leydig cell tumor has been reported in only 3–10% of cases (1).…”

“…Diverse sex steroid-producing entities could cause isosexual precocity. The clinical characteristics include rapidly somatic growth spurt, pubic and axillar hair, facial acne, painful erections, penis enlargement and deep voice (7,8,9). With the exception of our case, all pediatric patients reported in the available literature presented with a palpable testicular mass on clinical examination.…”